Heart failure (HF) and subarachnoid hemorrhage (SAH) chronically reduce cerebral perfusion, which negatively affects clinical outcome. This work demonstrates a strong relationship between cerebral artery cystic fibrosis transmembrane conductance regulator (CFTR) expression and altered cerebrovascular reactivity in HF and SAH. In HF and SAH, CFTR corrector compounds (C18 or lumacaftor) normalize pa

The measurement of the production of prompt D0, D+, D*+, and DS+ mesons in proton–lead (p–Pb) collisions at the centre-of-mass energy per nucleon pair of sNN = 5.02 TeV, with an integrated luminosity of 292 ± 11 μb−1, are reported. Differential production cross sections are measured at mid-rapidity (−0.96 < ycms< 0.04) as a function of transverse momentum (pT) in the intervals 0 < pT< 36 GeV/c for

We demonstrate the generation and in-situ measurement of the electric field and CEP of intense near-single-cycle laser pulses using the new optical technique of CEP dispersion-scan.

We study the spectral phase introduced by parametric amplification and how high extraction efficiency of energy leads to deterioration of the phase. Avoiding this regime, and using a pulse shaper, we achieve high-contrast ultrashort pulses.

Aim: To validate a deep-learning (DL) algorithm for automated quantification of prostate cancer on positron emission tomography/computed tomography (PET/CT) and explore the potential of PET/CT measurements as prognostic biomarkers. Material and methods: Training of the DL-algorithm regarding prostate volume was performed on manually segmented CT images in 100 patients. Validation of the DL-algorit

Background: About two-thirds of patients with Alzheimer’s disease (AD) are women, mostly because of their longer life-span and the higher prevalence of AD among older persons. A more-pronounced association between AD pathology and dementia (faster brain atrophy) and more-rapid cognitive decline have been reported in women. The AD prognosis might be affected by, e.g., size of cerebral hemispheres,

The gender-neutral third-person pronoun singular hen was recently introduced in Swedish as a complement to she (hon) and he (han). The initiative to add hen initially received strong criticism. In the present study, we analyzed 208 arguments from 168 participants with critical attitudes toward hen. We used Blaubergs’ (1980) and Parks and Roberton’s (1998) taxonomies of critical arguments against p

Glycerol levels in adipocytes depend on the lipolysis, the hydrolysis of triglycerides into glycerol and free fatty acids, and the efflux of glycerol across the plasma membrane through glycerol channels. The aims of this work were to investigate how glycerol levels are regulated on a molecular level by PLIN1, a major lipid droplet-associated protein and a key regulator of the lipolysis by scaffold

INTRODUCTION: In the ECG, significant ST elevation or depression according to specific amplitude criteria can be indicative of acute coronary syndrome (ACS). Guidelines state that the ST amplitude should be measured at the J point, but data to support that this is the optimal measuring point for ACS detection is lacking. We evaluated the impact of different measuring points for ST deviation on the

A constitutive model for aluminum alloys under hot working conditions is proposed. The elastic-viscoplastic model is implemented in a finite strain continuum mechanical frame- work. The model accounts for the interplay between dynamic recovery and recrystalliza tion during hot working of aluminum alloys and central aspects of microstructure evolution such as grain/subgrain size and dislocation denA constitutive model for aluminum alloys under hot working conditions is proposed. The elastic-viscoplastic model is implemented in a finite strain continuum mechanical framework. The model accounts for the interplay between dynamic recovery and recrystallization during hot working of aluminum alloys and central aspects of microstructure evolution such as grain/subgrain size and dislocation densit

Behavioral and electroencephalography (EEG) data were analyzed from 30 participants performing a demanding, attention-capturing task in which they had to detect an occasional decrement of luminance of small discs. Crucially, numerous white segments in the background were presented either in random orientations or configuring a contour shape of a square or a diamond. The participants' awareness of