Precision medicine should aspire to reduce error and improve accuracy in medical and health recommendations by comparison with contemporary practice, while maintaining safety and cost-effectiveness. The etiology, clinical manifestation and prognosis of diseases such as obesity, diabetes, cardiovascular disease, kidney disease and fatty liver disease are heterogeneous. Without standardized reportin

BackgroundStudies have shown that the risk of new-onset heart failure (HF) is higher post-implant for patients receiving right ventricular pacing.ObjectiveThis study aimed to investigate incidence, risk factors and implications for long-term prognosis of new-onset HF in patients after pacemaker-implant.MethodsPatients without preexisting HF who received a pacemaker in Sweden during the period 2005

i Ferdinand von Schirachs pjäs GUD diskuterar författaren livets avslut. Frågor som behandlas är Vem tillhör våra liv? Vem beslutar om vår död? Vem är vi? Vem vill vi vara? I Mattssons efterord skriver hon om dessa frågor utifrån ett juridiskt perspektiv.

With current environmental changes, evolution can rescue declining populations, but what happens to their interacting species? Mutualistic interactions can help species sustain each other when their environment worsens. However, mutualism is often costly to maintain, and evolution might counter-select it when not profitable enough. We investigate how the evolution of the investment in a mutualisti

At COP27, Parties agreed to establish a fund for loss and damage. During the COP28 opening plenary, the Loss and Damage Fund was operationalised. Despite this progress, significant questions about access to funding remain unanswered. We engage with a key term in the decision texts–particularly vulnerable. How Parties frame and define the term ‘particularly vulnerable’ will influence funding alloca

People in the Majority World disproportionately experience Loss and Damage (L&D) related to climate change. Policymakers and researchers are exploring ways to address L&D. However, significant knowledge gaps remain, including how to address what has been termed Non-Economic Loss and Damage (NELD). We contribute to filling this knowledge gap by analysing the NELD people are experiencing and

Emerging research on civil society elites has highlighted the presence of elitist tendencies in European civil societies with a growing concentration of political and economic resources in the hands of small groups of major organizations and leaders. Building upon this strand of research, this article aims at studying the power stratification of Italian civil society-third sector through a systema

There is a lack of studies aiming to assess cellular a disintegrin and metalloproteinase-17 (ADAM-17) activity in COVID-19 patients and the eventual associations with the shedding of membrane-bound angiotensin-converting enzyme 2 (mACE2). In addition, studies that investigate the relationship between ACE2 and ADAM-17 gene expressions in organs infected by SARS-CoV-2 are lacking. We used data from

Background: Brief Admission by self-referral (BA) is a crisis-management intervention standardized for individuals with self-harm at risk of suicide. We analyzed its health-economic consequences. Materials and methods: BA plus treatment as usual (TAU) was compared with TAU alone in a 12-month randomized controlled trial with 117 participants regarding costs for hospital admissions, coercive measur

In recent decades, the enforcement of European Union (EU) law has transitioned from being primarily the responsibility of Member States to becoming an increasingly shared or centralised task at the EU level. Drawing on the concept of legal design patterns, this article presents these two broadly understood enforcement approaches as decentralised and centralised enforcement patterns, and examines t

BACKGROUND: By causing inflammation and tissue damage, neutrophil extracellular traps (NETs) constitute an underlying mechanism of aspiration-induced lung injury, a major factor of the low utilization of donor lungs in lung transplantation (LTx).METHOD: To determine whether NET removal during ex vivo lung perfusion (EVLP) can restore lung function and morphology in aspiration-damaged lungs, gastri

Grundkomponenterna i en forskningscirkel är den egna erfarenheten, tillförda teoretiska perspektiv och forskningsrön tillsammans med deltagarnas nyfikenhet och utforskande ambitioner.

We investigated whether empathy and identification with Jews as a group is affected by a Holocaust education trip to Auschwitz-Birkenau. Data was collected before and after the trip and compared with a control group. The mean level of both perspective taking and identification with Jews as a group increased in the educational-trip group. Increased closeness to Jews as a group was related to increa

Recent development of powder-bed additive manufacturing promises to enable the production of architectural structures that combine high resolution and articulation with economies of scale. These capabilities can potentially be used for functionally graded metamaterials as part of the building envelope and structure, paving the way for new functionalities and performances. However, designing such m

Livestock guarding dogs (LGDs) have been used to protect livestock for millennia. While previous works suggested a single origin of modern LGDs, the degree and source of shared ancestry have not been tested. To address this, we generated genome-wide SNP data from 304 LGDs and combined it with public genomic data from 2,183 modern and 22 ancient dogs. Our findings reveal shared ancestry and extensi

The Horizon 2020 project EU 1.5°C Lifestyles aims to mainstream lifestyles aligned with the aspirational target of the Paris Agreement. The project analyzes lifestyle perspectives at the household level and links them to studies of relevant political and socio-economic structures at various levels of government. Within this project, Citizen Thinking Labs were organized in five EU countries to expl

Many definitions of degrowth highlight that the corresponding great and deep transformations are going to be “designed,” “planned,” and “democratic.” However, critical issues of democratic planning have only recently begun to be discussed. Considering a range of aspects of the technical and social division of labor, the article first revisits some of the main issues of market vis-à-vis planned res