Background In placebo-controlled trials, reslizumab, an anti-IL-5 monoclonal antibody, significantly reduced asthma exacerbations and improved lung function and asthma control in patients with eosinophilic asthma. Objective This open-label extension study evaluated safety and efficacy of reslizumab for up to 24 months. Methods After participation in 1 of 3 placebo-controlled, phase III trials in m

Dynamic substructuring is often employed to reduce the size of numerical models for structural dynamic analysis. In this paper, we discuss how elastomeric vibration isolators can be modelled within the framework of dynamic substructuring in order to obtain accurate and efficient reduced order models. For several reasons, it is beneficial to divide a structure containing elastomeric isolators into

We test for the construct validity of the cognitive reflection test (CRT) by eliciting response times. We find that incorrect answers to the CRT are quicker than correct answers. At the individual level, we classify subjects into impulsive and reflective, depending on whether they choose the incorrect intuitive answer or the correct answer the majority of the time. We show that impulsive subjects

New combustion concepts are being investigated to develop cleaner engines. One of the most promising is partially premixed combustion. The mechanisms of this combustion mode and its impact on performance and emissions have been studied in the previous years. Nevertheless, little research has been done from the point of view of heat transfer. In particular, the influence of the injection strategy o

We present an optical system based on two toroidal mirrors in aWolter configuration to focus broadband extreme ultraviolet (XUV) radiation. Optimization of the focusing optics alignment is carried out with the aid of an XUV wavefront sensor. Back-propagation of the optimized wavefront to the focus yields a focal spot of 3.6 × 4.0 μm2 full width at half maximum, which is consistent with ray-tracing

This article develops and implements an agile management approach in higher education. Such an approach follows core practices, such as project plans. The project manager has to identify the agility drivers that represent changes and pressures; prioritize agility capabilities to take advantage of changes; identify agility providers to obtain agility capabilities; and make managerial choices to man

We present the first ever measurements of femtoscopic correlations between the KS 0 and K± particles. The analysis was performed on the data from Pb–Pb collisions at sNN=2.76 TeV measured by the ALICE experiment. The observed femtoscopic correlations are consistent with final-state interactions proceeding via the a0(980) resonance. The extracted kaon source radius and correlation strength paramete

Radial GaInP/AlGaInP nanowire array light-emitting diodes (LEDs) are promising candidates for novel high-efficiency solid state lighting due to their potentially large strain-free active emission volumes compared to planar LEDs. Moreover, by proper tuning of the diameter of the nanowires, the fraction of emitted light extracted can be significantly enhanced compared to that of planar LEDs. Reports

The increased demand for high purity nanoparticles (NPs) of defined geometry necessitates the continuous development of generation routes. One of the most promising physical techniques for producing metal, semiconductor or alloy NPs in the gas phase is spark discharge NP generation. The technique has a great potential for up-scaling without altering the particles. Despite the simplicity of the set

An increasing demand for energy-efficient buildings has led to an increasing focus on predicted energy performance once a building is in use. Many studies have identified a performance gap between predicted energy use and actual measured energy use once buildings are in the user phase. However, none of the identified studies normalise measured energy use for both internal and external deviating bo

Graphical user interface (GUI) development is generally complicated, time-consuming, and requires programming knowledge. In the context of the internet of things, this work focuses on producing an efficient development approach that also supports non-experts. We introduce a novel "inverted" development approach that does not require program code to be written - a step towards supporting end-user d

Aim: The aim was to evaluate the beneficial effect of early mitogen-activated protein kinase (MEK)1/2 inhibition administered at a clinical relevant time-point using the transient middle cerebral artery occlusion model and a dedicated rodent magnetic resonance imaging system (9.4T) to monitor cerebrovascular changes non-invasively for 2 weeks. Method: Transient middle cerebral artery occlusion was

Anthropological field studies of nongovernmental organizations (NGOs) in their unique cultural and political contexts.Cultures of Doing Good: Anthropologists and NGOs serves as a foundational text to advance a growing subfield of social science inquiry: the anthropology of nongovernmental organizations (NGOs). Thorough introductory chapters provide a short history of NGO anthropology, address how

Book chapter about the linking that is often made in popular media of creativity - frequently through examples from art history - and neurological disease. The chapter discusses the implications this linking may have for the dissemination of ideas about personality traits, artistic expression, neurological disease and neuroscience as a discipline.

The chapter investigates how one specific collaboration between a fashion conglomerate (Louis Vuitton) and a contemporary artist (Takashi Murakami) exemplifies a wider phenomenon of the ways in which brands curate artists to fit their own needs. Central to the chapter is the discussion about why and to what ends curation of art has become important for fashion brands in their branding efforts.