Leucocyte elastase in catalytic amounts was observed to rapidly cleave the Val-10-Gly-11 bond of the human cysteine-proteinase inhibitor cystatin C at neutral pH. The resulting modified inhibitor had size and amino acid composition consistent with a cystatin C molecule devoid of the N-terminal Ser-1-Val-10 decapeptide. Leucocyte-elastase-modified cystatin C had more than 240-fold lower affinity th

Measurements of on-shell ZZ production are described, using data from the DELPHI experiment at LEP in e(+)e(-) collisions at centre-of-mass energies between 183 and 209 GeV, corresponding to an integrated luminosity of about 665 pb(-1). Results obtained in each of the final states q (q) over barq (q) over bar, nu(ν) over barq (q) over bar, mu(+)mu(-) q (q) over bar, e(+)e(-) r(+)r(-) q (q) over ba

The fragile histidine triad (FHIT) gene, located within chromosome arm 3p, is a potential target for testicular tumorigenesis. In the present study, 62 primary testicular germ cell tumors were analyzed for allelic imbalance (AI) at 10 loci mapping to chromosome bands 3p14.1-21.1. Twenty-seven tumors (44%) showed AI at one or more 3p loci. The chromosome 3 copy number was evaluated by fluorescence

Popular Abstract in Swedish Det övergripande syftet med denna avhandling var utforska de allra äldstas upplevelser av delaktighet och självständighet med speciellt fokus på hemmet och närmsta omgivningen. Dagens debatt om åldrandet handlar mestadels om kvaliten i vård och omsorg, dess kostnader men också om bristande omsorg. Även boendefrågor debatteras, men då är det oftast bristen på s k särskiThe current trend in Sweden is to support older people to remain living in their own homes as long as possible. Older people spend much of their daily life within the home and neighbourhood environment. It is well known that participation and independence is important in experiencing well being in old age. Thus from a health-promotion perspective it is interesting to uncover aspects within the hom

This subject of this article is the discrepancy in 20th-century popular culture with regard to views on the Middle Ages. On the one hand, the medieval period has come to represent darkness, stupidity and, in the negative sense of the word, an old-fashioned attitude to life. On the other hand, the Middle Ages is often visualised as a positive antithesis to modernity, an age of heoric values, knight

There are substantial socioeconomic differences in cardiovascular morbidity and mortality in most western countries. Socioeconomic differences in cardiovascular risk factors (obesity/overweight, tobacco smoking, leisure time physical activity, dietary habits) are correspondingly large. The main aim of this study is to investigate the influence of psychosocial work conditions and social capital on

Feedbacks, or internal interactions, play a crucial role in the climate system. Negative feedback will reduce the impact of an external perturbation, a positive feedback will amplify the effect and could lead to an unstable system. Many of the feedbacks found in the climate system are positive; thus, for example, increasing CO2 levels will increase temperature, reduce the snow cover, increase the

Popular Abstract in Swedish Ordet "fängelse" ger mångfaldiga och motstridiga associationer; till höga murar och gallerförsedda fönster, till inspärrning, straff och farliga brottslingar men också till förtryck, utstötthet och trasiga människor. De svenska fängelserna växte fram under 1800-talet och var en del i en internationell trend. Fängelset framställdes som ett stort humanitärt och straffrättThe general aim of the thesis is to study 19th century Swedish prisons from the point of view of the surrounding discourse and also as a social system. The prison phenomenon grew out of the meeting between prisons as a discourse-produced norm system and the social practice consisting of the reality as experienced by the prisoners and the prison staff. The growth and development of the Swedish pris

The presence of a functional glpT gene in Haemophilus influenzae could be questioned, since there is only what appears to be a truncated glpT (HI0686, 143 nt in the 5'-end) available in the H. influenzae Rd genome database (Fleischmann et al. , 1995). For cloning of the glpT gene from H. influenzae type b strain Eagan, an isogenic glpT, rec-1 double mutant and a selective medium for detection of t

OBJECTIVE: To find out the prevalence of symptomatic non-palpable groin hernias in women under 40 years old with undiagnosed chronic groin pain. DESIGN: Retrospective analysis. SETTING: University hospital, Sweden. SUBJECTS: 116 women 14-39 years old (mean 27) with chronic undiagnosed groin pain who underwent herniography 1977-1994. INTERVENTIONS: Intraperitoneal injection of 80 ml iodine contrast

The relationships between characteristics of the ward atmosphere and treatment outcome in a psychiatric day-care unit were investigated. The treatment programme was based on occupational group therapy and included long-term mentally ill patients, equally distributed with regard to psychosis and non-psychosis diagnoses. The ward atmosphere was rated on the Community-Oriented Programs Environment Sc

Denna rapport sammanfattar resultat från tidigare genomförda utvärderingar inom byggnadsteknik, byggnadsmaterial, byggnadsfysik, energianvändning och luftkvalitet samt försöker värdera gjorda erfarenheter.

Activity quantification in nuclear medicine imaging is highly desirable, particularly for dosimetry and biodistribution studies of radiopharmaceuticals. Quantitative In-111 imaging is increasingly important with the current interest in therapy using Y-90 radiolabeled antibodies. One of the major problems in quantification is scatter in the images, which leads to degradation of image quality. The a

BACKGROUND: Although age is associated with increasing blood pressure, there is a substantial heterogeneity within a certain birth cohort. Whether increase in systolic and diastolic blood pressure is related to pulmonary function is largely unknown. OBJECTIVE: To study blood pressure elevation between 55 and 68 years of age in relation to vital capacity (VC) and forced expiratory volume (FEV1.0) a

Popular Abstract in Swedish Cellerna i blodet har en rad skilda funktioner, såsom att transportera syre, levra blodet vid behov eller att på olika sätt delta i vårt immunförsvar. Alla blodets celler härstammar från en s k stamcell som har förmåga att genom en rad förändringar mogna ut till vilken typ av cell som helst i blodsystemet. Leukemi är en sjukdom som drabbar blodet och som uppstår p g a aAcute myeloid leukemia (AML) is commonly associated with balanced chromosomal translocations. Characteristically, these translocations lead to the fusion of two unrelated genes, resulting in the expression of an aberrant fusion protein. t(8;21) is one of the most common translocations found in patients with AML. It results in the expression of the chimeric protein AML1-ETO. AML1 is a transcription