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Introduction: Neuromelanin containing cell loss, neuroinflammation and synaptic dysfunction are believed to contribute to Parkinson's disease (PD) pathogenesis. [18F]DOPA PET reflects dopamine storage capacity in the putamen, while midbrain off-target retention of [18F]RO948 is hypothesized to reflect neuromelanin. Objectives: To investigate associations between disease duration, cerebrospinal flu
Determining the appropriate duration for traffic conflict observation remains a critical yet unresolved challenge in road safety analysis. Existing approaches lack a quantitative approach to determine adequate sample sizes for general conflict-based applications. This study addresses this gap by proposing an extreme value theory based framework to determine appropriate observation durations, based
This study analyzed daily temperature data from 114 meteorological stations in the Qinling-Daba Mountains from 1980 to 2017, focusing on core zones (CE I ≥ 2274 m, CE II 1321–2274 m) and peripheral zones (PE I 668–1321 m, PE II < 668 m). Using 15 extreme temperature indices computed with RClimDex, we assessed the spatiotemporal patterns, trends, and response to climate warming of extreme temperatu
Cumulate xenoliths from beach boulders in Anaga, Tenerife were analyzed through optical microscopy, scanning electron microscopy (SEM), both EDS and EBSD, and barometric modelling to study the magmatic evolution and volcanic plumbing system of the Anaga massif. Petrographic results indicate crystallization from hydrous basaltic magmas at equilibrium. This was further supported with chemical analy
OBJECTIVE: Screening for abdominal aortic aneurysm (AAA) using ultrasound in men reduces aneurysm-related mortality. Ambulatory screening and surveillance procedures facilitated by point-of-care ultrasound (POCUS) may improve adherence to screening programs. This proof-of-concept study evaluated whether infrarenal aortic diameter (IAD) can be accurately and interchangeably measured using handheld
PURPOSE: Groin hernia repair is a common procedure in general surgery, and is taught to and performed by surgeons early in their training. The aim of this observational study was to compare hernia repair performance and results of surgical trainees with those of a specialized surgeon, to identify what factors may influence short and long-term outcome, and areas for improvement in surgical training
A central assumption in neuroscience is that learning mechanisms are conserved across species. Eyeblink conditioning, a cornerstone paradigm for studying associative learning and cerebellar function, has been widely used in humans and animal models alike. Yet direct cross-species comparisons remain rare. In this systematic review, we analyzed 484 eyeblink conditioning experiments reported in 271 s
BACKGROUND: Drug-coated devices are frequently used in coronary and peripheral interventions, but their effect on amputation risk in peripheral artery disease is unclear. We assessed whether drug-coated devices affect the rate of above-ankle amputation in patients with chronic limb-threatening ischaemia undergoing infrainguinal endovascular revascularisation.METHODS: The Swedish Drug-Elution Trial
Objective: The aim of this study is to describe how the use of diagnostic imagingfor prostate cancer (PCa) has evolved over time and to determine whether thereare any differences in access to diagnostic imaging, type of cancers detected, andmortality based on the education level of patients.Methods: 11,063 men were recruited between 1991 and 1996 and thenprospectively followed until 2020. All new
BACKGROUND: Drug-coated devices are widely used to reduce restenosis after lower limb revascularisation in patients with peripheral artery disease, but their effect on patient-centred outcomes remains unclear. We assessed the effect of paclitaxel-coated devices on clinically important outcomes in patients with intermittent claudication undergoing infrainguinal endovascular revascularisation.METHOD
OBJECTIVE: Childhood obesity may impact the risk of islet autoimmunity (IA). The trajectory of BMI through childhood resembles the early peak incidence of first-appearing autoantibodies against insulin (IAA-first) but not GAD65 (GADA-first). We studied whether a child's BMI can impact the age-related risk of first-appearing IA phenotypes.RESEARCH DESIGN AND METHODS: We identified 7,724 children at
Bakgrund: Neuropsykiatriska funktionsnedsättningar uppstår oftast tidigt i barndomen, vilket gör tidig identifiering viktig för att stödja hälsosam utveckling. Det saknas ett bredare screeninginstrument för neuropsykiatrisk funktionsnedsättning för barn under två och ett halvt år. SÖK-Observations instrumentet utvecklades för att identifiera atypisk utveckling och autism hos barn vid 8-månaders hä
Background: Energy hardship can be broadly understood as a situation in which individuals or households are unable to afford basic energy services necessary for sustaining their wellbeing. Despite conceptual challenges and overlaps with similar narratives (e.g., fuel poverty), the literature on energy hardship continues to expand. It represents a critical intersection with sustainable energy syste
Hydrogen energy technologies are forecasted to play a critical supporting role in global decarbonisation efforts, as reflected by the growth of national hydrogen energy strategies in recent years. Notably, the UK government published its Hydrogen Strategy in August 2021 to support decarbonisation targets and energy security ambitions. While establishing techno-economic feasibility for hydrogen ene
Increasing the stability of energy management systems is crucial, especially when facing extreme weather events. A common approach to prevent sudden oscillations is the implementation of predictive models; however, this often requires more complex models and greater computational power. In this work, weather forecasts are integrated into an approach based on Adaptive Reinforcement Learning for Ene
Aims T cells are present in atrial tissue from atrial fibrillation (AF) patients. However, prospective studies of T cells and AF development are few. The current aim was to investigate if T-cell subsets are associated with the risk of developing AF. Methods and results T-cell subsets, measured by flow cytometry of cryopreserved mononuclear leucocytes isolated from blood at baseline, were analysed
Climate change can raise average temperatures and humidity and induce more frequent and stronger extreme weather events. This intensifies the need for studies on indoor climate and energy use in livestock buildings as it will affect animal welfare and farmers’ economy in terms of production, energy demand and needed investments. The aim of this review was to identify knowledge gaps and the need fo
A search for the exclusive hadronic decays Formula Presented, Formula Presented, and Formula Presented is performed using up to Formula Presented of proton-proton collisions recorded with the ATLAS detector at a center-of-mass energy of Formula Presented. If observed, these rare processes would provide a unique test bench for the quantum chromodynamics factorization formalism used to calculate cro
Objectives: High quality nutrition and medical nutrition therapy in long-term care (LTC) settings are essential to overcome malnutrition and ensure a better quality of life. Heterogenous and often insufficient regulations contribute to a disparity in nutritional practices across Europe. The aim of the study was to gather information on nutrition-related regulations and practices, as well as establ
