Natural and synthetic sugars have great potential for developing highly biocompatible and translatable chemical exchange saturation transfer (CEST) MRI contrast agents. In this study, we aimed to develop the smallest clinically available form of dextran, Dex1 (molecular weight, MW ~ 1 kDa), as a new CEST agent. We first characterized the CEST properties of Dex1 in vitro at 11.7 T and showed that t

This paper provides a theoretical model that captures the essential features of a Swedish health care reform where private and public health care providers serve patients with certain functional impairments, but where only private providers can reject service requests from patients. Since the hourly price compensation is fixed, this type of systems is expected to result in a monetary deficit for p

In this article, we propose a new estimator of panel data models with interactive fixed effects and multiple structural breaks that is suitable when the number of time periods, T, is fixed and only the number of cross-sectional units, N, is large. This is done by viewing the determination of the breaks as a shrinkage problem, and to estimate both the regression coefficients, and the number of brea

This paper presents an approach for optimizing floor plans using data collected from workplaces and a physics-based planning algorithm utilizing GPU-acceleration. The approach is compared to two approaches based on Genetic Algorithms and Particle Swarm Optimization. Common objectives, such as minimizing distance between related departments and daylight usage are optimized using the physics-based m

This paper investigates the FPGA resources for the implementation of in-cycle closed-loop combustion control algorithms. Closed-loop combustion control obtains feedback from fast in-cylinder pressure measurements for accurate and reliable information about the combustion progress, synchronized with the flywheel encoder. In-cycle combustion control requires accurate and fast computations for their

This paper performs a numerical study regarding the effects of different kinds of coolants on flow and heat transfer in a pin-finned internal channel. A new pin-fin structure detached from one endwall with a round-tip is proposed which aims to increase the heat transfer enhancement. As a contrast, the investigation of the typical fully-attached pin-fin and the flat-tip detached pin-fin is also con

The ongoing development of the Global Carbon Project (GCP) global methane (CH4) budget shows a continuation of increasing CH4 emissions and CH4 accumulation in the atmosphere during 2000–2017. Here, we decompose the global budget into 19 regions (18 land and 1 oceanic) and five key source sectors to spatially attribute the observed global trends. A comparison of top-down (TD) (atmospheric and tran

The archaeological site of Fracción Mujular is composed of several small residential plaza groups and a monumental ballcourt located near the Pacific Coast of Chiapas, Mexico. Long known for the Central Mexican iconography found on its carved stelae (Navarrete 1976, 1986; García-Des Lauriers 2005, 2007, 2016; Taube 2000), the survey and excavations conducted during the course of this dissertation

Vertical III-V heterostructure MOSFETs exhibit outstanding performance at reduced supply voltages. In this paper, we report on a novel process of extending high-speed device operation towards higher voltages. The device vertical geometry allows for engineering a field plate by covering the nanowire drain area with a 10-nm-thick SiO2 film. The film acts as a field moderator in the device drain regi

Objectives: To compare the short- and long-term emotional distress (grief, anxiety and depressive symptoms) after early miscarriage and satisfaction with treatment between women randomized to expectant management vs vaginal misoprostol treatment. Methods: This was a preplanned analysis of data collected during a randomized controlled trial comparing expectant management with misoprostol treatment

A recent statement from the European-Society-for-Sexual-Medicine has highlighted the limitations of using the rat model for nerve-sparing prostatectomy. The use of young rats with no comorbidities and the early evaluation of the erectile function (EF) are deemed a source of bias. Our aim was to evaluate the long-term consequences in EF of bilateral nerve cavernous crush- injury (BNCI) in type 1 di

The influence of personality factors, school achievement goals, academic efficacy, and stressload of serious problems on final grades was studied by giving a questionnaire, The Perceived Stress and Control Assessment Scale, to 915 Swedish high school students. A new measure, Stressload Index, was created by extending the Control-Stress Index. Structural Equation Modeling analysis revealed that the

Aquaporins are water channel proteins facilitating passive transport of water across cellular membranes. Aquaporins are over- or ectopically expressed in a multitude of cancers, including pancreatic ductal adenocarcinoma, which is a highly aggressive cancer with low survival rate. Evidence suggests that aquaporins can affect multiple cellular processes involved in cancer development and progressio

We study residual polynomials, Rx0,n(e), e⊂ R, x∈ R\ e, which are the degree at most n polynomials with R(x) = 1 that minimize the sup norm on e. New are upper bounds on their norms (that are optimal in some cases) and Szegő–Widom asymptotics under fairly general circumstances. We also discuss several illuminating examples and some results in the complex case such as root asymptotics, a universal

Objectives: In this proof of concept study, a deep learning–based method for automatic analysis of digital mammograms (DM) as a tool to aid in assessment of neoadjuvant chemotherapy (NACT) treatment response in breast cancer (BC) was examined. Methods: Baseline DM from 453 patients receiving NACT between 2005 and 2019 were included in the study cohort. A deep learning system, using the aforementio

Background Alcohol use disorder (AUD) is clinically heterogeneous. We examine its potential genetic heterogeneity as a function of sex, age, clinical features and mode of ascertainment. Methods In the Swedish population born 1932-1995 (n = 5 829 952), we examined the genetic risk profiles for AUD, major depression (MD), anxiety disorders, bipolar disorder, drug use disorder (DUD), attention defici

We describe a case of an adolescent male with Niemann-Pick Type C (NP-C), a neurodegenerative lysosomal lipid storage disorder, who presented with recurrent catatonia which required repeated treatment with electroconvulsive therapy (ECT). During the ECT-course, seizure threshold increased substantially, leading to questions about the influence of NP-C on neuronal excitability. In this exemplary EC

PREMIERE: Premiered by Hu Liu during the 2017 China-ASEAN Music Week at the Guangxi University of the Arts on May 28th.NOTE:Imitating the Vivacity of the Human Voice, is a meditation on diversity and the roiling of coexistence. In this piece disparate components from east and west do not suggest a transcendent unification. Rather, rhetorical devices such as “Tiaogong” [跳弓] or “Schleifer” become so

Lingua-Palatal #2, has been totally recomposed in 2020, and is written for four voices that use close amplification to heighten the resonant differences between the oral and nasal cavities. This should be a very strong effect, as if the listener is actually inside the cavity. Therefore, special care must be given to the microphone type and placement. It might even be possible to put microphones in