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Selective vulnerability in neurodegeneration: insights from clinical variants of Alzheimer's disease.

Selective vulnerability in the nervous system refers to the fact that subpopulations of neurons in different brain systems may be more or less prone to abnormal function or death in response to specific types of pathological states or injury. The concept has been used extensively as a potential way of explaining differences in degeneration patterns and the clinical presentation of different neurod

Third trimester assessment of the uterine scar in women with prior caesarean: what is the evidence?

The increasing rate of caesarean delivery is a worldwide concern. A major contributor to this evolution has been a concomitantly decline in vaginal birth after caesarean, because of the risk of intrapartum uterine rupture, which is a rare but potentially catastrophic complication of a trial of labour after caesarean (TOLAC). On the other hand, elective repeat caesarean is associated with surgical

Effects of Walking Speed and Results of Timed Get-Up-and-Go Tests on Quality of Life and Social Participation in Elderly Individuals With a History of Osteoporosis-Related Fractures.

OBJECTIVE: To investigate the relationships between physical performance, quality of life (QoL), and social participation among elderly men and women with a history of osteoporosis-related fractures. METHOD: The study was a population-based cross-sectional study including 155 participants aged 60 to 93 years from the Swedish longitudinal investigation, "Good Aging in Skåne." The participants had s

Volume analysis of true and false lumens in acute complicated type B aortic dissections after thoracic endovascular aortic repair with stent grafts alone or with a composite device design.

This study compared the 12-month evolution of the aortic volume in patients who underwent thoracic endovascular aortic repair (TEVAR) with stent grafts alone or a composite device (Zenith TX2 stent graft and Zenith Dissection stent; Cook Medical, Bloomington, Ind) for acute (≤2 weeks from onset) complicated type B aortic dissection.

Language Acquisition and Use in Multilingual Contexts

This volume brings together current linguistic research in a range of pre¬dominantly multilingual contexts. The authors draw on data from different languages and speech communities around the world, and together the chapters offer a broad picture of language acquisition, development and use – among both children and adults. While this is a valuable undertaking in its own right, the main reason for

Update on Clinical Trials in Dry Age-related Macular Degeneration.

This review article summarizes the most recent clinical trials for dry age-related macular degeneration (AMD), the most common cause of vision loss in the elderly in developed countries. A literature search through websites https://www.pubmed.org and https://www.clinicaltrials.gov/, both accessed no later than November 04, 2015, was performed. We identified three Phase III clinical trials that wer

High-titer GAD65 autoantibodies detected in adult diabetes patients using a high efficiency expression vector and cold GAD65 displacement.

Adult type 2 diabetes patients with GAD65 autoantibodies (GADA) are known as latent autoimmune diabetes in adults (LADA). It has been suggested that GADA in LADA patients preferentially bind to the N-terminal end of GAD65. Using the N-terminal end extension of (35)S-GAD65 generated by the pEx9 plasmid, we tested the hypothesis that GADA in LADA patients preferentially react with (35)S-GAD65 from t

Breast tomosynthesis and digital mammography: a comparison of diagnostic accuracy.

Objective: Our aim was to compare the ability of radiologists to detect breast cancers using one-view breast tomosynthesis (BT) and two-view digital mammography (DM) in an enriched population of abnormal (diseased) patients and benign and/or normal (healthy) patients. Methods: All participants gave informed consent. The BT and DM examinations were performed with about the same average glandular