IMPORTANCE An accurate prognosis is especially pertinent in mild cognitive impairment (MCI), when individuals experience considerable uncertainty about future progression. OBJECTIVE To evaluate the prognostic value of tau positron emission tomography (PET) to predict clinical progression from MCI to dementia. DESIGN, SETTING, AND PARTICIPANTS This was a multicenter cohort study with external valid

Background. Whether disease burden in patients with metastatic castration-sensitive prostate cancer (mCSPC) predicts treatment outcomes is unknown. We assessed apalutamide treatment effect in TITAN patients with mCSPC by disease volume, metastasis number and timing of metastasis presentation. Methods. These protocol-defined and post hoc analyses of the phase III randomised TITAN study evaluated cl

In recent times, there have been notable advancements in comprehending the potential anti-cancer effects of chrysin (CH), a naturally occurring flavonoid compound found abundantly in various plant sources like honey, propolis, and certain fruits and vegetables. This active compound has garnered significant attention due to its promising therapeutic qualities and minimal toxicity. CH’s ability to c

Background: Expiratory flow limitation (EFL) during tidal breathing and lung hyperinflation have been identified as major decisive factors for disease status, prognosis and response to therapy in obstructive lung diseases. Aim: To investigate the delta values between expiratory and inspiratory resistance and reactance, measured using respiratory oscillometry and its correlation with air trapping a

Businesses across different areas of interest areincreasingly depending on data, particularly for machine learning (ML) applications. To ensure data provisioning, interorganizational data sharing is proposed, e.g. in the form of data ecosystems. The aim of this study was to perform an exploratory investigation into the data sharing practices that existin business-to-business (B2B) and business-to-

We investigate the persistance of embedded eigenvalues under perturbations of a certain self-adjoint Schrödinger-type differential operator in L2(R; Rn), with an asymptotically periodic potential. The studied perturbations are small and belong to a certain Banach space with a specified decay rate, in particular, a weighted space of continuous matrix valued functions. Our main result is that the se

Saccharomyces cerevisiae was immobilized in calcium alginate gel together with varying concentrations of iron oxide, in the form of magnetite or a colloidal ferrite suspension, Ferrofluid™. Inclusion of magnetic material apparently had no adverse effect on the yeast cells as judged from their fermentation capacity, their operational stability as well as their ability to propagatein situ in the pre

Denna uppsats undersöker den fortsatta utvecklingen av ett potentiellt FN-fördrag om företag och mänskliga rättigheter. I år är det ett decennium sedan rådet för mänskliga rättigheter antog resolution 26/9, vilken inrättade en arbetsgrupp för att utarbeta ett potentiellt rättsligt bindande instrument inom mänskliga rättigheter, med målet att reglera transnationella företag och andra affärsverksamhThis thesis examines the continuing development of a potential UN Treaty on Business and Human Rights. This year marks a decade since the Human Rights Council passed resolution 26/9, establishing a working group to elaborate a potential legally binding instrument in international human rights law, with the objective to regulate the activities of transnational corporations and other business enterp

The world is becoming more and more data driven. There are many ways to collect, analyse and disseminate data, and data ecosystems are among the most important environments that we have for facilitating this. Spatial data is one of the data types in data ecosystems, and data ecosystems play a key role in further value creation of the spatial data created, maintained and shared in the SDI. The work

Seemingly neglected post-industrial spaces have often become crucial assets for movements seeking to inscribe new commons and public places in the urban fabric. Appropriating abandoned "Brachen" landscape or older factory complexes has allowed movements a foothold to build an urban world that is theirs. However, also movements clearly connected to industrialization, most notably the labor movement

This paper critically engages with one of Harvey's central conceptual frameworksin his model for capitalist urbanization (and its central mechanism, capitalswitching), i.e., his three circuits of capital. Harvey names Capital Vol II as hismain source of inspiration and characterizes his conceptual framework as anelaboration of Marx's original intentions in the text. I have two objectives in mycrit

This paper investigates the intersection of cognitive sciences and social network theory and its counterpart, the complexity sciences, aiming to shed light on the compatibility and potential integration of these frameworks into institutional theory. Institutional scholars have for long selectively adopted notions linked with the cognitive sciences and complexity sciences, such as the notion of pat

Shallow geothermal offers great potential to supply emission-free heating and cooling and has therefore a pivotal role in the transition of heating and cooling networks. This paper presents a novel heating and cooling network with possible geothermal energy sharing between decentralized borefields located at each building level. The system consolidates the benefits of both standalone and centraliz

Abstract This thesis is an evaluation of piezoelectric speaker drivers for loudspeaker design. It goes through the electrical and sound generating properties of the speaker drivers and general theory of piezoelectric speaker drivers. A prototype single speaker driver loudspeaker has been realized and evaluated by measuring the frequency response and sound pressure level (SPL), total harmonic disto

This study explores why the ruling elite in 18th-century Britain not only allowed but actively supported industrialization. Economic rents, political power, and international competition are commonly cited as the reasons, but these explanations lack empirical evidence. By conducting a text analysis of parliamentary legislation and debates on the cotton industry, this study demonstrates that the ru

OBJECTIVE: Twin studies have demonstrated that posttraumatic stress disorder (PTSD) is moderately heritable, and the pattern of findings across studies suggests higher heritability in females compared with males. Formal testing of sex differences has yet to be done in twin studies of PTSD. The authors sought to estimate the genetic and environmental contributions to PTSD, and to formally test for

Horse liver alcohol dehydrogenase was immobilized on glycerylpropyl-silica (10 μm, 1000-Å pores) activated with 2,2,2-trifluoroethanesulfonyl chloride (tresyl chloride). The coupling and activity yield was almost 100%. The coenzyme-binding sites were equivalent and virtually unaffected by the immobilization process, as judged from Scatchard plots and active-site titrations. The silica-bound enzyme

Genome-wide association studies (GWASs) based on common single nucleotide polymorphisms (SNPs) have identified several loci associated with the risk of monoclonal gammopathy of unknown significance (MGUS), a precursor condition for multiple myeloma (MM). We hypothesized that analyzing haplotypes might be more useful than analyzing individual SNPs, as it could identify functional chromosomal units