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6 compared with 12 weeks treatment in the von Rosen splint is sufficient for Barlow and Ortolani positive hipsa comparative study of 237 neonates

Background and purpose — At our institution, new-borns with Barlow or Ortolani positive hips have been treated for 12 weeks with the von Rosen abduction splint until 2012 when the treatment length was halved. We inves-tigate whether acetabular development at 12 months of age and complications differ between hips treated with the von Rosen splint for 6 compared with 12 weeks. Patients and methods —

Adaptive, maladaptive, neutral, or absent plasticity : Hidden caveats of reaction norms

Adaptive phenotypic plasticity may improve the response of individuals when faced with new environmental conditions. Typically, empirical evidence for plasticity is based on phenotypic reaction norms obtained in reciprocal transplant experiments. In such experiments, individuals from their native environment are transplanted into a different environment, and a number of trait values, potentially i

Heterocontact-Triggered 1H to 1T′ Phase Transition in CVD-Grown Monolayer MoTe2 : Implications for Low Contact Resistance Electronic Devices

Single-layer molybdenum ditelluride (MoTe2) has attracted attention due to the smaller energy difference between the semiconducting (1H) and semimetallic (1T′) phases with respect to other two-dimensional transition metal dichalcogenides (TMDs). Understanding the phenomenon of polymorphism between these structural phases is of great fundamental and practical importance. In this paper, we report a

Protease-Responsive Hydrogel Microparticles for Intradermal Drug Delivery

Protease-responsive multi-arm polyethylene glycol-based microparticles with biscysteine peptide crosslinkers (CGPGG↓LAGGC) were obtained for intradermal drug delivery through inverse suspension photopolymerization. The average size of the spherical hydrated microparticles was ∼40 μm after crosslinking, making them attractive as a skin depot and suitable for intradermal injections, as they are read

Analyzing polysemiosis : Language, gesture, and depiction in two cultural practices with sand drawing

Human communication is by default polysemiotic: it involves the spontaneous combination of two or more semiotic systems, the most important ones being language, gesture, and depiction. We formulate an original cognitive-semiotic framework for the analysis of polysemiosis, contrasting this with more familiar systems based on the ambiguous term "multimodality."To be fully explicit, we developed a co

Numerical study on thermal performance of cold plates with leaf type channels for lithium-ion batteries

Purpose: The purpose of this study is to design a new type of cold plate to improve the thermal performance of liquid-cooled thermal management system of lithium-ion batteries. Design/methodology/approach: A cold plate with leaf type channels is proposed to enhance the cooling performance. Effects of the leaf type channel parameters (i.e. channel angle 20°, 40°, 60°, 80°; coolant mass flow rate 0.

The Spanish Habsburgs and Dynastic Rule, 1500–1700

Providing a novel research methodology for students and scholars with an interest in dynasties, at all levels, this book explores the Spanish Habsburg dynasty that ruled the Spanish monarchy between c. 1515 and 1700. Instead of focusing on the reigns of successive kings, the book focuses on the Habsburgs as a family group that was constructed in various ways: as a community of heirs, a genealogica

Can active sun exposure decrease the risk of giant cell arteritis and polymyalgia rheumatica in women?

ObjectivesTo study if active sun exposure among women affects the risk of developing GCA or PMR in a prospective cohort study with restricted latitudinal variability.MethodsWe linked the response to questions relating to sun exposure from the Melanoma Inquiry in Southern Sweden (MISS) prospective cohort study in women to the risk of developing GCA or PMR. Healthcare data were gathered from the Skå

Overcoming challenges in rare disease registry integration using the semantic web - a clinical research perspective

The growing number of disease-specific patient registries for rare diseases has highlighted the need for registry interoperability and data linkage, leading to large-scale rare disease data integration projects using Semantic Web based solutions. These technologies may be difficult to grasp for rare disease experts, leading to limited involvement by domain expertise in the data integration process

Cortical changes during the learning of sequences of simultaneous finger presses

The cortical alterations underpinning the acquisition of motor skills remain debated. In this longitudinal study in younger adults, we acquired performance and neuroimaging (7 T MRI) measures weekly over the course of 6 weeks to investigate neural changes associated with learning sequences of simultaneous finger presses executed with the non-dominant hand. Both the intervention group (n = 33), whi

Discordance in Frailty Measures in Old Community Dwelling People with Multimorbidity - A Cross-Sectional Study

PURPOSE: Assessment of frailty is a key method to identify older people in need of holistic care. However, agreement between different frailty instrument varies. Thus, groups classified as frail by different instruments are not completely overlapping. This study evaluated differences in sociodemographic factors, cognition, functional status, and quality of life between older persons with multimorb

Aging Hematopoiesis: Functional Insights and Prospects for Rejuvenation

Aging exerts profound effects on the hematopoietic system, leading to a loss of homeostatic control and reduced regenerative capacity. Clinical consequences of these changes include anemia, compromised immune function and an increased prevalence of myeloid disorders among the elderlies. A growing body of evidence suggests that defects at the stem and progenitor cell levels contribute to many of th

Sports-Related Traumatic Brain Injury

The speed and intensity of modern sports puts the athlete at risk for impacts to the head, or to the body when the impact force is transmitted to the head. Rapid head rotation caused by these impact forces may lead to a sports-related concussion (SRC), defined as a mild traumatic brain injury, typically resulting in short-lived disturbance of the central nervous system function. The diagnosis of S