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Dietary intakes and food sources of phytoestrogens in the European Prospective Investigation into Cancer and Nutrition (EPIC) 24-hour dietary recall cohort

BACKGROUND/OBJECTIVES: Phytoestrogens are estradiol-like natural compounds found in plants that have been associated with protective effects against chronic diseases, including some cancers, cardiovascular diseases and osteoporosis. The purpose of this study was to estimate the dietary intake of phytoestrogens, identify their food sources and their association with lifestyle factors in the Europea

Genetic Markers of Insulin Sensitivity and Insulin Secretion Are Associated With Spontaneous Postnatal Growth and Response to Growth Hormone Treatment in Short SGA Children: the North European SGA Study (NESGAS)

Purpose: The wide heterogeneity in the early growth and metabolism of children born small for gestational age (SGA), both before and during GH therapy, may reflect common genetic variations related to insulin secretion or sensitivity. Method: Combined multiallele single nucleotide polymorphism scores with known associations with insulin sensitivity or insulin secretion were analyzed for their rela

Facilitating collaboration: exploring a socio-technical approach to the design of a collaboratory for Library and Information Science

The thesis explores the potential of one way of facilitating and stimulating collaboration in Library and Information Science (LIS), through a specific scientific collaboration activity: creating, sharing and reusing data collection instruments, such as interview guides, questionnaires, and observation protocols. The four studies reported in the thesis can be read as a linear narrative, each study

Use of human amelogenin in molecular encapsulation for the design of pH responsive microparticles

Background: Proteins can be used in drug delivery systems to improve pharmacological properties of an active substance. Differences in pH between tissues can be utilized in order to achieve a targeted drug release at a specific location or tissue, such as a tumor. The enamel matrix protein amelogenin has a pH dependent solubility profile and self-assemble to form aggregates at neutral pH. This cou

A 10-year data set of basic meteorology and soil properties in central Sudan

Meteorological data and soil data have been collected at a site in the central Sudan from 2002 to 2012. The site is a sparse savanna in the semiarid region of Sudan. In addition to basic meteorological variables, soil properties (temperature, water content, and heat flux) and radiation (global radiation, net radiation, and photosynthetic active radiation) were measured. The dataset has a temporal

Levels of epitope-specific autoantibodies correlate with renal damage in anti-GBM disease

Background. Although the clinical importance of demonstrating the presence of anti-glomerular basement membrane (anti-GBM) antibodies is well established, less is known concerning the clinical utility of measuring the levels of autoantibodies. Two conformational epitopes of anti-GBM antibodies have been defined at residues 17-31 and 127-141 of the alpha 3(IV)NC1 domain of type IV collagen [alpha 3

Out-Sourcing the Inquisition: "Mass Dictatorship" in China's Cultural Revolution

This paper looks at an important yet little known component of what Chinese Communist Party Chairman Mao Zedong designated the “dictatorship of the masses”—the outsourcing by the supreme state leadership of selected surveillance, inquisitorial, and other violent tasks to what in a different political system would have been regarded as simply members of the public and/or non-governmental organizati

The Tumor Targeted Superantigen ABR-217620 Selectively Engages TRBV7-9 and Exploits TCR-pMHC Affinity Mimicry in Mediating T Cell Cytotoxicity.

The T lymphocytes are the most important effector cells in immunotherapy of cancer. The conceptual objective for developing the tumor targeted superantigen (TTS) ABR-217620 (naptumomab estafenatox, 5T4Fab-SEA/E-120), now in phase 3 studies for advanced renal cell cancer, was to selectively coat tumor cells with cytotoxic T lymphocytes (CTL) target structures functionally similar to natural CTL pMH

Spinal Epidural Lipomatosis: A Common Imaging Feature in Scheuermann Disease.

STUDY DESIGN: Retrospective study. OBJECTIVES: To find out if spinal epidural lipomatosis (SEL) occurs more commonly among patients with Scheuermann disease than in the general population. SUMMARY AND BACKGROUND: On the basis of our own radiologic and operative observation, SEL seems to occur frequently in patients with Scheuermann disease. METHODS: Magnetic resonance imaging of 87 individuals

Mass shell smearing effects in top pair production

The top quark pair production and decay are considered in the framework of the smeared-mass unstable particles model. The results for total and differential cross-sections in vicinity of t (t) over bar threshold are in good agreement with the previous ones in the literature. The strategy of calculations of the higher order corrections in the framework of the model is discussed. Suggested approach

Protein kinase Cα suppresses the expression of STC1 in MDA-MB-231 breast cancer cells

Several protein kinase C (PKC) isoforms have been shown to influence different cellular processes that may contribute to the malignancy of breast cancer cells. To obtain insight into mechanisms mediating the PKC effects, global gene expression was analyzed in MDA-MB-231 breast cancer cells in which PKCα, PKCδ or PKCε had been down-regulated with siRNA. Gene set enrichment analyses revealed that hy

TDC Offset Estimation from Motored Cylinder Pressure Data based on Heat Release Shaping

Abstract in UndeterminedFinding the correct Top Dead Center (TDC) offset for an internal combustion engine is harder than it seems. This study introduces a novel method to find the TDC offset based on the simple assumption that the heat loss power through the combustion chamber walls is constant for motored cycles in a narrow Crank Angle interval around TDC. The proposed method uses nonlinear leas

Genetic Variations in Type 2 Diabetes and Cardiovascular Disease: A Focus on Gene-Lifestyle Interactions and Mendelian Randomization

Popular Abstract in English The prevalence of type 2 diabetes (T2D) and cardiovascular disease (CVD) is increasing in epidemic proportions around the globe. This epidemic accounts for huge health and economic burdens as a leading cause for morbidity and mortality. The development of these diseases is very complex and involves both genetic and lifestyle factors. The shift to sedentary lifestyles anType 2 diabetes (T2D) and cardiovascular disease (CVD) are highly prevalent complex diseases that result from lifestyle and genetic factors. Gene-lifestyle interactions are also believed to contribute to the etiology of these diseases. The aim of this thesis was to investigate gene-lifestyle interactions using the strongest T2D and CVD susceptibility genetic loci and to understand the causal natur

Associations between estimated acrylamide intakes, and hemoglobin AA adducts in a sample from the Malmö Diet and Cancer cohort.

Objective: To examine the coherence of estimated intakes of acrylamide (AA) from foods, with hemoglobin (Hb) AA adduct levels, an objective marker of environmental AA exposure. Design: A cross-sectional study. Setting: The Malmö Diet and Cancer study, a large population-based prospective cohort (n=28 098) in the south of Sweden. Subjects: A sample of non-smoking (n=70) and smoking (n=72) w