High-risk neuroblastoma (NB) is a significant clinical challenge. MYCN and Anaplastic Lymphoma Kinase (ALK), which are often involved in high-risk NB, lead to increased replication stress in cancer cells, suggesting therapeutic strategies. We previously identified an ATR (ataxia telangiectasia and Rad3-related)/ALK inhibitor (ATRi/ALKi) combination as such a strategy in two independent genetically

This article investigates the media lives of a particular class taxonomy in the Swedish press from 1945 to 1976. Invented by the Central Bureau of Statistics in 1911, the ‘social group division’ system was abandoned in the early post-war period. Around the same time, however, it gained popularity in Swedish culture and political debate. While earlier research has noted that such bureaucratic class

Current food systems pose one of the greatest health and environmental challenges of the 21st century. Expanded utilization of seaweed for food in Western societies seems like one promising measure in the transition toward sustainable food systems. However, introducing and expanding seaweed to new markets brings certain challenges, such as limited food acceptance and availability. In this pilot coCurrent food systems pose one of the greatest health and environmental challenges of the 21st century. Expanded utilization of seaweed for food in Western societies seems like one promising measure in the transition toward sustainable food systems. However, introducing and expanding seaweed to new markets brings certain challenges, such as limited food acceptance and availability. In this pilot co

Four new superdeformed bands have been found in the nucleus [Formula Presented]. The good agreement between experiment and configuration-dependent shell correction calculations suggests that three of the bands have triaxial superdeformed shapes. Such unique features in mass [Formula Presented] superdeformed bands have been predicted, but not observed experimentally until now. A fourth band in [For

The configuration-dependent shell-correction approach with the cranked Nilsson potential is employed for a systematic investigation of the high-spin spectra of the nuclei in the A ∼ 135 (Z = 57-61, N = 72-78) mass region, where superdeformed bands have been observed. Main attention is paid to the coexistence of intruder νi13/2, superdeformed and terminating bands in the yrast region. Recent develo

Using new high-resolution data of CO (2-1), H and H obtained with the Northern Extended Millimeter Array (NOEMA) and the Multi-Unit Spectroscopic Explorer (MUSE) at the Very Large Telescope, we have performed a Toomre Q disc stability analysis and studied star formation, gas depletion times and other environmental parameters on sub-kpc scales within the z ∼0 galaxy SDSS J125013.84+073444.5 (LARS 8

A decoupled rotational band with an average dynamical moment of inertia [Formula Presented] [Formula Presented]/MeV has been observed to high spin in [Formula Presented] [Formula Presented]. The measured quadrupole moment of [Formula Presented] eb is as large as that of the superdeformed band in [Formula Presented]. The large deformation and decoupled character of the band suggests that the odd ne

The switch process alternates independently between 1 and −1 , with the first switch to 1 occurring at the origin. The expected value function of this process is defined uniquely by the distribution of switching times. The relation between the two is implicitly described through the Laplace transform, which is difficult to use for determining if a given function is the expected value function of s

We report on a computational study of resonant inelastic x-ray scattering (RIXS), at different fluorine K-edge resonances of the SF6 molecule, and corresponding nonresonant x-ray emission. Previously measured polarization dependence in RIXS is reproduced and traced back to the local σ and π symmetry of the molecular orbitals and corresponding states involved in the RIXS process. Also electron-hole

Radioembolization with 166Ho microspheres is a minimally invasive procedure in which radioactive microspheres are administered directly to liver tumor via the hepatic artery during an interventional radiological procedure. Scout and therapeutic doses of 166Ho were delivered to patients in 2022 and 2023 at VilniusUniversity Hospital Santaros Klinikos. The presented study was aimed at investigating

There are different ways of dividing psychology into subdisciplines. The purpose of the present paper is to explore one specific metaperspective on psychological science, seen as having three main branches: person psychology, population psychology, and mechanism psychology, linked to three different levels of research. Person-level research focuses on psychological phenomena as experienced and ena

Den här översikten följer den svenska flickboken fram till cirka 1930. Denna existerade inte i ett vakuum; översättningar fortsatte att strömma in, och det känns naturligt att behålla ett internationellt perspektiv. Det är dock flickboken i Sverige som står i centrum, sådan den svenska läsarinnan mötte den, varför utländska verk här kommer att anges med sin översatta titel och det år det utgavs –

Prior to the operation of the first Belarussian nuclear power plant (BelNPP), the baseline of the radiation environment was determined within a radius of about 30 km from BelNPP. This independent assessment was carried out during two expeditions in 2019. In 2022, a similar survey was carried out (during the initialoperation of BelNPP) on the Lithuanian side of the boarder. Here we present the over

Numerous factors shape the evolution of protein-coding genes, including shifts in the strength or type of selection followinggene duplications or changes in the environment. Diatoms and other silicifying organisms use a family of silicon transporters(SITs) to import dissolved silicon from the environment. Freshwaters contain higher silicon levels than oceans, and marinediatoms have more efficient