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Increased Plasma Soluble Interleukin-2 Receptor Alpha Levels in Patients With Long-Term Type 1 Diabetes With Vascular Complications Associated With IL2RA and PTPN2 Gene Polymorphisms

Type 1 diabetes (T1D) is largely considered an autoimmune disease leading to the destruction of insulin-producing pancreatic β cells. Further, patients with T1D have 3–4-fold increased risk of developing micro- and macrovascular complications. However, the contribution of immune-related factors contributing to these diabetes complications are poorly understood. Individuals with long-term T1D who d

Incidence and predictors of severe infections in ANCA-associated vasculitis in a population-based cohort – preliminary results

Background: Infectious complications in ANCA associated vasculitis (AAV) are a major cause of morbidity and mortality. The aim of this study was to determine the incidence rates, predictors and outcome of severe infections in AAV. Methods: We conducted a population-based cohort study in Southern Sweden with 326 incident cases of AAV diagnosed between 1997 and 2016. Diagnosis of vasculitis was conf

Delegation Decisions in Finance

We run an online experiment with finance professionals and subjects from the general population (clients) to examine drivers and implications of clients' delegation decisions. We find that clients favor delegation to investment algorithms, followed by delegation to finance professionals with aligned incentives and lastly to those with fixed incentives. We also show that trust in investment algorit

Whose Cultural Memory? : Disruptive Tactics by the Creative Collectives in George Town, Malaysia

This chapter examines everyday lived experiences of individuals and groups from various creative collectives in George Town, Malaysia. The process of these articulations is explored through their everyday dwelling in this city, especially in responding to the so-called official narrative of creative city within heritage context. This chapter aims to understand how the everyday tactics of creative

The Call of *Yaqtulu : The Central Semitic Imperfective, Nominalisation and Verbal Semantics in Cyclical Flux

The article discusses the discrepancy between the *yaqattal and *yaqtulu imperfectives (the former known from East Semitic, Ethiosemitic and Modern South Arabian and the latter from Central Semitic). It argues that original nominalised phrases such as “he is a killer” came about based on an earlier “he is one who killed”, and that these were subsequently reinterpreted as imperfectives. A compariso

Soil carbon insures arable crop production against increasing adverse weather due to climate change

Intensification of arable crop production degrades soil health and production potential through loss of soil organic carbon. This, potentially, reduces agriculture's resilience to climate change and thus food security. Furthermore, the expected increase in frequency of adverse and extreme weather events due to climate change are likely to affect crop yields differently, depending on when in the gr

Diet and Lifestyle as Risk Factors for Carotid Artery Disease : A Prospective Cohort Study

Background: Stroke is one of the leading causes of death, and out of all stroke cases, 10-15% originate from a previously asymptomatic stenosis in the internal carotid artery. Aims: The aim of the study was to investigate whether dietary and lifestyle habits were associated with future risk of incident carotid artery disease (CAD). Methods: Baseline examinations on middle-aged individuals (n = 30,

Towards Celiac-safe foods : Decreasing the affinity of transglutaminase 2 for gliadin by addition of ascorbyl palmitate and ZnCl2 as detoxifiers

Initiation of celiac disease is triggered in the gastrointestinal tract by transglutaminase 2 (TG2) assisted deamidation of gluten peptides. Deamidation is a side-reaction to transamidation and occurs if primary amines are absent. In contrast to deamidation, transamidation does not trigger an immune response. The aim of the study was to identify a suitable food additive that interacts with TG2 bin

Institutions, Events and Theory: A Comparison of the Monetary Policy Reforms of 1844/45 in England and Sweden.

The paper analyses the role of ideas, past experience and crises in the process leading to theoretical and political disputes and the changes of monetary and banking policy in Sweden in 1844/45. It also analyses the role of institutional settings and types of actors involved in the decision-making process. A comparative approach is deployed. Policy changes at the time in the poor and peripheral Sw

There is logic in logit - Including wear rate in Colding's tool wear model

Modelling of tool wear in metal cutting processes has been the foundation of the field since the famous Taylor's tool life model. Tool wear models have been developed for planning machining operations and calculating production costs. Most wear models do not include wear rate in the model but rather just the final wear at end of tool life, i.e. the limiting wear. This is a major disadvantage of Ta