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Abstract in UndeterminedIn nineteenth-century Europe, the foundling hospital grew beyond its traditional purpose of mitigating the shame of unwed mothers by also permitting widows, widowers, and poor married couples to abandon their children there temporarily. In the Foundling Hospital of Madrid (fhm), this new short-term abandonment could be completely anonymous due to the implementation of a whe
Grafts of foetal ventral mesencephalon, used in cell replacement therapy for Parkinson's disease, are known to contain a mix of dopamine neuronal subtypes including the A9 neurons of the substantia nigra and the A10 neurons of the ventral tegmental area. However, the relative importance of these subtypes for functional repair of the brain affected by Parkinson's disease has not been studied thorou
Results from an experimental investigation of the phase behavior of an aqueous system of DNA from salmon testes and the protein lysozyme arc presented. At very low concentrations of either or both of the macromolecular components, wormlike assemblies with a width of the order of 10 nm are formed. There are strong indications that direct interactions between the protein units are instrumental both
Depression is the leading cause of disability worldwide and electroconvulsive therapy (ECT) is the most potent therapy. We investigated the clinical response and regional cerebral blood flow changes in depressed in patients treated with (ECT) in a repeated longitudinal study. Method: Forty-nine patients (21 men and 28 women) with a mean age 61 years underwent ECT. Forty-one patients grading improv
The lifetime risk for cardiovascular disease in a large cohort of childhood cancer survivors has not been fully assessed. In a retrospective population-based cohort study predicated on comprehensive national health registers, we identified a cohort of 32,308 one-year survivors of cancer diagnosed before the age of 20 in the five Nordic countries between the start of cancer registration in the 1940
Malarial infection is associated with complex immune and erythropoietic responses in the host. A quantitative understanding of these processes is essential to help inform malaria therapy and for the design of effective vaccines. In this study, we use a statistical model-fitting approach to investigate the immune and erythropoietic responses in Plasmodium chabaudi infections of mice. Three mouse ph
The use of supplemental oxygen in the setting of suspected acute myocardial infarction (AMI) is recommended in international treatment guidelines and established in prehospital and hospital clinical routine throughout the world. However, to date there is no conclusive evidence from adequately designed and powered trials supporting this practice. Existing data are conflicting and fail to clarify th
Background and Purpose: In this multicentre phase I-II trial we evaluated the feasibility and efficacy of capecitabine and oxaliplatin followed by the combination of these two drugs with radiotherapy in patients with locally advanced pancreatic or biliary tract cancer. Material and methods: Thirty-nine patients with inextirpable adenocarcinoma of the pancreas, gallbladder or extrahepatic bile duct
The major histocompatibility complex class II transactivator (CIITA) gene (16p13) has been reported to associate with susceptibility to multiple sclerosis, rheumatoid arthritis and myocardial infarction, recently also to celiac disease at genome-wide level. However, attempts to replicate association have been inconclusive. Previously, we have observed linkage to the CIITA region in Scandinavian ty
Atherosclerotic lesions are asymmetric focal thickenings of the intima of arteries that consist of lipids, various cell types and extracellular matrix (ECM). These lesions lead to vascular occlusion representing the most common cause of death in the Western world. The main cause of vascular occlusion is rupture of atheromatous lesions followed by thrombus formation. Fibronectin (FN) is one of the
Radiative interferences in the multi-parton shower is the building block of QCD jet physics in vacuum. The presence of a hot medium made of quarks and gluons is expected to alter this interference pattern. To study these effects, we derive the gluon emission spectrum off a color-correlated quark-antiquark pair (antenna) traversing a colored medium to first order in the medium density. The resultin
Environmental conditions and human activities play a significant role in structuring novel assemblages of native and non-native species. Ongoing and future climatic change may alter the performance of native and non-native species and their biotic interactions. In the northern hemisphere, expected climate changes include warmer temperatures and higher precipitation, the latter of which may increas
Objective To evaluate the influence of two ultra-low doses of oral continuous combined hormone therapy and placebo on metabolic parameters, and to assess safety endpoints and overall tolerability in healthy postmenopausal women. Design In a subpopulation of the Clinical study on Hormone dose Optimisation In Climacteric symptoms Evaluation (CHOICE) trial, lipids and parameters of glucose metabolism
Generic immunosuppressants may offer economic advantages, but their use is still controversial. At our centre, 55 heart-transplant patients were switched from CellCept(®) to Myfenax Teva(®) (MT) (n=51, 18% female, 8.1±6.6 years post-transplantation) and/or Prograf(®) to Tacrolimus Sandoz(®) (TS) (n=17, 41% female, 6.6±5.8 years post-transplantation).
The proteinuric actions of protamine sulfate (PS) have classically been, at least partly, attributed to alterations of the negatively charged glomerular endothelial glycocalyx (GC). To investigate whether the charge-selective properties of the glomerular filtration barrier (GFB) would be altered by PS we assessed the glomerular sieving of conventional, uncharged, polydispersed Ficoll (n-Ficoll) co
Ultrasound imaging of the heart is a non-invasive method widely used for different applications. One of them is to measure the blood volume in the left ventricle at different stages of the heart cycle. This demands a proper segmentation of the left ventricle and a (semi-) automated method would decrease intra-variability as well as workload. This paper presents a semi-automated segmentation method t
