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Impact of timing of prophylaxis commencement, F8 genotype and age on factor consumption and health-related quality of life in patients with severe haemophilia A

Introduction: The timing of prophylaxis and F8 genotype can impact treatment outcomes in adults with severe haemophilia A (HA). Aim: To investigate how F8 genotype, timing, and type of prophylaxis influence arthropathy, bleeding rates, factor consumption and health-related quality of life (HRQoL). Methods: Thirty-eight patients with severe HA were enrolled. Bleeding events were recorded retrospect

Operational loss estimation in irrigation canals by integrating hydraulic simulation and crop growth modeling

Identifying operational losses in irrigation canals can be difficult due to inaccurate simplification in designing and operating national guidelines. However, this study aims to provide a practical solution to this problem by identifying operational losses, which are the primary cause of off-farm irrigation water losses. The method involves simulating the daily delivered water to individual Irriga

Managers’ understanding of agile in hardware development

The agile methodology is gaining attention among practitioners and researchers in hardware development. As a new methodology, it is a source of misunderstandings and misinterpretations. This is problematic at the managers' levels as they may hinder its adoption or lead to its impractical implementation and use. This study, therefore, aims to explore the manager's level of understanding of the agil

Long-Term Follow-up and Risk of Recurrence of Internal Herniation after Roux-en-Y Gastric Bypass

Purpose: Internal herniation (IH) is the most common complication after Roux-en-Y gastric bypass surgery (RYGB). Although primary closure has reduced the incidence, recurrences are a continued problem. This study aimed to investigate long-term follow-up and recurrence risk of IH surgery. Methods: A retrospective cohort study of laparoscopic RYGB operated patients operated for a first IH between Ap

Mass transfer and modeling of deformed bubbles in square microchannel

Understanding of mass transfer in gas-liquid slug flow is imperative to design and optimize micro-reactors. There exist extensive studies on symmetric bubbles by the phase volume monitor technique, whereas deformed bubbles are rarely studied due to the limitation of volume calculation methods. In this work, CO2-water and N2-water two-phase flows were investigated in a square microchannel, obtainin

Teaching the Subject of Nursing—Academic Teaching Based on Dossey's Holistic Nursing Theory

Introduction: Being a teacher of nursing education can be challenging. Nursing theories can guide clinical nurses in their work, but is it possible to apply a nursing theory in the context of academic teaching? Purpose: To investigate if it is possible to apply Dossey's holistic nursing theory into the context of teaching the subject of nursing. Conclusion: This article proposes that Dosseys holis

4D Flow cardiovascular magnetic resonance consensus statement : 2023 update

Hemodynamic assessment is an integral part of the diagnosis and management of cardiovascular disease. Four-dimensional cardiovascular magnetic resonance flow imaging (4D Flow CMR) allows comprehensive and accurate assessment of flow in a single acquisition. This consensus paper is an update from the 2015 ‘4D Flow CMR Consensus Statement’. We elaborate on 4D Flow CMR sequence options and imaging co

Fertility patterns and sex composition preferences in immigrant–native unions in Sweden

Intermarriage between immigrants and native individuals highlights the need to study childbearing as a joint decision of couples, because fertility preferences are likely to differ for the two partners involved. This study focuses on Sweden, where the majority population holds a relative preference for daughters but many immigrants come from countries with son preferences. Using longitudinal regis

A multiparametric approach to predict triple-negative breast cancer including parameters derived from ultrafast dynamic contrast-enhanced MRI

Objective: Triple-negative breast cancer (TNBC) is a highly proliferative breast cancer subtype. We aimed to identify TNBC among invasive cancers presenting as masses using maximum slope (MS) and time to enhancement (TTE) measured on ultrafast (UF) DCE-MRI, ADC measured on DWI, and rim enhancement on UF DCE-MRI and early-phase DCE-MRI. Methods: This retrospective single-center study, between Decem

Insertion of the CXXC domain of KMT2A into YAP1 : An unusual mechanism behind the formation of a chimeric oncogenic protein

Most neoplasia-associated gene fusions are formed through the fusion of the 5′-part of one gene with the 3′-part of another. We here describe a unique mechanism, by which a part of the KMT2A gene through an insertion replaces part of the YAP1 gene. The resulting YAP1::KMT2A::YAP1 (YKY) fusion was verified by RT-PCR in three cases of sarcoma morphologically resembling sclerosing epithelioid fibrosa

Recombinant factor IX Fc prophylaxis reduces pain and increases levels of physical activity, with sustained, long-term improvements in patients with hemophilia B : post hoc analysis of phase III trials using patient-reported outcomes

Background: Pain is a common symptom of hemophilia that may adversely affect patients’ quality of life (QoL). Previous post hoc analyses of prophylaxis with recombinant factor IX Fc fusion protein (rFIXFc) have been published for adults and adolescents, demonstrating improvements in health-related QoL (HRQoL) when assessed by the haemophilia-specific QoL (HaemAQoL) questionnaire. Objective: To des

C4b-binding protein inhibits particulate- and crystalline-induced NLRP3 inflammasome activation

Dysregulated NLRP3 inflammasome activation drives a wide variety of diseases, while endogenous inhibition of this pathway is poorly characterised. The serum protein C4b-binding protein (C4BP) is a well-established inhibitor of complement with emerging functions as an endogenously expressed inhibitor of the NLRP3 inflammasome signalling pathway. Here, we identified that C4BP purified from human pla

Climate Change and Food Systems

Climate change affects the functioning of all of the components of food systems, often in ways that exacerbate existing predicaments and inequalities among regions of the world and groups in society. At the same time, food systems are a major cause of climate change, accounting for a third of all greenhouse gas (GHG) emissions. Therefore, food systems can and should play a much bigger role in clim

Invisible, Responsible Women in Sweden–Planning Pregnancies, Choosing Contraceptives

In this study I explore discourses of contraception and reproduction, which are drawn upon and reproduced in Swedish official online sources on contraceptive advice, through the theoretical frameworks of biomedicalization and reproductive justice. The analysis yielded three interwoven themes: 1) women in need of contraceptives have to balance discourses of exogenous hormones as both an “unnatural”

Software compatibility analysis for quantitative measures of [18F]flutemetamol amyloid PET burden in mild cognitive impairment

Rationale: Amyloid-β (Aβ) pathology is one of the earliest detectable brain changes in Alzheimer’s disease pathogenesis. In clinical practice, trained readers will visually categorise positron emission tomography (PET) scans as either Aβ positive or negative. However, adjunct quantitative analysis is becoming more widely available, where regulatory approved software can currently generate metrics

Using the auditory brainstem response elicited by within-channel gaps to measure temporal resolution

The Auditory Brainstem Response (ABR) can be used to measure the early temporal activity of the auditory system. A gapin- noise ABR has been developed to measure the electrophysiological response to auditory stimulation without attending to the task. In the present study, young adults passively listened to stimuli of various gap widths in separate sequences. In a single sequence, two identical 15

In vivo assessment of elbow flexor work and activation during stretch-shortening cycle tasks

The purpose of this study was to use an electromyography (EMG) based muscle model to investigate the performance enhancement of stretch-shortening cycle (SSC) tasks at different elbow flexion-extension velocities. A torque motor was used to oscillate the forearms of seven healthy male subjects (23-40 years) during SSC and non-SSC contractions at four frequencies of movement (.58, 1.5, 2.4 and 3.3

Altered postural control during the luteal phase in women with premenstrual symptoms

The purpose of this study was to investigate postural control in women with and without premenstrual symptoms (PMS) in three hormonally verified phases of the menstrual cycle. Thirty-two women were recruited to participate in the study and 25 of these women were included in the results. Menstrual cycle phases were determined by sex hormone analyses in serum and LH detection in urine. A prospective

Sex differences in muscle activation patterns associated with anterior cruciate ligament injury during landing and cutting tasks : A systematic review

Neuromuscular control is critical for maintaining dynamic joint stability and mitigating the risk of anterior cruciate ligament (ACL) injury. Given the increased risk of ACL injury in females, sex-based differential muscle activation strategies are often associated with this risk. For example, the quadriceps-dominant muscle activation strategy sometimes observed in females has been discussed as a

A hierarchy in functional muscle roles at the knee is influenced by sex and anterior cruciate ligament deficiency

Background: Sex-related neuromuscular differences have been linked to greater risk of anterior cruciate ligament injuries in females. Despite this, it remains unclear if sex-related differences are present after injury. This study sought to determine if sex differences are present in the functional roles of knee joint muscles in an anterior cruciate ligament deficient population. Methods: An isome