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Drug Dependent Circadian Variations in AV-nodal Properties During Atrial Fibrillation

The heart rate during atrial fibrillation (AF) is highly dependent on the conduction properties of the atrioventricular (AV) node, which can be affected using β-blockers or calcium channel blockers, often chosen empirically. Thus, characterization of the AV nodal conduction properties could contribute to personalized treatment of AF. We have created a mathematical network model of the AV node wher

Identification and validation of NFIA as a novel prognostic marker in renal cell carcinoma

Prognostic tools are an essential component of the clinical management of patients with renal cell carcinoma (RCC). Although tumour stage and grade can provide important information, they fail to consider patient- and tumour-specific biology. In this study, we set out to find a novel molecular marker of RCC by using hepatocyte nuclear factor 4A (HNF4A), a transcription factor implicated in RCC pro

DomHR : Accurately Identifying Domain Boundaries in Proteins Using a Hinge Region Strategy

Motivation: The precise prediction of protein domains, which are the structural, functional and evolutionary units of proteins, has been a research focus in recent years. Although many methods have been presented for predicting protein domains and boundaries, the accuracy of predictions could be improved. Results: In this study we present a novel approach, DomHR, which is an accurate predictor of

Predicting Gram-positive bacterial protein subcellular localization based on localization motifs

The subcellular localization of proteins is closely related to their functions. In this work, we propose a novel approach based on localization motifs to improve the accuracy of predicting subcellular localization of Gram-positive bacterial proteins. Our approach performed well on a five-fold cross validation with an overall success rate of 89.5%. Besides, the overall success rate of an independen

Impact of pulp chemical composition and fiber morphology on hygroexpansion and strength properties of kraftliner

Kraftliner is the unbleached pulp used in the outermost layer of corrugated cardboard. Like other types of paper, it is produced from wood chips as a raw material. Kraftliner is known for its high tensile strength, tear resistance, compressive strength, etc., making it suitable for packaging material for heavy objects. When paper is exposed to moisture, there is usually a dimensional change within

Hand-arm vibration : Swedish carpenters' perceptions of health and safety management

Background: Workers in the construction industry are highly exposed to vibration from handheld equipment, which can have negative effects on the nerves and blood vessels in the hands. Employers in this industry often fail to comply with legislation regarding vibration exposure. Aims: To assess carpenters' perceptions of proactive health and safety (H&S) management regarding hand-arm vibration

The EU institutions' framing of the Covid crisis: from global pandemic to green recovery

This thesis aims to study how the legitimacy of the EU’s pandemic crisis response in connection to green policies, in the interinstitutional exchange, is supported or undermined by connected frames and a subordinate master frame over the course of the first six months of the unfolding pandemic. Six EU institutions’ residents, who “have a say” on economic crisis measures, were picked from the Europ

Development of a core descriptor set for Crohn's anal fistula

Aim: Crohn's anal fistula (CAF) is a complex condition, with no agreement on which patient characteristics should be routinely reported in studies. The aim of this study was to develop a core descriptor set of key patient characteristics for reporting in all CAF research. Method: Candidate descriptors were generated from published literature and stakeholder suggestions. Colorectal surgeons, gastro

"It is something that gives us hope" : Lived experience among parents to children with cerebral palsy who are non-ambulant of the phenomenon physical activity, with or without the use of a novel dynamic standing device

INTRODUCTION: Regular physical activity confers health benefits for all. Parents commonly want their children to be physically active, and want to be physically active themselves, but children with cerebral palsy (CP) who are non-ambulant face challenges, and they need support to be physically active. Dynamic standing in the novel motorized assistive device Innowalk has positive effects in childre

Arbetsterapeutiska interventioner och deras påverkan på aktivitet och delaktighet för vuxna med schizofreni - en litteraturstudie

Bakgrund: Majoriteten av personer med schizofreni upplever begränsningar relaterat till aktivitet och delaktighet i vardagliga aktiviteter. Symtombilden består till stor del av positiva och negativa symtom och en bristande sjukdomsinsikt. Det råder begränsad evidens kring hur arbetsterapeutiska interventioner påverkar aktivitet och delaktighet för personer med schizofreni. Syfte: Att kartlägga arbBackground: Most people with schizophrenia experience limitations related to activity and participation in everyday activities. The symptoms largely consist of positive and negative symptoms and a lack of disease insight. There is limited evidence on how occupational therapy interventions affect people with schizophrenia. Aim: To map occupational therapy interventions that affect activity and part

The Memory of Meanings : The Images of Jewish-Catholic Relations in Interwar Lublin in Oral Histories

This work explores narratives of Jewish-Catholic relations in interwar Lublin, as recalled by its Jewish and Catholic inhabitants by the end of their lives. Thus, it concerns both memory and intergroup relations and seeks to understand the attitudes towards the religious Other. The main body of sources for this qualitative study is a collection of oral histories from the Grodzka Gate – NN Theatre

Deformation dependence of magnetic dipole strength below 4 MeV in doubly even rare earth nuclei

We show: (1) In the presence of the pair correlation the M1 transition strength calculated in the deformed oscillator model has a dependence on the quadrupole deformation parameter δ which is considerably stronger than linear and, in fact, it varies quadratically with δ in the limit of small deformation; (2) The deformation dependence in samarium isotopes calculated using the quasiparticle random

Inscriptions from Neoklaudiopolis/Andrapa (Vezirköprü, Turkey)

Within recent years, a number of inscriptions have come to light in Vezirköprü (ancient Neapolis/Neoklaudiopolis/Andrapa) and its immediate environs. The district known as the Cumhuriyet Mahallesi immediately to the south of the present town centre has been especially rich in ancient remains, and many of these, along with spoils and inscriptions from other parts of the city, have now been brought

Coordinated carbon taxes or tightened NDCs : Distributional implications of two options for climate negotiations

Concerns about fairness among countries remain significant obstacles to a stronger global climate treaty. This paper addresses the distributional implications of two mechanisms to strengthen the Paris Agreement, the incorporation of national carbon pricing, and the tightening of nationally determined contributions (NDCs). Both are found to be viable mechanisms. They are also less extreme, and ther

Tilt-Induced Changes in RR Series Characteristics : An AV Node Simulation Study

In the ECG recordings during tilt test, changes in RR series characteristics can be observed. The purpose of the present study is to investigate to what extent these changes can be explained by changes in the atrial input and in the atrioventricular (AV) nodal characteristics induced by the autonomic nervous system (ANS). Average RR series characteristics (mean, rmssd and sample entropy) and avera

Introduction : Images in the Making

In the book’s introductory chapter long-held assumptions concerning archaeological art and images are addressed and challenged, particularly representationalism, and new ways to approach and understand them are offered. Specifically, it is argued that art and images continuously emerge in processes of making and engagement, both in the past and in the present. Hence, art and images are always in m

Parental Leave Reforms in South Korea, 1995–2021: Policy Translation and Institutional Legacies

This article aims to explore how policy translation and institutional legacies have shaped South Korean parental leave policies between 1995 and 2021. It draws on a document analysis of central political documents and interviews with a number of key policy actors in South Korea. The findings show that reforms of parental leave policies were implemented according to four major rationales: maternityThis article aims to explore how policy translation and institutional legacies have shaped South Korean parental leave policies between 1995 and 2021. It draws on a document analysis of central political documents and interviews with a number of key policy actors in South Korea. The findings show that reforms of parental leave policies were implemented according to four major rationales: maternity

Healthcare professionals' experiences and views of eHealth in pediatric care : qualitative interview study applying a theoretical framework for implementation

Objective: This study aims to investigate the perspectives and insights of health care professionals (HCPs) regarding the implementation of an eHealth intervention in pediatric health care while applying the NASSS framework to theorize and evaluate the conditions influencing the implementation of eHealth solutions.Methods: Semistructured interviews were performed with health care providers, includ