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Individualized PID Control of Depth of Anesthesia Based on Patient Model Identification During the Induction Phase of Anesthesia

This paper proposes a closed-loop propofol admission strategy for depth of hypnosis control in anesthesia. A population-based, robustly tuned controller brings the patient to a desired level of hypnosis. The novelty lies in individualizing the controller once a stable level of hypnosis is reached. This is based on the identified patient parameters and enhances suppression of output disturbances, r

Nationalmuseer som tidsspegel. 2000-talets forntider i Danmark och Sverige

This is a study of two recently opened exhibitions on prehistoric times at the national museums of Denmark and Sweden respectively. It is argued that the contents of the exhibitions explicitly mirror the present discussions and political climates in each country. As a means of taking part of present times in these versions of the past, the exhibitions are extremely well suited for the purpose. In

Efficacy and safety of ipilimumab monotherapy in patients with pretreated advanced melanoma: a multicenter single-arm phase II study

Background: This phase II study evaluated the safety and activity of ipilimumab, a fully human mAb that blocks cytotoxic T-lymphocyte antigen-4, in patients with advanced melanoma. Patients and methods: Patients with previously treated, unresectable stage III/stage IV melanoma received 10 mg/kg ipilimumab every 3 weeks for four cycles (induction) followed by maintenance therapy every 3 months. The

The black box of everyday life : entanglements of stuff, affects and activities

Ethnologists like to think of themselves as masters of the study of the everyday, but we still know surprising little how this mundane machinery works. Everyday life remains something of a black box, our understanding is still piecemeal and fragmented. This paper explores cohabitation and circulation of objects, affects and activities in the home - seen as a workshop where raw materials, raw feeli

Strong Inbreeding Depression in Two Scandinavian Populations of the Self-Incompatible Perennial Herb Arabidopsis Lyrata

Inbreeding depression is a key factor influencing mating system evolution in plants, but current understanding of its relationship with selfing rate is limited by a sampling bias with few estimates for self-incompatible species. We quantified inbreeding depression () over two growing seasons in two populations of the self-incompatible perennial herb Arabidopsis lyrata ssp. petraea in Scandinavia.

Thrombosis in Children

Aims: The general objective was to further elucidate thromboembolic disease in children and thereby help improve the care of these patients. More specific aims were as follows: to determine what children are affected by thrombosis; to discern any gender or age differences related to thrombosis; to identify prothrombotic risk factors; to ascertain whether autoantibodies against coagulation proteins

Crypt fission contributes to postnatal epithelial growth of the small intestine in pigs

Studies on growth of the small intestine have mostly concentrated on crypt hyperplasia rather than crypt fission (CF). The process of crypt bifurcation has been identified in rodents and humans but not in swine. The main aims of this study were: 1) to investigate quantitatively crypt fission in the small intestine mucosa of pigs of different age-groups and 2) to assess the effect of colostrum and

Impersonal null-subjects in Icelandic and elsewhere

We study the properties of impersonal null-subjects, in particular in Icelandic, exploring the idea that such elements are constructed in syntax (rather than being lexical pronouns deleted in PF). In addition, we discuss the cross-linguistic distribution of impersonal null-subjects.

Relative Sources of European Regional Productivity Convergence: A Bootstrap Frontier Approach

Enflo K. and Hjertstrand P. Relative sources of European regional productivity convergence: a bootstrap frontier approach, Regional Studies. This paper addresses the issue of Western European regional productivity growth and convergence by means of data envelopment analysis (DEA), decomposing labour productivity into efficiency change, technical change and capital accumulation. The decomposition s

How dim is dim? Precision of the celestial compass in moonlight and sunlight.

Prominent in the sky, but not visible to humans, is a pattern of polarized skylight formed around both the Sun and the Moon. Dung beetles are, at present, the only animal group known to use the much dimmer polarization pattern formed around the Moon as a compass cue for maintaining travel direction. However, the Moon is not visible every night and the intensity of the celestial polarization patter

Warfarin dose prediction in children using pharmacometric bridging-comparison with published pharmacogenetic dosing algorithms

Numerous studies have investigated causes of warfarin dose variability in adults, whereas studies in children are limited both in numbers and size. Mechanism-based population modelling provides an opportunity to condense and propagate prior knowledge from one population to another. The main objectives with this study were to evaluate the predictive performance of a theoretically bridged adult warf

A Gaussian Markov random field model for total yearly precipitation over the African Sahel

A spatio-temporal model is constructed to interpolate yearly precipitation data from 1982 to 1996 over the African Sahel. The precipitation data used in the analysis comes from the Global Historical Climatology Network. The spatio-temporal model is based on a Gaussian Markov random field approach with AR(1)-dependence in time and a spatial component modeled using an approximation of a field withMa

B-10 multi-grid proportional gas counters for large area thermal neutron detectors

He-3 was a popular material in neutrons detectors until its availability dropped drastically in 2008. The development of techniques based on alternative convertors is now of high priority for neutron research institutes. Thin films of B-10 or (B4C)-B-10 have been used in gas proportional counters to detect neutrons, but until now, only for small or medium sensitive area. We present here the multi-