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Glycolipid-lectin-driven endocytosis controls the formation of clathrin-independent carriers and the internalization of various cargos such as β1 integrin. Whether this process is regulated in a dynamic manner remained unexplored. Here we demonstrate that, within minutes, the epidermal growth factor triggers the galectin-driven endocytosis of cell-surface glycoproteins, such as integrins, that are
Importance: Better understanding of patients' attitudes toward deprescribing specific medications will inform future deprescribing interventions. Objective: To investigate older adults' attitudes toward deprescribing by investigating which medications they would like to have deprescribed, the reasons why, and patient factors associated with interest in deprescribing. Design, Setting, and Participa
In this paper, we present a summary of fractal calculus and propose the use of Lagrange multipliers for both fractal calculus and fractal variational calculus with constraints. We examine the application of these methods across various branches of physics. By employing fractal variational calculus with constraints, we derive fundamental equations such as the fractal mechanical wave equation, the f
The acute respiratory distress syndrome (ARDS) inflammatory environment alters mesenchymal stromal cell (MSC) gene and protein expression but effects on microRNA (miRNA) content of MSC-extracellular vesicle (EVs) remain unknown. To assess this, sequencing analysis of EV-miRNAs prepared from human bone marrow-derived MSCs (hMSCs) exposed ex vivo to bronchoalveolar lavage fluid (BALF) from ARDS pati
Developing an efficient code for large, multiscale astrophysical simulations is crucial in preparing for the upcoming era of exascale computing. RAMSES is an astrophysical simulation code that employs parallel processing based on the message-passing interface (MPI). However, it has limitations in computational and memory efficiency when using a large number of CPU cores. The problem stems from ine
Purpose: Myocardial infarctions (MIs) can occur in underlying obstructive coronary artery disease (MI-CAD) or in non-obstructive coronary arteries (MINOCA). The primary objectives of the study were to investigate the prevalence of MI-CAD and MINOCA in people with CAL, and to explore if CAL is an independent risk factor for MI-CAD and MINOCA. Secondary objectives were to explore these research ques
Linear quadratic (LQ) control optimizes a quadratic cost function while following a linear model. It is commercially available in the process industry but often not labeled as such and infrequently used. Froth flotation is a process in the minerals industry that extracts precious metals from a slurry of finely ground rock in consecutive tanks called cells. Flotation cells are often arranged in two
This study examines whether individual propensity to commit crime and family environment interact in their association with child-to-parent violence (CPV). We assume that individual propensity will be more strongly associated with CPV among those adolescents who are less attached to and controlled by their parents. The study has a cross-sectional design of 4,930 adolescents (age 16 years on averag
Studies show that child-to-parent violence (CPV) occurs in many families, but the impact of ethnicity on CPV is largely unknown. This cross-sectional study examines whether there are differences in CPV between ethnic Swedish adolescents and adolescents with a background in Muslim countries, both first and second generation. The study is based on a stratified sample of 4222 adolescents and young ad
Introduction In type 2 diabetes (T2D), beta cell failure is often associated with islet inflammation driven by the innate immune response, with macrophages playing a significant role. However, the composition and phenotype of lymphoid immune cells in the islets of individuals with T2D have not been extensively studied. This study aims to characterize and compare the presence, phenotype, and freque
Background: The growing challenges of population aging create a pressing need for specialized geriatric medicine services to effectively address the complex health needs of older adults and influence supportive healthcare policies. Older patients may present clinical complexity with multimorbidity, disability, and/or frailty, necessitating a shift from the traditional organ-oriented clinical appro
Summary: Screening initiatives for osteoporosis must facilitate treatment of those at elevated fracture risk. In a randomized controlled trial of 24,229 women, those in the screening group with FRAX ≥ 15% were invited for DXA with AOM treatment offered as per national guidelines. Treatment initiation in the following year was 9.5 times higher compared with controls. Purpose: To determine if screen
Cyber-Physical Systems (CPS) are integral to critical infrastructure, but their interconnected nature exposes them to sophisticated cyber threats. Traditional security mechanisms primarily focus on detecting direct manipulations of control signals or sensor data, leaving them vulnerable to more subtle attack vectors. This paper introduces a novel optimisation framework for modelling and executing Cyber-Physical Systems (CPS) are integral to critical infrastructure, but their interconnected nature exposes them to sophisticated cyber threats. Traditional security mechanisms primarily focus on detecting direct manipulations of control signals or sensor data, leaving them vulnerable to more subtle attack vectors. This paper introduces a novel optimisation framework for modelling and executing
Background and purpose — In complex primary total knee arthroplasty (TKA), constrained condylar knee (CCK) or rotating hinge knee (RHK) designs may be required to provide stability or address bony deficiencies. We analyzed trends in incidence of these designs in primary TKA and evaluated the mid-to long-term survivorship of CCK and RHK in 4 Nordic countries. Methods — From 2000 to 2017, 5,134 CCK
Evolutionary changes in geographic distribution and larval host plants may promote the rapid diversification of montane insects, but this scenario has been rarely investigated. We studied the rapid radiation of the butterfly genus Colias, which has diversified in mountain ecosystems in Eurasia, Africa, and the Americas. Based on a data set of 150 nuclear protein-coding genetic loci and mitochondri
Context. The peculiar Galactic globular cluster ω Centauri (NGC 5139) has drawn attention for its unique features, such as an unusually high stellar mass compared to other Galactic globular clusters and a broad distribution of chemical elements. These features have led to the hypothesis that ω Centauri might be the nuclear remnant of an ancient dwarf galaxy accreted by the Milky Way, potentially b
High-speed vertical III–V nanowire transistors utilize their channel material for high frequency and low noise performance. A device layout revision to optimize gate resistance, in a trade-off to gate-source capacitance, is presented. A two-step redesign of the established device layout is proposed. First step is demonstrated with fabricated structures. The second step predicts the design transiti
