Calcitonin gene-related peptide (CGRP) has a key role in the pathophysiology of migraine and is associated with activation of the trigeminovascular system. Recently, CGRP receptor antagonists have been developed with clinical efficacy. The present thesis aimed therefore to investigate the distribution of CGRP and the CGRP receptor in the trigeminovascular system and in parts of the CNS. In the tri

One of multiple functions of metalloproteins is to provide detoxification to excess metal levels in organisms. Here we address the induction and persistence of a range of low to high molecular weight copper- and zinc binding proteins in the collembolan species Tetrodontophora bielanensis exposed to copper- and zinc-enriched food, followed by a period of recovery from metal exposure, in absence and

Popular Abstract in Swedish Tolkning av medicinska bilder kan vara svår och påverkar i hög grad det fortsatta handläggandet av patienten. De viktigaste förutsättningarna för ett bra tolkningsresultat är förutom läkarens erfarenhet, som byggs upp genom att tolka många bilder, även kvaliteten på bilderna. Under det senaste decenniet har bilddiagnostiken utvecklats snabbt. Digitaliseringen av bilden Correct interpretation of medical imaging is based upon the interpreter’s experience and image quality. Depending on the report given the clinician decides how to use the result of the study. For many years a large number of image technologies including myocardial perfusion scintigraphy (MPS) have been acquired in digital format and the development of the imaging modalities are progressing rapidly

Popular Abstract in Swedish Ultraljud kan avslöja farliga plack Stroke orsakas ofta av att en blodpropp, som utvecklats i de områden av blodkärlen som drabbats av åderförkalkning, täpper till ett blodkärl som försörjer hjärnan med blod. Genom att med ultraljud studera de plack som utgör åderförkalkningen, kan man få ytterligare information för att bedöma en individs risk att drabbas av stroke. HjäAtherosclerotic plaques in the carotid arteries are common in a middle-aged population. When a carotid plaque ruptures it may result in a cerebrovascular event. However, only a minor part of carotid plaques will eventually rupture. Finding those plaques is essential to decide the most appropriate treatment strategy. With non-invasive ultrasound the carotid plaques can be visualized for assessment

Assays detecting antigen (Ag)-specific T-cell responses in immune-mediated processes are increasingly employed to understand disease pathogenesis and "immune staging". The quantity and quality of starting peripheral blood mononuclear cell (PBMC) preparations are important factors in the performance of such assays. We therefore compared final PBMC yield and function by modifying parameters at the b

We analyze the Ce3+-Pr3+:Y2SiO5 emission spectra obtained under selective excitation of the two Ce3+ sites in Y2SiO5 and we show clear evidence of direct energy transfer from Ce3+ to Pr3+. Energy transfer microparameters were calculated from the experimental spectral overlap between the Ce3+ emission and the Pr3+ and Eu3+ absorptions from which, the transfer mechanisms Ce3+-> Pr3+ are concluded to

A general approach to the modifications of the spectrum of a laser pulse interacting with matter is elaborated and used for spectral diagnostics of laser wakefield generation in guiding structures. Analytical predictions of the laser frequency red shift due to the wakefield excited in a capillary waveguide are confirmed by self-consistent modeling results. The role of ionization blue shift, and no

Background: The clinical and demographic variables defining the heterogeneity of chronic obstructive pulmonary disease (COPD) are unclear. A post-hoc analysis of five randomised studies in patients with a history of previous exacerbations examined the clinical and demographic characteristics describing moderate-to-very-severe COPD. Methods: Factor analysis was performed on all continuous baseline

The exact role of fluid mechanics in the patho-physiological process of atherosclerosis has been a research topic over many years, yet without clear conclusive result. One has observed that morphological manifestations of the disease are found at some well-defined locations: certain vessel bifurcations and in curvatures. The flow in these regions is characterized by unsteadiness and often separati

Using x-ray photoelectron spectroscopy, thermal desorption spectroscopy, and scanning tunneling microscopy, we show that upon keV Xe+ irradiation of graphene on Ir(111), Xe atoms are trapped under the graphene. Upon annealing, aggregation of Xe leads to graphene bulges and blisters. The efficient trapping is an unexpected and remarkable phenomenon given the absence of chemical binding of Xe to Ir

In this review, we summarize a series of experimental studies of the swelling of zwitterionic lamellar phospholipid and phospholipid-cholesterol systems using a novel double twin calorimeter. With this method, one can obtain simultaneous measures of the partial molar free energy and the partial molar enthalpy, and the experimental studies thus provide a complete thermodynamic characterization of t

Intra--arterial thrombolysis has become the most important minimal--invasive treatment option to treat acute lower limb ischemia. Although hemorrhagic stroke is a dreaded complication, it is considered beneficial to many fragile and elderly patients where vascular surgery is not an option. This review outlines current results after intra--arterial thrombolysis with low dose recombinant tissue plas

Diverse physiological processes are regulated differentially by Ca2+ oscillations through the common regulatory hub calmodulin. The capacity of calmodulin to combine specificity with promiscuity remains to be resolved. Here we propose a mechanism based on the molecular properties of calmodulin, its two domains with separate Ca2+ binding affinities, and target exchange rates that depend on both tar

Based on the Constructal Theory, parallel-flow and counterflow microchannels heat sinks with bifurcations are put forward to manage the temperature nonuniformity and further reduce the temperature of microchannel heat sinks bottom plates. Several models with different lengths of bifurcations are designed, and the corresponding laminar fluid flow and heat transfer of all models have been investigat

With rising concentrations of both atmospheric carbon dioxide (CO2) and tropospheric ozone (O-3), it is important to better understand the interacting effects of these two trace gases on plant physiology affecting land-atmosphere gas exchange. We investigated the effect of growth under elevated CO2 and O-3, singly and in combination, on the primary short-term stomatal response to CO2 concentration