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BackgroundThe Parkinson's Disease (PD) Home Diary (HD) is a common clinical outcome measure, but studies show only fair agreement between clinical observer and patient assessments, with no significant improvement after patient training.ObjectivesTo investigate the agreement between a clinical observer and relatives of PD patients when assessing the patient's motor status in the HD. Agreement was a
During the recent decades, through the emerging of pump-based Parkinson (PD) therapies, it has been increasingly possible to manage motor fluctuations and dyskinesias, providing a stable levodopa plasma concentration. This can be carried out by continuous delivery of levodopa-carbidopa intestinal gel (LCIG) or levodopa-entacapone-carbidopa intestinal gel (LECIG) via a percutaneous endoscopic gastr
The coupling between sleep-awake and dark-light cycles has played an important role in understanding external and internal biological clocks. However, how functional patterns of brain regions involved in these two coupled cycles deteriorate from circadian rhythm disturbance to circadian rhythm sleep disorder remains largely unexplored in neuroimaging research. In this study, we built a whole-brain
To effectively treat motor fluctuations and dyskinesia in advanced Parkinson's disease (PD), intestinal levodopa therapy can be carried out by continuous delivery of levodopa-carbidopa intestinal gel (LCIG; Duodopa®). LCIG is delivered with a portable pump system over tubing, entering the stomach through a percutaneous endoscopic gastrojejunostomy (PEG-J) and continuing to the proximal part of the
Triacylglycerol (TAG) serves as the primary storage lipid in plants, essential for seed germination and early seedling development. Acyl-CoA:diacylglycerol acyltransferase (DGAT) enzymes catalyze the last step in TAG synthesis by converting diacylglycerol (DAG) to TAG. Although functionally conserved across species, DGATs exhibit variations in substrate preference, among their other properties, hi
With the expected further electrification of society, a greater electricity demand is to be expected, requiring improved flexibility. One proposal that meets these demands is the adaptation of the current district heating power plants by adding condensing tail turbines. Condensing tail turbines allow for further expansion of steam. A simple economic analysis showed that implementing a condensing t
The X-ray solution scattering from water S(Q)H2O depends on temperature and density, a phenomenon that is utilized in, for example, temperature-resolved and ultrafast time-resolved X-ray solution scattering experiments. Whether this contribution to the acquired data arising from changes in scattering from water is merely a background signal to be subtracted or the primary subject of investigation,
Study region: The Missouri River Basin, located between the states of Nebraska and Iowa, USA. Study focus: Water level (WL) and discharge (Q) are key hydrological variables, accurate prediction of which in both long-term and short-term (extreme events) scenarios is essential for water resources and flood risk management. We propose a novel hybrid deep learning architecture, CNN-NLSTM-SA, which int
Quantum measurements under realistic conditions reveal only partial information about a system. Yet, by performing sequential measurements on the same system, additional information can be accessed. We investigate this problem in the context of semi-device-independent randomness certification using sequential maximum-confidence measurements. We develop a general framework and versatile numerical m
Rotation is a natural tool in ultracold gases to break time-reversal symmetry, yet its impact on the collective excitations of supersolids remains largely unexplored. We show theoretically that tuning the rotation frequency, rather than the interparticle interactions, can trigger the superfluid-to-supersolid transition in Bose-Einstein condensates. Computing excitation spectra in the presence of v
According to defenders of the popular buck-passing account of value (the BPA of value), values should be understood in terms of reasons for pro- and con-responses. While much has been said about how to understand the normative component of the BPA of value, that is, how to understand ‘reasons’, including how to distinguish between reasons that imply value (the ‘right’ kind of reasons) and those th
Previous research underscores the importance of addressing biodiversity loss within environmental justice, introducing the concept of multi-species justice (MSJ) to recognise the rights and agency of non-human species. Despite its theoretical foundation, practical applications of MSJ remain underexplored. This paper contributes to operationalising MSJ in climate adaptation by exploring barriers to
Background: Ensuring that national governance and healthcare systems include the organization and provision of palliative care in all care settings for all patients in need is a global imperative. In cancer care, early palliative care can improve quality of life for patients and families and receiving specialised palliative care increases opportunities for care and death in the preferred place, wh
Psoriasiform eruptions have been described in patients treated with dupilumab. This case report describes an adolescent with severe atopic dermatitis who developed a widespread psoriasiform dermatitis 8 months after starting dupilumab. His therapy was switched to abrocitinib resulting in near-complete resolution of the psoriatic lesions with good atopic dermatitis control. This case adds to the li
Regional carbon dioxide (CO₂) and methane (CH₄) source contributions were analysed at two European coastal observatories, El Arenosillo (ARN) in southwestern Spain and Capo Granitola (CGR) in southern Italy, using in situ observations and STILT model simulations from 2006 to 2023, enabling source attribution to biogenic, fossil fuel, anthropogenic, and natural contributions. Model-observation agre
This essay intended to analyze and compare assemblages of both anthropomorphic and zoomorphic clay figurines of Pitted Ware Culture settlements in order to gain insight into how these two types of figurines were handled in comparison to each other in these particular, less common contexts. The compared aspects included quantities of the motifs, fragmentation and find context. Through comparison of
This thesis explores the concept of reuse during prehistory in relation to megalithic tombs, using three passage graves in Södervidinge, Skåne, as a case study. Using a landscape theoretical framework and a phenomenological perspective, the study analyses the spatial relationships between the graves, their relationship to the surrounding landscape, and the experience of the place. The results show
Public execution sites have long remained overlooked within Swedish archaeological research. Only a limited number out of the estimated 500-600 sites have been systematically investigated archaeologically. The public execution sites are strongly associated with death and violence, sanctioned by both the Church and the state, positioning them within what can be conceptualised as dark heritage. This
This thesis compares two qualities of flint, one more fine-grained and one more coarse-grained, from the Late Mesolithic Ertebølle site Skateholm I in Scania, Sweden. This in order to investigate what roles the different qualities of flint had in the technological organisation relating to raw material acquisition, choice of technology, and end-product goals. Through a technical analysis of the fli
The following study provides a comparative analysis of Graeco-Bactrian issues in relation to the coinage of earlier and contemporary Hellenistic dynasties, within an iconological and semiotic theoretical framework. This thesis examines the visual strategies employed by Graeco-Bactrian rulers in their attempts to construct royal legitimacy. Through the close examination of 52 extant Hellenistic coi
