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Galectin-3 Targeted Therapy with a Small Molecule Inhibitor Activates Apoptosis and Enhances Both Chemosensitivity and Radiosensitivity in Papillary Thyroid Cancer

Although most patients with papillary thyroid cancer (PTC) have favorable outcomes, some have advanced PTC that is refractory to external beam radiation and systemic chemotherapy. Galectin-3 (Gal-3) is a beta-galactoside-binding protein with antiapoptotic activity that is consistently overexpressed in PTC. The purpose of this study is to determine if Gal-3 inhibition promotes apoptosis, chemosensi

Aspects of bleeding complications and hemostasis at central line insertion and mild induced hypothermia

Popular Abstract in Swedish Blodlevring är en samlingsterm för en serie reaktioner som medför att blod omvandlas från vätska till en geléliknande massa. I koagulationsprocessen samverkar de minsta cellerna i blodet, trombocyterna (blodplättarna), med ett stort antal blodproteiner. Koagulationens viktigaste uppgift är att stoppa blödningar som uppkommer vid skador på blodkärlen. Central venkateteBleeding complications range from 0.5 to 1.6% in connection with central venous catheter insertions but are more frequent in patients with bone marrow failure and severe thrombocytopenia. Although supportive evidence is scarce, prophylactic platelet transfusion is sometimes performed in these patients before catheter insertion. Furthermore, the ideal threshold platelet count and timing of transfus

Energy-Efficient Decentralized Cooperative Routing in Wireless Networks

Wireless adhoc networks transmit information from a source to a destination via multiple hops in order to save energy and, thus, increase the lifetime of battery-operated nodes. The energy savings can be especially significant in cooperative transmission schemes, where several nodes cooperate during one hop to forward the information to the next node along a route to the destination. Finding the b

The Merit of Meritocratization: Politics, Bureaucracy, and the Institutional Deterrents of Corruption

Comparative studies of corruption focus on the selection and incentives of policymakers. With few exceptions, actors who are in charge of implementing policies have been neglected. This article analyzes an original data set on the bureaucratic features and its effects on corruption in fifty-two countries. Two empirical findings challenge the conventional wisdom in literature. First, certain bureau

Interaction between two spheres placed in tandem arrangement in steady and pulsating flow

The interaction among two spheres in tandem formation are studied for a Reynolds number of 300 using both steady and pulsating inflow conditions. The purpose is to further investigate the force characteristics as well as the shedding patterns of the two spheres as the separation distance is changed from 1.5 to 12. sphere diameters. The method used for the simulations is the volume of solid (VOS) m

Highlights from PHENIX I

This contribution highlights recent results from the PHENIX Collaboration at RHIC. It covers global variables, flow and 2-particle correlations. A second contribution in this issue, by T C Awes (2008 J. Phys. G: Nucl. Part. Phys. 35 104007), covers PHENIX results on heavy quarks, leptons and photons.

The effect of elevated pressures on the laminar burning velocity of methane plus air mixtures

In spite of the large amount of research spent on the evaluation of the high pressure dependence of laminar burning velocity of methane + air flame, there still exists a large uncertainty in the data for various reasons. In order to reduce the scatter to acceptable levels, the Heat Flux Method (HFM), known as a potential method with high accuracy, has been extended to higher pressures. New measure

The 9p21.3 risk of childhood acute lymphoblastic leukaemia is explained by a rare high-impact variant in CDKN2A.

Genome-wide association studies (GWAS) have provided strong evidence for inherited predisposition to childhood acute lymphoblastic leukaemia (ALL) identifying a number of risk loci. We have previously shown common SNPs at 9p21.3 influence ALL risk. These SNP associations are generally not themselves candidates for causality, but simply act as markers for functional variants. By means of imputation

The business model of solid waste management in Sweden – A case study of two municipally-owned companies

Abstract in UndeterminedThis paper describes the business model of municipally-owned MSW (municipal solid waste) companies in Sweden. A comparative study of two of these companies shows that they combine three types of activities: public service activities that collect solid waste from households, commercial establishments, and industry; processing activities that transform this waste; and marketi

Antiproliferative effects of curcuphenol, a sesquiterpene phenol.

Curcuphenol is a sesquiterpene isolated from sponges and plants having several significant biological activities. The present study explored its effect on cell proliferation and apoptosis in Caco-2 human colon cancer cells. It was demonstrated that curcuphenol in concentrations in the range of 29-116microg/ml inhibited cell proliferation and DNA replication and induced cell death in a dose-depende

Lund University Supports Publishing in OA Journals

In the 2009 budget Lund university has approved of funding publication fees in Open Access journals with 163,000$ with the intention to encourage and assist publishing in open access journals. The fund will be managed by Lund University Libraries, Head Office. This is one of the largest funds allocated at a university in support of publishing in OA journals.

P1PK: the blood group system that changed its name and expanded.

The antigens in the P1PK blood group system are carried on glycosphingolipids. The system currently includes three different antigens, P1, Pk, and NOR. The P1 antigen was disovered in 1927 by Landsteiner and Levine, and Pk and NOR were described in 1951 and 1982, respectively. As in the ABO system, naturally occurring antibodies of the immunoglobulin (Ig) M or IgG class, against the missing carboh

Optimal control of peridinin excited-state dynamics

Optimal control is applied to study the excited-state relaxation of the carbonyl-carotenoid peridinin in solution. Phase-shaping of the excitation pulses is employed to influence the photoinduced reaction dynamics of peridinin. The outcome of various control experiments using different experimentally imposed fitness parameters is discussed. Furthermore, the effects of pump-wavelength and different