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Direct electron transfer of dehydrogenases for development of 3rd generation biosensors and enzymatic fuel cells

Dehydrogenase based bioelectrocatalysis has been increasingly exploited in recent years in order to develop new bioelectrochemical devices, such as biosensors and biofuel cells, with improved performances. In some cases, dehydrogeases are able to directly exchange electrons with an appropriately designed electrode surface, without the need for an added redox mediator, allowing bioelectrocatalysis

Global change-driven effects on dissolved organic matter composition : Implications for food webs of northern lakes

Northern ecosystems are experiencing some of the most dramatic impacts of global change on Earth. Rising temperatures, hydrological intensification, changes in atmospheric acid deposition and associated acidification recovery, and changes in vegetative cover are resulting in fundamental changes in terrestrial-aquatic biogeochemical linkages. The effects of global change are readily observed in alt

Smoking, body mass index, disease activity, and the risk of rapid radiographic progression in patients with early rheumatoid arthritis

BACKGROUND: Identification of risk factors for rapid joint destruction in early rheumatoid arthritis (RA) can be helpful for optimizing treatment, and improving our understanding of destructive arthritis and its mechanisms. The objective of this study was to investigate the relationship between early RA patient characteristics and subsequent rapid radiographic progression (RRP).METHODS: An incepti

Biomarkers for equine joint injury and osteoarthritis

We report the results of a symposium aimed at identifying validated biomarkers that can be used to complement clinical observations for diagnosis and prognosis of joint injury leading to equine osteoarthritis (OA). Biomarkers might also predict pre-fracture change that could lead to catastrophic bone failure in equine athletes. The workshop was attended by leading scientists in the fields of equin

Bivalirudin versus heparin with primary percutaneous coronary intervention

Background: Optimal adjunctive therapy in ST-segment elevation myocardial infarction (STEMI) patients treated with primary PCI (PPCI) remains a matter of debate. Our aim was to compare the efficacy and safety of bivalirudin to unfractionated heparin (UFH), with or without glycoprotein IIb/IIIa inhibitors (GPI) in a large real-world population, using data from the Swedish national registry, SWEDEHE

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This study comparatively analyzes the calculation performances of different large-eddy simulation (LES) combustion models in a diffused flame simulation to investigate the performances of different LES-turbulent combustion models. The flamelet/progress variable (FPV), partially stirred reactor (PaSR), and transport joint possibility density function (PDF) combustion model are adopted to perform a

Volcanic impact on the climate - The stratospheric aerosol load in the period 2006-2015

We present a study on the stratospheric aerosol load during 2006-2015, discuss the influence from volcanism and other sources, and reconstruct an aerosol optical depth (AOD) data set in a resolution of 1° latitudinally and 8 days timewise. The purpose is to include the "entire" stratosphere, from the tropopause to the almost particle-free altitudes of the midstratosphere. A dynamic tropopause of 1

BAP1 induces cell death via interaction with 14-3-3 in neuroblastoma article

BRCA1-associated protein 1 (BAP1) is a nuclear deubiquitinating enzyme that is associated with multiprotein complexes that regulate key cellular pathways, including cell cycle, cellular differentiation, cell death, and the DNA damage response. In this study, we found that the reduced expression of BAP1 pro6motes the survival of neuroblastoma cells, and restoring the levels of BAP1 in these cells f

Modelling pedestrian merging in stair evacuation in multi-purpose buildings

Despite the total evacuation time of occupants in a multi-storey building not being affected by pedestrian merging on stairs, the calculation of evacuation times in each individual floor depends on the pedestrian merging ratio. In fact, different merging ratios may cause an evacuation to take place from the top to the bottom or vice versa. A simplified simulation model for the calculation of evacu

Probing ultrafast proton induced dynamics in transparent dielectrics

A scheme has been developed permitting the spatial and temporal characterisation of ultrafast dynamics induced by laser driven proton bursts in transparent dielectrics. Advantage is taken of the high degree of synchronicity between the proton bursts generated during laser-foil target interactions and the probing laser to provide the basis for streaking of the dynamics. Relaxation times of electron

Transcutaneous oxygen pressure as a predictor for short-term survival in patients with type 2 diabetes and foot ulcers : a comparison with ankle–brachial index and toe blood pressure

Aims: Ankle–brachial index (ABI) is the most commonly used test when diagnosing peripheral vascular disease and is considered a marker for cardiovascular risk. Transcutaneous oxygen pressure (TcPO2), a test associated with microvascular function, has in several studies shown better correlation with diabetic foot ulcer (DFU) healing. Whether a low TcPO2 could be a marker for mortality in the high-r

Disembedded Openness : Inequalities in European Economic Integration at the Sectoral Level

The process of European integration resulted in a marked increase in transnational economic flows, yet regional inequalities along many developmental indicators remain. We analyze the unevenness of European economies with respect to the embedding of export sectors in upstream domestic flows and their dependency on dominant export partners. We use the WIOD dataset of sectoral flows for the period o

On the neuronal circuitry mediating l-DOPA-induced dyskinesia

With the advent of rodent models of l-DOPA-induced dyskinesia (LID), a growing literature has linked molecular changes in the striatum to the development and expression of abnormal involuntary movements. Changes in information processing at the striatal level are assumed to impact on the activity of downstream basal ganglia nuclei, which in turn influence brain-wide networks, but very little is ac

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History of the study of anomalous experiences, in portuguese.

Returning Chernivtsi to the cultural map of Europe : The Meridian Czernowitz International Poetry Festival

Drawing on tropes, stories, and symbols emanating from lost layers of urban cultural diversity has been an important resource in post-socialist city branding in many cities in Eastern and Central Europe that saw significant ethno-demographic changes in connection with World War II. In Chernivtsi, this is usually framed by narratives emphasizing tolerance, cultural diversity, and Europeanness, noti

First Measurements of Pulse Picking by Resonant Excitation (PPRE) at the MAX IV 3 GeV Storage Ring

At synchrotron light storage rings there is demand for serving high-brilliance users requesting multibunch operation while simultaneously serving timing users who require single-bunch operation. One method to accomplish this is PPRE developed and currently in user operation at BESSYII. In the method, the transverse emittance of one of the bunches in the bunch train is increased by an incoherent beAt synchrotron light storage rings there is demand for serving high-brilliance users requesting multibunch operation while simultaneously serving timing users who require single-bunch operation. One method to accomplish this is PPRE developed and currently in user operation at BESSY II. In the method, the transverse emittance of one of the bunches in the bunch train is increased by an incoherent b

Model Predictive Control (MPC) of an Advanced Multi-Cylinder Engine for Transient Operations

The transportation sector is one of the main contributors to greenhouse gas CO2 and emission of toxic gas. In this sector, advanced technologies and innovations to increase engine efficiency is an important research topic. Low-Temperature Combustion (LTC) concepts are effective approaches for high-efficiency engines. Partially Premixed Combustion (PPC) is one type of low-temperature combustion whi

From waste to high-value products: Impact of galactoglucomannan purity on selected hydrogel properties

Hydrogels are a hydrophilic network of polymers (usually cross-linked polysaccharides) that are natural or synthetic. Applications of hydrogels are many in the biomedical field. Because of the high water absorption (10 to 200 grams of water per gram of hydrogel), hydrogels have a high degree of flexibility similar to natural human tissue. Human cells can be incorporated into the hydrogel, which in

Vigvatten, signerier och prästlöften : En dispyt om kyrkobruk och vidskepelse i skuggan av Röda boken

Artikeln undersöker en teologisk traktat skriven på 1570-talet av Jesper Marci, kyrkoherde i Vadstena, (handskriften T 147 i Linköpings stiftsbibliotek), riktad mot Hans Pauli Montanus, kaplan i Vadstena kloster, och dennes enligt Jesper Marci vidskepliga bruk av vigvatten under 1570-talet. Det svenska reformatoriska prästvigningsritualet och bakgrunden till det symboliska överlämnandet av en bibe