Introduction Clinical recommendations for childhood asthma are often based on data extrapolated from studies conducted in adults, despite significant differences in mechanisms and response to treatments. The Paediatric Asthma in Real Life (PeARL) Think Tank aspires to develop recommendations based on the best available evidence from studies in children. An overview of systematic reviews (SRs) on p

Nuclear technology and the use of radiation sources have been extensively adopted in the modern world. Despite that, a number of radiological accidents, significantly affecting population and the environment, has happened. Few of the most known are accidents in Chernobyl and Fukushima nuclear power plants. As a result, significant areas are still contaminated with some residential areas evacuated.

In popular imagery, the former Habsburg province of Galicia and its capital city Lemberg/Lwów/Lviv have been acclaimed for their unique mixture of religions, cultures and nationalities. However, there are also darker sides of this Galician diversity, as became evident during the wars and crises of the first half of the twentieth century. It is instructive to explore how the entanglements between c

Background and Objectives: Non-invasive assays for predicting foetal blood group status in pregnancy serve as valuable clinical tools in the management of pregnancies at risk of detrimental consequences due to blood group antigen incompatibility. To secure clinical applicability, assays for non-invasive prenatal testing of foetal blood groups need to follow strict rules for validation and quality

The aim of this article is to provide an evolutionarily grounded explanation of central aspects of the structure of language. It begins with an account of the evolution of human causal reasoning. A comparison between humans and non-human primates suggests that human causal cognition is based on reasoning about the underlying forces that are involved in events, while other primates hardly understan

The Bicoid (Bcd) protein is a primary determinant of early anterior-posterior (AP) axis specification in Drosophila embryogenesis. This morphogen is spatially distributed in an anterior-high gradient, and affects particular AP cell fates in a concentration-dependent manner. The early distribution and dynamics of the bicoid (bcd) mRNA, the source for the Bcd protein gradient, is not well understood

Cities are expected to contribute to climate mitigation by providing effective climate policy actions in a multilevel governance context. Yet, it is unclear what we actually know about the strengths and weaknesses of urban climate policy measures and how municipal policy learning could be enhanced. In this article we present a comprehensive review on cities’ experience in climate mitigation policy

Mechanical loading affects tendon healing and recovery. However, our understanding about how physical loading affects recovery of viscoelastic functions, collagen production and tissue organisation is limited. The objective of this study was to investigate how different magnitudes of loading affects biomechanical and collagen properties of healing Achilles tendons over time. Achilles tendon from f

This article examines the factors explaining whether or not Swedish social workers experience technostress, and highlights examples of situations when social workers experience it. The article draws on a web survey (N = 523) via a quantitative analysis of responses and a qualitative analysis of answers to an open-ended question. Approximately one-third of social workers surveyed experienced techno

Hepatocellular carcinoma (HCC), the third major cause of cancer mortality, can result from non-alcoholic steatohepatitis (NASH). Due to limited efficacy of drugs approved for HCC and no drug available yet for NASH, identification of new effective treatments is crucial. Here, we investigated whether NV556, a cyclophilin inhibitor derived from sanglifehrins, would decrease the development of NASH an

This study critically evaluates David Harvey’s model of urban land rent and its centrality in his explanation of the material forces that underlie and limit urban land policies, strategies, planning decisions, and investment choices. Harvey emphasizes structural forces of capital in relating economic urbanization processes to uneven patterns of capitalist development, recurrent economic crises of

Antibodies are central to acquired immunity against malaria. Plasmodium falciparum elicits antibody responses against many of its protein components, but there is also formation of antibodies against different parts of the red blood cells, in which the parasites spend most of their time. In the absence of a decisive intervention such as a vaccine, people living in malaria endemic regions largely d

Shot over a six-year period (2009-15) mainly in the industrial heartland of south China, a major hub in the global supply chain, this film follows labor activists as they find common grounds with workers, helping them to negotiate with local officials and factory owners over wages and working conditions. Threats, attacks, detention and boredom become part of their daily lives as they struggle to s