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From genome-wide arrays to tailor-made biomarker readout – Progress towards routine analysis of skin sensitizing chemicals with GARD

Allergic contact dermatitis (ACD) initiated by chemical sensitizers is an important public health concern. To prevent ACD, it is important to identify chemical allergens to limit the use of such compounds in various products. EU legislations, as well as increased mechanistic knowledge of skin sensitization have promoted development of non-animal based approaches for hazard classification of chemic

Comparative Proteomic Analysis of Extracellular Vesicles Isolated by Acoustic Trapping or Differential Centrifugation

Extracellular vesicles (ECVs), including microparticles and exosomes, are submicrometer membrane vesicles released by diverse cell types upon activation or stress. Circulating ECVs are potential reservoirs of disease biomarkers, and the complexity of these vesicles is significantly lower compared to their source, blood plasma, which makes ECV-based biomarker studies more promising. Proteomic profi

Women, Wealth and Waterborne Disease: Smallholders’ Willingness to Pay for a Multiple-Use Water Scheme in Ethiopia

This article identifies factors which contribute to households’ willingness to pay for improving and protecting a multiple-use water scheme in Ethiopia. It does so through descriptive statistics, a probit model and contingent valuation methods complemented with qualitative data. Estimates suggest farmers’ willingness to pay is based on gender, the prevalence of waterborne disease, the time to coll

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Den boghistoriske afhandling »Den skandinaviske encyklopædi. Udgivelse og udformning af Nordisk familjebok og Salmonsens Konversationsleksikon« undersøger for første gang encyklopædiens historie og udvikling i Skandinavien. Fokus er frem for alt på de to standardsættende udgivelser Salmonsens Konversationsleksikon og Nordisk familjebok. Gennem deres position som Danmarks og Sveriges første nationa

A new time optimizing probabilistic load balancing algorithm in grid computing

The computing grid is a distributed parallel processing system that share and choosing resources dynamically and provide need of user operation power, cost and quality .grid management resources does as a diagnostic and assigning resources scheduling and resource monitoring in grid . Scheduling process directs tasks to suitable resources. It must take place some how that load work distributed equa

Effect of pentisomide (CM 7857) on myocardial excitation, conduction, repolarization, and refractoriness. An electrophysiological study in humans

The electrophysiological effects of pentisomide upon the intact human heart were evaluated using programmed stimulation and recording of intracardiac monophasic action potentials (MAP) in 17 patients with various ventricular arrhythmias. After i.v. administration of pentisomide, 85-135 mg, the atrial-His interval increased by 8 +/- 12 ms (p less than 0.05) during sinus rhythm and by 13 +/- 21 ms (

Social desirability and self-reported anxiety in children: An analysis of the RCMAS lie scale

There are important applied and theoretical reasons for research into the association between social desirability and self-reported anxiety in young people. The aim of this study was to examine the relationship between anxiety and social desirability in a large normative sample of 7- to 14- year-olds (N = 1,786). Participants Completed the Revised Children's Manifest Anxiety Scale and their teache

DSM-III-R anxiety disorders in children: Sociodemographic and clinical characteristics

This study investigated the characteristics of each of the specific DSM- III-R (American Psychiatric Association, 1987) anxiety disorders in a clinic sample of 188 anxiety disordered children. Characteristics examined included sociodemographic variables (age-at-intake, gender, and race of the child, and family marital and socioeconomic status) and clinical variables (disorder age-at-onset and seve

The association between sleep duration, insulin sensitivity, and β-cell function : The EGIR-RISC study

Context: In the past decade, over 3 dozen studies reported a relationship between self-reported short sleep and disturbed glucose metabolism. A study with insulin sensitivity assessed according to the gold standard hyperinsulinemic-euglycemic clamp is, however, still missing. Objective: To evaluate the cross-sectional association of sleep duration with insulin sensitivity and β-cell function in th

Vernacular architecture Reflections : Challenges and Future

Interest in vernacular structures has grown steadily over the past two decades. Vernacular structures around the world are the amalgamation of accumulated cultural, social and religious beliefs as well as practices. The valuable heritage embodied in the vernacular structures has served as sources of inspiration for centuries not only for architects, but also for a diverse, multi-disciplinary commu

Minus carbon and plus energy refugee shelter

This study discusses a proposal for a 37 m² refugeeearth shelter that could be built with the help of sevenpeople in 11 working days. The study is an experimental, participatory, living lab methodology for creating an eco-cycle shelter. The building’s skeleton is made from a minus carbon earth mix and is equipped with renewables that produce more energy than what the building consumes. No waste is

The circulatory system and a new cell type of the cephalocarid crustacean Hutchinsoniella macracantha

The circulatory system of Hutchinsoniella macracantha consists of a tubular heart in thoracic segments 1–6, a dorsoposterior channel, and body fluid (“haemocoelic”) sinuses. The heart, which is possibly closed anteriorly, has three paired ostia dorsolaterally in thoracic segments 2–4. The heart wall is formed by two cellular layers: an inner myocardium and an outer epicardium. The myofibrils are o

Baring it all- undressing Cambrian ´Orsten´phosphatocopine arthropods using synchrotron X-ray tomographic microscopy

Synchrotron radiation X-ray tomographic microscopy (SRXTM) was used to virtually dissect and peel the shields off of the microscopic, bivalved phosphatocopine crustaceans in the Cambrian ‘Orsten’ type of preservation of Sweden. Doing so opened up for an array of concealed internal structures to be observed in a fully enclosed specimen of Hesslandona ventrospinata and a semi-enclosed specimen of He