This article examines how the common law tort of negligence as developed in the United Kingdom can provide a helpful guidance for deconstructing and elucidating some of the disparate analytical issues that are subsumed under the umbrella of positive obligations under the European Convention on Human Rights (ECHR). Both frameworks, common law and ECHR, aim to delimit the circumstances where respons

Pyridinium triflate protic ionic liquids have been demonstrated to be highly dissociated, and nonstoichiometric compositions have been used in protic energy devices such as the all-organic proton battery. Herein, we use a combination of pulsed field gradient NMR spectroscopy and electrochemical impedance spectroscopy to investigate the charge transport properties of the nonstoichiometric protic io

Protected areas (PA) provide conservation benefits and ecosystem services that spill over the boundaries of jurisdictions to other regions. In this paper we analyse the foundations of and design options for ecological fiscal transfers (EFT) that may internalize such positive external effects. We propose a model for integrating ecological indicators into the intergovernmental fiscal transfer system

In this paper we analyse institutional conditions facilitating the transition towards a green economy by encouraging investment in the enhancement of natural capital and social equity, focussing especially on government interventions. Presenting a conceptual institutional model how innovation generally occurs, we depict system levels that can be influenced by government interventions to facilitate

It must be remembered that clinically important haemostasis occurs in vivo and not in a tube, and that variables such as the number of bleeding events and bleeding volume are more robust measures of bleeding risk than the results of analyses. In this narrative review, we highlight trauma, surgery, and mild induced hypothermia as three clinically important situations in which the effects of hypothe

The power of social actors to drive or block pharmaceutical uptake has been a concern in sociological debates on pharmaceuticalisation, including in the case of pandemic vaccination. We build on Steven Lukes’ three-dimensional view of power to explore the 2009 H1N1 pandemic vaccination in Sweden and Denmark – two similar countries that arrived at conflicting vaccination strategies. Drawing on inte

Datainsamling, plattformarnas betydelse och automatisering har formligen exploderat. Detta även om utvecklingen främst drivs av andra aktörer än de som förvaltar och äger fastigheter. Det är dags för fastighetsägare och förvaltare att koppla ett digitalt grepp.

Aim: Postnatal hypoglycaemia in newborn infants remains an important clinical problem where prolonged periods of hypoglycaemia are associated with poor neurodevelopmental outcome. The aim was to develop an evidence-based national guideline with the purpose to optimise prevention, diagnosis and treatment of hypoglycaemia in newborn infants with a gestational age ≥35 + 0 weeks. Methods: A PubMed sea

Introduction: Lung cancer is the leading cause of cancer death worldwide. Proteogenomics, a way to integrate genomics, transcriptomics, and proteomics, have emerged as a way to understand molecular causes in cancer tumorigenesis. This understanding will help identify therapeutic targets that are urgently needed to improve individual patient outcomes. Areas covered: To explore underlying molecular

Background: 1,6-Hexanediol diacrylate (1,6-HDDA) is a multifunctional acrylate and a potent sensitizer. Objectives: To report a case of allergic contact dermatitis caused by 1,6-HDDA in a hospital wristband. Methods: A male patient presented with eczema on his wrist where he had worn a hospital wristband. Patch testing was performed with our extended European baseline series, additional series, an

Microbes are vital in human health. It is helpful to promote diagnostic and treatment of human disease and drug development by identifying microbe-disease associations. However, knowledge in this area still needs to be further improved. In this paper, a new computational model using matrix completion to predict human microbe-disease associations (mHMDA, Fig. 1) is developed. First, we extract the

Currently, no effective targeted therapeutics exists for treatment of metastatic prostate cancer (PCa). Given that matrix metalloproteinases 9 (MMP9) and its associated vascular endothelial growth factor (VEGF) are critical for tumor vascularization and invasion under castration-resistant condition, it is therefore of great importance to define the functional association and interplay between andr

Introduction: Endoanal ultrasound is considered the gold standard when assessing the obstetric anal sphincter complex. Due to its relative intrusiveness and economic cost, other ultrasound modalities are on the rise, such as transperineal ultrasound with a convex probe. The aim of our study was to evaluate the agreement between endoanal ultrasound scores (EAUS score) and transperineal ultrasound s

We propose three different estimators that take into account the autocorrelation structure when reconciling forecasts in a temporal hierarchy. Combining forecasts from multiple temporal aggregation levels exploits information differences and mitigates model uncertainty, while reconciliation ensures a unified prediction that supports aligned decisions at different horizons. In previous studies, wei

In Sweden, almost half of the electricity produced comes from hydropower. However, the amount of water in the reservoir catchments is not evenly distributed throughout the year. During the colder months, precipitation usually falls as snow and accumulates into a snowpack. This frozen water is not available to the energy producers until the spring snow melt when as much as 70% of the annual dischar

Background: In a European study on contact allergy in the general population, it was hypothesized that the combination of contact allergy to a fragrance together with a history indicating dermatitis at exposure, and thereafter subsequent avoidance of scented products, implied a diagnosis of allergic contact dermatitis. Objectives: The primary aim of this study was to validate this hypothesis and a