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Immune responses elicited by apoB-100-derived peptides in mice

Peptides derived from apolipoprotein B (apoB)-100 have been previously used in vaccine preparations to treat atherosclerosis. Such vaccines have been shown to reduce atherosclerotic plaque development by 50 % in experimental animals, and this effect is associated with induction of T helper (Th)2 immune responses. In this study we immunised apolipoprotein E-deficient (apoE(-/-)) mice with apoB-100-

Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia

Genome-wide association studies have identified common variants that only partially explain the genetic risk for type 2 diabetes (T2D). Using genome-wide association data from 1,376 French individuals, we identified 16,360 SNPs nominally associated with T2D and studied these SNPs in an independent sample of 4,977 French individuals. We then selected the 28 best hits for replication in 7,698 Danish

Early-stage finance and the role of external entrepreneurs in the commercialization of university-generated knowledge

The past decade has seen a plethora of policy initiatives that seek to bridge the chasm between investments in public R&D and its effective diffusion in society. This article uses a case study approach to explore and contrast the effectiveness of different entrepreneur models in financing and developing university spin-offs (USOs). The distinction between different entrepreneur models is based

Total apolipoprotein E levels and specific isoform composition in cerebrospinal fluid and plasma from Alzheimer's disease patients and controls

The apolipoprotein E (ApoE) epsilon 4 allele is the strongest risk factor of sporadic Alzheimer's disease (AD), however, the fluid concentrations of ApoE and its different isoforms (ApoE2, ApoE3 and ApoE4) in AD patients and among APOE genotypes (APOE epsilon 2, epsilon 3, epsilon 4) remain controversial. Using a novel mass spectrometry-based method, we quantified total ApoE and specific ApoE isof

Risk assessment for preeclampsia in nulliparous women at 11-13weeks gestational age: prospective evaluation of two algorithms

ObjectiveTo evaluate two algorithms for prediction of preeclampsia in a population of nulliparous women in Norway. DesignProspective screening study. SettingNational Centre for Fetal Medicine in Trondheim, Norway. PopulationFive hundred and forty-one nulliparous women. MethodsThe women were examined between 11(+0) and 13(+6)weeks with interviews for maternal characteristics and measurements of mea

Social capital, political trust and daily smoking and smoking cessation: A population-based study in southern Sweden.

OBJECTIVES: To investigate the associations between vertical (institutional) political trust in the Riksdag and daily smoking and smoking cessation. STUDY DESIGN: Cross-sectional study. METHODS: In total, 27,757 individuals aged 18-80 years answered a postal questionnaire, which represents 59% of the random sample. A logistic regression model was used to investigate the associations between politi

European Trauma: Governance and the Psychological Moment

This article examines the unfolding of traumas as structural and sociopsychological narratives focused on the bordering of identity and the governing of past present and future. Proceeding from a Lacanian conception of trauma and a Foucauldian understanding of governmentality, the analysis is centered on hegemonic counternarratives, even crises, involving the bordering of both Islam/Muslim identit

Gonadal sex steroid status and bone health in middle-aged and elderly European men

The influence of sex steroids on calcaneal quantitative ultrasound (QUS) parameters was assessed in a population sample of middle-aged and elderly European men. Higher free and total E-2 though not testosterone, were independently associated with higher QUS parameters. The aim of this study was to investigate the association between QUS parameters and sex steroids in middle-aged and elderly Europe

The Landscape of Candidate Driver Genes Differs between Male and Female Breast Cancer.

The rapidly growing collection of diverse genome-scale data from multiple tumor types sheds light on various aspects of the underlying tumor biology. With the objective to identify genes of importance for breast tumorigenesis in men and to enable comparisons with genes important for breast cancer development in women, we applied the computational framework COpy Number and EXpression In Cancer (CON

Import flows: extraregional linkages stimulating renewal of regional sectors?

We examine the role of regional import flows for renewal of regional industries. The hypothesis is that imports stimulate renewal of local industries by being vehicles for technology diffusion and means by which local firms can exploit advantages of global specialisation. We find robust and positive relationships between high-quality imports and renewal of regional exports, where the latter are me

Aortic stenosis and mitral regurgitation as predictors of atrial fibrillation during 11 years of follow-up

Background: There is limited information about any association between the onset of atrial fibrillation (AF) and the presence of valvular disease. Methods: We retrospectively examined 940 patients in sinus rhythm, examined by echocardiography in 1996. During 11 years of follow-up, we assessed the incidence of AF and outcome defined as valvular surgery or death, in relation to baseline valvular fun

Enterostatin deficiency increases serum cholesterol but does not influence growth and food intake in mice

Miller R, D'Agostino D, Erlanson-Albertsson C, Lowe ME. Enterostatin deficiency increases serum cholesterol but does not influence growth and food intake in mice. Am J Physiol Endocrinol Metab 297: E856-E865, 2009. First published July 21, 2009; doi:10.1152/ajpendo.91008.2008.-A pentapeptide released from procolipase, enterostatin, selectively attenuates dietary fat intake when administered periph

Adults with mild to moderate depression exhibit more alcohol related problems compared to the general adult population: a cross sectional study.

Alcohol use has been shown to interfere with treatment for depression, but consumption habits are not routinely screened in primary care. To date, few studies have compared the alcohol consumption habits of patients with depression to the general population. The purpose of this study was to compare alcohol habits in adults diagnosed with depression in primary care to the general adult population i

Brief Report: Development and Initial Testing of a Questionnaire Version of the Environmental Rating Scale (ERS) for Assessment of Residential Programs for Individuals with Autism

There is a lack of validated autism-specific outcome measures for large-scale evaluation of the effectiveness of psycho-educational programmes. To fill this gap the Environment Rating Scale (ERS) was adapted from an interview version to a staff-completed questionnaire version (ERS-Q). The ERS-Q was tested regarding data quality, validity, reliability and ease of understanding amongst 18 residentia

Physical activity and exercise during pregnancy

A physical inactive lifestyle is associated with increased prevalence of chronic diseases such as cardiovascular disease, type 2 diabetes, osteoporosis and cancer. The proportion of pregnant women with overweight or obesity is increasing rapidly across the world and this excess weight, mainly obesity, is associated with increased risk of health problems during pregnancy and in connection with chil

Irregular Ethnograpies

Ethnography has become something of a buzzword in recent years. It is talked about and invoked in disciplines ranging from anthropology and ethnology to literature, history, business administration and design studies. Textbooks that teach ethnography tend to imbue students with the impression that ethnography is a mode of systematic investigation by which the researcher gets closer to the realitie