Diamond-Blackfan anemia (DBA) is a congenital red cell aplasia in which 25% of the patients have a mutation in the ribosomal protein (RP) S19 gene. It is not known how the RPS19 deficiency impairs erythropoiesis and proliferation of hematopoietic progenitors. To elucidate molecular mechanisms in RPS19 deficient DBA, we analyzed the effects of RPS19 deficiency on EPO induced signal transduction, ce

The current study was carried out to test the potential of a new nanomaterial (Spago Pix) as a macromolecular magnetic MR contrast agent for tumor detection and to verify the presence of nanomaterial in tumor tissue. Spago Pix, synthesized by Spago Nanomedical AB, is a nanomaterial with a globular shape, an average hydrodynamic diameter of 5 nm, and a relaxivity (r1) of approximately 30 (mM Mn)-1

OBJECTIVE-Although insulin resistance (IR) may underlie associations between depressive symptoms and diabetes, previous findings have been contradictory. We examined whether depressive symptoms associate with IR and insulin secretion, and, additionally, whether antidepressant medication use may modulate such associations. RESEARCH DESIGN AND METHODS-A total of 4,419 individuals underwent an oral g

Background: When the same dose of iodine is given to all patients when performing abdominal computed tomography (CT) there may be a wide inter-individual variation in contrast medium (CM) enhancement of the liver. Purpose: To evaluate if any of the measures body height (BH), body mass index (BMI), lean body mass (LBM), ideal body weight (IBW), and body surface area (BSA) correlated better than bod

With the advent of molecular transistors, electrochemistry can now be studied at the single-molecule level. Experimentally, the redox chemistry of the molecule manifests itself as features in the observed Coulomb blockade diamonds. We present a simple theoretical method for explicit construction of the Coulomb blockade diamonds of a molecule. A combined quantum mechanical/molecular mechanical meth

Recent PHOBOS measurements of the excitation function for the pseudo-rapidity dependence of the elliptic flow in Au + Au collisions at RHIC have posed a significant theoretical challenge. Here we show that these differential measurements, as well as the RHIC measurements on transverse momentum satisfy a universal scaling relation predicted by the Buda-Lund model, based on exact solutions of perfec

Objective. Surgical removal of the stomach (gastrectomy, Gx) leads to osteopenia in animals and in humans. In the rat, Gx adversely affects calvaria and trabecular bone. alpha-Ketoglutarate (AKG) is a precursor of hydroxyproline - the most abundant amino acid in bone collagen. The purpose of this study was to investigate the effects of dietary AKG on Gx-induced osteopenia. Material and methods. Tw

The present study explores genetic engineering of the respiratory chain and the application of two different flexible osmium redox polymers to achieve efficient electric communication between the gram-positive organism Bacillus subtilis and an electrode. Poly(1-vinylimidazole)(12)-[Os-(4,4'-dimethyl-2,2'-bipyridyl)(2)Cl(2)](+/2+) (osmium redox polymer I) and poly(vinylpyridine)-[Os-(N,N'-methylate

Context processing refers to the operation of processing different types of context data and/or information using different kinds of operators. These operators are applied according to some conditions or constraints given in context queries. Existing context aware systems process context data in a centralized fashion to answer context queries and generate context information. However, this method

Background: An association between N-acetyltransferase 2 (NAT2) slow acetylation and bladder cancer has been consistently observed in epidemiologic studies. However, evidence has been mainly derived from case-control studies and was sparse from cohort studies. We evaluated the association between NAT2 slow acetylation and bladder cancer in a case-control study nested in the European Prospective In

Background: Supporting positive mental health development in adolescents is an important school health concern, but there is a need to investigate the suitability of the interventions used. Aim: To investigate the experiences of school health professionals in conducting a universal school-based program aimed at preventing depressive symptoms in adolescents. Methods: Twenty-two school health prof

In this paper the machinery of Hybrid Logic and the logic of public announcements are merged. In order to bring the two logics together properly the underlying hybrid logic has been changed such that nominals only partially denote states. The hybrid logic contains nominals, satisfaction operators, the downarrow binder as well as the global modality. Following this, an axiom system for the Hybrid P

Popular Abstract in Swedish Cellerna i kroppen är uppbyggda av fyra olika byggstenar: DNA, proteiner, fetter samt kolhydrater. Kolhydrater förknippas framförallt med energi och det pågår en intensiv debatt om kolhydraternas vara eller icke vara i vår kost. Kolhydraterna har dock också en helt annan funktion, en som är obestridligt oumbärlig för alla levande organismer. I denna roll förekommer de bGalectins are small soluble proteins defined by a conserved sequence motif that forms a defining β-galactoside binding site shared among galectins; adjacent binding sites give each galectin a unique fine specificity for a specific subset of galactose containing glycans. A wealth of data now suggests important roles of galectins in both cancer and inflammation. The aim of this project is to get a c

Popular Abstract in Swedish Tumörer i ben och mjukdelar är vanliga men utgör endast 1 % av alla maligna neoplasier. De elakartade tumörerna är ofta utmanande att diagnostisera pga deras relativt likartade morfologi samt att de är ovanliga. Således är all tilläggsinformation värdefull och genetiska analysmetoder kan bidra med information som är användbar och i vissa fall tom avgörande för diagnostiTumors of bone and soft tissue are common but only constitute 1 % of all malignant tumors. The malignant tumors are often difficult to diagnose due to their rarity and morphological resemblance between subtypes. This makes the diagnostic process challenging. Thus, there is a need for ancillary techniques, such as genetic analyses, not only for diagnostic purposes, but also for obtaining informatio

Using Low Energy Electron Diffraction (LEED) and Scanning Tunneling Microscopy (STM) we have investigated the structure of the GaP(111)B surface. We have previously studied the formation of Ga droplets on GaP(111)B above the maximum temperature for congruent evaporation. In the present work, we investigate the nanometer-sized pyramid-shaped crystallites that are found on the GaP(111)B surface and

Memories compete for retrieval when they are related to a common retrieval cue. Previous research has shown that retrieval of a target memory may lead to subsequent retrievalinduced forgetting (RIF) of currently irrelevant competing memories. In the present study, we investigated the time course of competitive semantic retrieval and examined the neurocognitive mechanisms underlying RIF. We contras

Global land acquisitions, often dubbed 'land grabbing' are increasingly becoming drivers of land change. We use the tools of network science to describe the connectivity of the global acquisition system. We find that 126 countries participate in this form of global land trade. Importers are concentrated in the Global North, the emerging economies of Asia, and the Middle East, while exporters are c

Geophysical survey of the Iron Age settlement at Uppåkra church in southwestern Scania revealed some odd anomalies at the highest point of the study area. The anomalies showed a rectangle surrounded by a circle. Excavation uncovered a rectangular pit with drystone walls and a stone-paved floor, surrounded by an annular ditch with a diameter of eight metres. Looters had severely damaged this appare

The uncertainty in eddy covariance (EC) flux measurements is assessed for CH4 and N2O using data measured at a dairy farm site in the Netherlands in 2006 and 2007. An overview is given of the contributing uncertainties and their magnitude. The relative and absolute uncertainty of a 30 min EC flux are estimated for CH4 and N2O using N = 2185 EC fluxes. The average absolute uncertainty and its stand