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The BACE1 gene encodes the beta-site APP-cleaving enzyme 1 and has been associated with Alzheimer's disease (AD). BACE1 is the most important beta-secretase responsible for the generation of Alzheimer-associated amyloid beta-proteins (A beta) and may play a role in the amyloidogenic process in AD. We hypothesized that BACE1 gene variants might influence BACE1 activity or other markers for APP meta

P>Photoreceptor degeneration is the hallmark of a group of inherited blinding diseases collectively termed retinitis pigmentosa (RP); a major cause of blindness in humans. RP is at present untreatable and the underlying neurodegenerative mechanisms are largely unknown, even though the genetic causes are often established. The activation of calpain-type proteases may play an important role in cell

There is growing interest in the use of arbuscular mycorrhizal fungi (AMF) for ecological restoration. Numerous commercial AMF products are now available and are often used in preference to collecting indigenous AMF in treating restoration plants. Commercial AMF products are typically based on AMF strains exotic to the plant species and locations where they are used. We treated rooted cuttings of

This article analyses the path dependence of European copyright. It shows how copyright is legally constructed, is harmonised through international treaties and European regulatory efforts in terms of InfoSoc Directive and the IPRED, and is also affected by the Data Retention Directive and the Telecommunications Reform package. Furthermore, the “secretly” negotiated ACTA agreement is discussed as

The present study deals with Elastic Flow Rerouting (EFR)-an original traffic restoration strategy for protecting traffic flows in communication networks (including wireless networks) against multiple link failures. EFR aims at alleviating the trade-off between practicability of traffic restoration and the cost of network resources observed in existing networking solutions. We present an extension

Streptococcus pneumoniae (the pneumococcus) is a common colonizer of the human nasopharynx. Despite a low rate of invasive disease, the high prevalence of colonization results in millions of infections and over one million deaths per year, mostly in individuals under the age of 5 and the elderly. Colonizing pneumococci form well-organized biofilm communities in the nasopharyngeal environment, but

Host resistance against parasites depends on three aspects: the ability to prevent, control and clear infections. In vertebrates the immune system consists of innate and adaptive immunity. Innate immunity is particularly important for preventing infection and eradicating established infections at an early stage while adaptive immunity is slow, but powerful, and essential for controlling infection

Purpose This paper investigates contracts of the intermodal transport market and the incentives they create for a modal shift and thus the financial and environmental efficiency of freight transport. Design/methodology/approach The research used a mixed-methods approach where qualitative case interviews and quantitative modeling was combined. Two cases of contractual relationships between a serv

The paper reports on the modeling and respective experimental validation for the formation of the machined subsurface layer in turning with nose-radiused and round tools. An experimental work on the mechanisms of work-hardening of the machined surface and related wear of the cutting tools was conducted for high-speed turning of aged Inconel 718 with whisker-reinforced alumina tools. The model show

Holmqvist, G. & Lundqvist Persson, C. (2011). Is there evidence for the use of art therapy in treatment of psychosomatic disorders, eating disorders and crisis? A comparative study of two different systems for evaluation. Scandinavian Journal of Psychology. As with any type of treatment the requirement for evidence based practice (EBP) has also affected art therapy (AT) when used as an interve

The aim of this study is to provide a survey of systematic reviews that have evaluated the effects of psychosocial interventions for adult people with intellectual disabilities and/or an autistic syndrome with concurrent mental health problems. Reviews for inclusion were identified through searches of 10 electronic databases. The authors found that 3 out of 126 published reviews met the inclusion