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Randanteckningar om svensk mediepolitik 1920–1970 : Ur temamodellering av 11 000 riksdagsprotokoll

In an explorative manner, this article uses a data-driven digital history set-up to focus on how the Swedish Riksdag, its political parties and parliament members discussed media issues. By distant reading and topic modeling a dataset of more than 11,000 parliamentary minutes – approximately 400 million characters – the article gives a new perspective of Swedish media history in general and nation

Monoglyceride Lipase Deficiency Is Associated with Altered Thrombogenesis in Mice

Monoglyceride lipase (MGL) hydrolyzes monoacylglycerols (MG) to glycerol and one fatty acid. Among the various MG species, MGL also degrades 2-arachidonoylglycerol, the most abundant endocannabinoid and potent activator of the cannabinoid receptors 1 and 2. We investigated the consequences of MGL deficiency on platelet function using systemic (Mgl-/-) and platelet-specific Mgl-deficient (platMgl-/

Ignorance and the regulation of artificial intelligence

Much has been written about the risks posed by artificial intelligence (AI). This article is interested not only in what is known about these risks, but what remains unknown and how that unknowing is and should be approached. By reviewing and expanding on the scientific literature, it explores how social knowledge contributes to the understanding of AI and its regulatory challenges. The analysis i

Pluralism, paralysis, practice: making environmental knowledge usable

In recent years, the global environmental science-policy interface has come to include a greater variety of knowledge. Social scientists have joined natural scientists at the policy table, and Indigenous and local knowledge is being taken ever more seriously. But this pluralisation raises political, normative, and epistemic challenges for environmental expert organisations, including with respect

Treatment of Mouse Infants with Amoxicillin, but Not the Human Milk-Derived Antimicrobial HAMLET, Impairs Lung Th17 Responses

Emerging evidence suggests differential effects of therapeutic antibiotics on infant T cell responses to pathogens. In this study, we explored the impact of the treatment of mouse infants with amoxicillin and the human milk-derived antimicrobial HAMLET (human alpha-lactalbumin made lethal to tumor cells) on T cell responses to Streptococcus pneumoniae. Lung cells and splenocytes were isolated fro

Contraction of human brain vascular pericytes in response to islet amyloid polypeptide is reversed by pramlintide

The islet amyloid polypeptide (IAPP), a pancreas-produced peptide, has beneficial functions in its monomeric form. However, IAPP aggregates, related to type 2 diabetes mellitus (T2DM), are toxic not only for the pancreas, but also for the brain. In the latter, IAPP is often found in vessels, where it is highly toxic for pericytes, mural cells that have contractile properties and regulate capillary

What is significant for engagement in cycling and walking in South Korea? Applying value-belief-norm theory

The value-belief-norm (VBN) theory has been widely used to describe pro-sustainability behavior. Despite being used to examine issues of sustainable and public transport behavior, research using the VBN has largely overlooked the pro-environmental behavior of cyclists and walkers, which is extremely significant given the role of active transport in environmental and human health. Therefore, this s

Impact of trigeminal and/or olfactory nerve stimulation on measures of inspiratory neural drive : Implications for breathlessness

The perception of breathlessness is mechanistically linked to the awareness of increased inspiratory neural drive (IND). Stimulation of upper airway cold receptors on the trigeminal nerve (TGN) with TGN agonists such as menthol or cool air to the face/nose has been hypothesized to reduce breathlessness by decreasing IND. The aim of this systematic scoping review was to identify and summarize the r

A Switched Array Sounder for Dynamic Millimeter-Wave Channel Characterization: Design, Implementation and Measurements

A prerequisite for the design and evaluation of wireless systems is the understanding of propagation channels. While abundant propagation knowledge exists for bands below 6 GHz, the same is not true for millimeter-wave frequencies. In this paper, we present the design, implementation and measurement-based verification of a re-configurable 27.5-29.5 GHz channel sounder. Based on the switched array

Temperature measurements in heated gases and flames using carbon monoxide femtosecond two-photon laser-induced fluorescence

Nonintrusive temperature measurement is crucial in combustion research. Here, we propose a thermometric technique based on femtosecond two-photon laser-induced fluorescence of carbon monoxide (CO-fs-TPLIF). A femtosecond laser with a wavelength of 230 nm was used as an excitation source. Owing to its intrinsic broad bandwidth, dual vibrational bands of the B1Σ+ ← X1Σ+ transition of CO can be simul

For or against 'the business of benchmarking'?

This short response does two things. First, it argues that urban benchmarks have specific and structural limits not identified in the principal essay in this intervention, which curtail the kinds of constructive and critical work such benchmarks might be expected to perform. ISO 37120 is discussed as an example. Second, it proposes a pluralistic approach to engagement and offers six suggestions fo

From the Boltzmann equation with non-local correlations to a standard non-linear Fokker-Planck equation

In this work, we study the formal connections between the non-linear Fokker-Planck Equation associated with the non-additive entropy and the Boltzmann Equation with the non-additive correlation functional. The collisional term following the q-algebra is adopted. In the derivation of the non-additive Fokker-Planck Equation, two constraints are imposed on the final result: i) that the entropic index

Environmental expertise for social transformation: roles and responsibilities for social science

What role should social science play in the work for transforming society towards sustainability? The background for this question is that despite massive investments in environmental research and the accumulation of data on the human impact on the environment, action remains insufficient. The severity of the current situation has led to the conclusion that moderate change is not enough; there is

Generation and properties of organic colloids extracted by water from the organic horizon of a boreal forest soil

Organic colloids are an important part of dissolved organic matter (DOM) yet many of their properties remain elusive. The main aims of this study were to assess how the colloidal properties of DOM extracted with water from an organic boreal soil horizon varied with the extraction protocol, and thereby provide insight into the nature of the DOM colloids and develop a mechanistic understanding of ho