OBJECTIVE: The capability of the protein NEDD4L to reduce renal tubular expression of epithelial Na+ channel (ENaC) is influenced by a functional rs4149601 G→A NEDD4L polymorphism. As diuretics and β-blockers inhibit renal sodium reabsorption and renin release, respectively, we hypothesized that the β-blocker or diuretic-induced blood pressure reduction and prevention of cardiovascular disease wou

It is commonly assumed that European integration empowers prime ministers at the expense of cabinet ministers and parliamentary actors. This article follows the suggestion that an increase in cabinet reshuffles indicates power shifts in favour of the PM, and studies reshuffles in two countries that have been involved very differently in the process of European integration, Germany and Sweden. It h

Heavy neutron-rich nuclei were populated via the fragmentation of a E/A = 1 GeV Pb-208(82) beam. Secondary fragments were separated and identified and subsequently implanted in a passive stopper. By the detection of delayed gamma rays, isomeric decays associated with these nuclei have been identified. A total of 49 isomers were detected, with the majority of them observed for the first time. The n

This PhD thesis deals with the transformation of imported vessels of Roman origin in Germania Magna during the Roman Iron Age, 1-400 AD. The concept of transformation in this context refers to the various ways these objects were interpreted, physically altered and consequently changed with regard to their function and meaning. Roman vessels in Germanic contexts are often regarded as evidence for R

Background: In recent years, several primary care databases recording information from computerized medical records have been established and used for quality assessment of medical care and research. However, to be useful for research purposes, the data generated routinely from every day practice require registration of high quality. In this study we aimed to investigate (i) the frequency and vali

Med egna radio- och TV-program, tidningar och sändningar tillgängliga på Internet formar den somaliska gruppen i Minnesota bilden av sig själv. Programmen tas fram genom ideellt arbete och bygger broar mellan kulturer.

Epilepsy comprises a family of neurological disorders characterized by recurrent seizures, which can be highly debilitating. Up to 30% of patients with temporal lobe epilepsy, the most common form of the disorder in adults, arising in the hippocampus, cannot be effectively treated by current pharmaceuticals. Novel treatment strategies are highly needed, as well as increased understanding of the hi

The perforated whole-cell configuration of the patch-clamp technique was applied to functionally identified beta-cells in intact mouse pancreatic islets to study the extent of cell coupling between adjacent beta-cells. Using a combination of current- and voltage-clamp recordings, the total gap junctional conductance between beta-cells in an islet was estimated to be 1.22 nS. The analysis of the cu

OBJECTIVE-Common variants in FTO (the fat mass- and obesity-associated gene) associate with obesity and type 2 diabetes. The regulation and biological function of FTO mRNA expression in target tissue is unknown. We investigated the genetic and nongenetic regulation of FTO mRNA in skeletal muscle and adipose tissue and their influence on in vivo glucose and fat metabolism. RESEARCH DESIGN AND METHO

Purpose To compare drug treatment changes in older hip fracture patients with and without multi-dose drug dispensing (MDD) after discharge from hospital. Methods Hip fracture patients (aged 65 years or older) for whom the same prescribing procedure was used at discharge and at the 6-month follow-up were extracted from two patient cohorts consecutively recruited in 2008 (n=100) and 2009 (n=99), res

Plant species beta diversity is influenced by spatial heterogeneity in the environment. This heterogeneity can potentially be characterised with the help of remote sensing. We used WorldView-2 satellite data acquired over semi-natural grasslands on The Baltic island of Öland (Sweden) to examine whether dissimilarities in remote sensing response were related to fine-scale, between-plot dissimilarit

Background: Muscle function may influence the risk of knee injury and outcomes following injury. Clinical tests, such as a single-limb mini squat, resemble conditions of daily life and are easy to administer. Fewer squats per 30 seconds indicate poorer function. However, the quality of movement, such as the medio-lateral knee motion may also be important. The aim was to validate an observational c

Chondroitin sulfate (CS) and dermatan sulfate (DS) are expressed in significant amounts in the brain and play important roles in the development of the central nervous system in mammals. CS and DS structures are often found in a single CS/DS hybrid chain. The L-iduronic acid (IdoA)-containing domain, which defines a DS-type domain, appears key to the biological functions of the CS/DS hybrid chain.

The microarchitecture of trabecular bone adapts to its mechanical loading environment according to Wolff's law and alters with age. Trabecular bone is a metabolically active tissue, thus, its molecular composition and microarchitecture may vary between anatomical locations as a result of the local mechanical loading environment. No comprehensive comparison of composition and microarchitecture of t

Background: Long-term exposure to air pollution is a hypothesized risk factor for ischemic stroke. In a large case-control study with a complete study base, we investigated whether hospital admissions for ischemic stroke were associated with residential concentrations of outdoor NOx, as a proxy for exposure to air pollution, in the region of Scania, Southern Sweden. Methods: We used a two-phase ca

An apparent relation between the lift-off length under diesel conditions and the ignition quality of a fuel has previously been reported. To cast light on the underlying mechanism, the current study aims to separate flame lift-off effects of the chemical ignition delay from those of other fuel properties under diesel conditions. Flame lift-off was measured in an optical diesel engine by high-speed

Genetic studies have shown that mutations of complement inhibitors such as membrane cofactor protein, Factors H, I, or B and C3 predispose patients to atypical hemolytic uremic syndrome (aHUS). Factor I is a circulating serine protease that inhibits complement by degrading C3b and up to now only a few mutations in the CFI gene have been characterized. In a large cohort of 202 patients with aHUS, w