Galectin-3 is an endogenous β-galactoside-binding lectin comprising a carbohydrate recognition domain (CRD) linked to a collagen-like N-domain. Both domains are required for galectin-3 to induce cellular effects; a C-terminal fragment of galectin-3, galectin-3C, containing the CRD but lacking the N-domain, binds cell surface glycoconjugates but does not induce cellular effects since cross-linking

Maggots of the blowfly Lucilia sericata are used for the treatment of chronic wounds. As haemostatic processes play an important role in wound healing, this study focused on the effects of maggot secretions on coagulation and fibrinolysis. The results showed that maggot secretions enhance plasminogen activator-induced formation of plasmin and fibrinolysis in a dose- and time-dependent manner. By c

The current issue of Journal of Intercultural and Interdisciplinary Archaeology is mainly dedicated to the various aspects of Renenutet/Isis Thermouthis, but also snake-like deities, their iconography and associated apotropaia. This paper will explore three main topics associated with this topic within the sandstone quarry of Gebel el Silsila: 1) Graeco-Roman anguiform pictorial representations, 2

Persistent plumage colour polymorphism occurs in around 3.5% of bird species, with raptors showing a disproportionately high frequency of such polymorphisms. The genus Buteo has more polymorphic species than any other raptor genus (15 polymorphic species out of 25). These polymorphisms are interesting from an evolutionary perspective, because they are heritable and hence a good model for understan

β-1,4-Galactosyltransferase 7 (β4GalT7) is a key enzyme in the biosynthesis of glycosaminoglycan (GAG) chains. Natural and synthetic xylosides can be used to both inhibit and prime GAG synthesis by acting as inhibitors or substrates for β4GalT7. In this report, we exploit hydroxylated oxanes as deoxygenated xyloside analogs to clarify the minimum protein-ligand interactions required for galactosyl

Comprehensive transcriptome studies of cancers often rely on corresponding normal tissue samples to serve as a transcriptional reference. In this study, we performed in-depth analyses of normal kidney tissue transcriptomes from the TCGA and demonstrate that the histological variability in cellularity, inherent in the kidney architecture, lead to considerable transcriptional differences between sam

Heme oxygenase is an enzyme that degrades heme, thereby recycling iron in most organisms, including humans. Pervious density functional theory (DFT) calculations have suggested that iron(III) hydroxyheme, an intermediate generated in the first step of heme degradation by heme oxygenase, is converted to iron(III) superoxo oxophlorin in the presence of dioxygen. In this article, we have studied the

Integrin αβ heterodimer cell surface receptors mediate adhesive interactions that provide traction for cell migration. Here, we test whether the integrin, when engaged to an extracellular ligand and the cytoskeleton, adopts a specific orientation dictated by the direction of actin flow on the surface of migrating cells. We insert GFP into the rigid, ligand-binding head of the integrin, model with

Enterprise Resource Planning (ERP) system literature reports little research on the specificities of an industry analysis. Based on a theoretical model we assess ERP Value between Manufacturing and Services industries in Small and Medium Enterprises (SMEs) across the Iberian region (Portugal and Spain). The empirical test was conducted through structural equation modeling, using data from 261 firm

The Gebel el Silsila Project is a multi-disciplinary Swedish mission dedicated to the study of the archaeological remains at Ancient Egypt’s largest sandstone quarry of Gebel el Silsila, Mountain of Chain, just north of Kom Ombo in the Aswan region. This paper presents a general summary of the epigraphical and archaeo-topographical survey of the largest quarry on the east bank – Quarry 34 or the MThe Gebel el Silsila Project is a multi-disciplinary Swedish mission dedicated to the study of the archaeological remains at Ancient Egypt’s largest sandstone quarry of Gebel el Silsila, Mountain of Chain, just north of Kom Ombo in the Aswan region. This paper presents a general summary of the epigraphical and archaeo-topographical survey of the largest quarry on the east bank – Quarry 34 or the M

Swedish society is characterized by secularization, and at the same time, as a result of migration, the country has become more pluralistic. An important consequence of this is the increasing possibilities for cooperation between different religious communities, and a variety of inter-religious cooperation are currently taking place in Sweden. The aim of the article is to show how inter-religious

Structural technologies are an essential component in the design of precision therapeutics. Precision medicine entails the development of therapeutics directed toward a designated target protein, with the goal to deliver the right drug to the right patient at the right time. In the field of oncology, protein structural variants are often associated with oncogenic potential. In a previous proteogen