Apolipoprotein E (APOE), one of the primary lipoproteins in the brain has three isoforms in humans - APOE2, APOE3, and APOE4. APOE4 is the most well-established risk factor increasing the pre-disposition for Alzheimer's disease. The presence of the APOE4 allele alone is shown to cause synaptic defects in neurons and recent studies have identified multiple pathways directly influenced by APOE4. How

This paper proposes Yggdrasil, a protocol for privacy-aware dual data deduplication in multi-client settings. Yggdrasil is designed to reduce cloud storage space while safeguarding the privacy of clients’ data. This is achieved by exploiting a ‘dual’ setting, where both the cloud and the clients store a fraction of the data. Yggdrasil combines two innovative techniques to achieve this goal. First,

BACKGROUND: α-synuclein (α-syn) aggregation contributes to the progression of multiple neurodegenerative diseases. We recently found that the isoform b of the co-chaperone DNAJB6 is a strong suppressor of a-syn aggregation in vivo and in vitro. However, nothing is known about the role of the endogenous isoform b of DNAJB6 (DNAJB6b) in health and disease, due to lack of specific antibodies.OBJECTIV

The research presented in this thesis is primarily focused on experimental investigations of laser-driven ion acceleration from solid targets via the target normal sheath acceleration mechanism. In particular, ways of optimizing the absorption of the laser pulse energy by free plasma electrons in the target, or modifying the shape of the accelerating electron sheath were addressed. The aim of this

Past research on the social determinants of colorectal cancer (CRC) has shown that lower socioeconomic status (SES) is associated with a higher risk of CRC. Similar to SES at the individual level, the neighbourhood social environment may partly affect the development of CRC. Although one important aspect of the neighbourhood social environment is social capital, no large-scale follow-up study has

Zinc (Zn) is an important trace element that is essential for optimal plant growth. Zinc-solubilising bacteria can release Zn from its insoluble compounds. We isolated and identified Zn-solubilising bacteria (ZnSB) from the rhizosphere, and semi-quantitively and quantitatively evaluated their ability to dissolve various Zn minerals (ZnO, ZnCO3 and Zn3(PO4)2). Out of 24 rhizosphere soil samples, 15

White quinoa grains were used as a source of novel beneficial microorganisms and as a matrix for development of a fermented plant-based drink. Studies on the quinoa grain microbiota were performed by applying spontaneous fermentation to allow isolation of autochthonous Lactiplantibacillus strains with potential to be used as starter cultures. The quinoa-based drink was fermented with the commercia

The patients’ burden of comorbidities is a cornerstone in risk assessment, clinical management and follow-up. The aim of this study was to evaluate if biomarkers associated with comorbidity burden can predict outcome in acute dyspnea patients. We included 774 patients with dyspnea admitted to an emergency department and measured 80 cardiovascular protein biomarkers in serum collected at admission.

In the mid-twentieth century, Sweden distinguished itself as one of the most organized and participatory democracies in the world, with high levels of voting turnout and party membership. But in the late nineteenth century the situation was much the opposite – Sweden had for Western Europe a low degree of suffrage, and low political participation. To explain the turnaround, this paper explores ext

Due to the aging population, hip fracture incidence has been increasing over the past decades. Measurements of bone mineral density with dual energy X-ray absorptiometry are the gold standard for hip fracture risk assessment, where patients with a low bone density have a high risk of fracture. However, many people that are not diagnosed to be at risk, still fracture their hip. Calculations of bone

BACKGROUND: There is a worldwide shift towards increased consumption of ultra-processed foods (UPF) with concurrent rising prevalence of obesity. We examined the relationship between the consumption of UPF and weight gain and risk of obesity.METHODS: This prospective cohort included 348 748 men and women aged 25-70 years. Participants were recruited between 1992 and 2000 from 9 European countries

We considered the phase coherence dynamics in a Two-Frequency and Two-Coupling (TFTC) model of coupled oscillators, where coupling strength and natural oscillator frequencies for individual oscillators may assume one of two values (positive/negative). The bimodal distributions for the coupling strengths and frequencies are either correlated or uncorrelated. To study how correlation affects phase c

BACKGROUND: Recent whole genome sequencing studies report that up to 6% of the childhood cancer population harbour a pathogenic variant. Identification of families with hereditary cancer may improve early detection of cancer as well as treatment outcome. AIMS: The overall aim of this thesis was to investigate familial cancer risk in relatives of children with cancer and assess the prevalence of pa

This article studies the difference in the government response to COVID-19 in Norway and Sweden drawing upon theories of agenda setting, crisis management and multi-level governance. Despite having virtually identical systems of government and, initially, facing similar infection threats, Sweden opted for far less strict countermeasures than Norway. While Norway’s government response was similar t