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Novel selective orally active CRTH2 antagonists for allergic inflammation developed from in silico derived hits

Hits from an in silico derived focused library for CRTH2 were transformed into highly selective antagonists with favorable ADME properties. Oral administration of 4-bromo-2-(1-phenyl-1H-pyrazole-4-carbonyl)phenoxyacetic acid (19) inhibited peribronchial eosinophilia and mucus cell hyperplasia in a mouse model of allergic asthma, supporting the therapeutic potential of this novel compound class. In

Memory distorions resulting from a choice blindness task

Using a choice blindness paradigm, it is possible to switch decisions and outcomes in simple choice tasks. Such switches have been found to carry over into later choices, hypothesized to be mediated by beliefs about earlier decisions. Here we investigated participants’ memories for stimuli in a simple choice blindness task involving preferential choices between pairs of faces. We probed participan

The memorability of names and the divergent effects of prior experience

Pre-experimental familiarity can have paradoxical effects on episodic memory. Knowledge of the stimulus domain usually enhances memory, but word frequency - a presumed correlate of prior experience - is negatively related to recognition accuracy. The present study examined episodic recognition of names and its relation to two measures of pre-experimental knowledge, name frequency, and fame. Freque

Dataflow programs analysis and optimization using model predictive control techniques: An example of bounded buffer scheduling

This paper presents a new approach to buffer dimensioning for dynamic dataflow implementations. A novel transformation applied to the execution trace graph of a dataflow program is introduced in order to generate an event driven system. It is shown how model predictive control theory techniques can be applied to such a system to analyse the execution space of a dataflow program and to define and t

An Analytic Solution to Fixed-Time Point-to-Point Trajectory Planning

We derive an analytic solution to the problem of fixed-time trajectory generation with a quadratic cost function under velocity and acceleration constraints. This problem has a wide range of applications within motion planning. The advantage of the analytic solution compared to numerical optimization of the discretized problem is the unlimited resolution of the solution and the efficiency of the c

Kyrkohistorisk årsskrift 2006

The year-book Kyrkohistorisk Årsskrift 2006 contains nine articles on Ecclesiastical History from the twelfth to the twentieth century, as well as several book reviews.