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Intracellular mechanisms in rd1 mouse retinal degeneration
Popular Abstract in Swedish Ärftlig blindhet orsakas oftast av sjukdomar där näthinnans fotoreceptorer, som ombesörjer omvandlingen av ljus till elektriska impulser, degenererar. Det anses att denna celldödsprocess styrs av ett antal olika mekanismer och projektets mål är att försöka identifiera och karaktärisera dessa mekanismer. Retinitis Pigmentosa (RP) är en ärftlig sjukdom där en genetisk defRetinitis pigmentosa (RP) is an inherited disorder and the leading cause of visual impairment in the working age population. It is caused by a number of different genetic mutations, all of which cause the rod photoreceptors to degenerate. As the rods become few in numbers, the cones will also begin to die, resulting in total blindness. Since the genetic defects leading to RP are numerous, it would
Fast on-column protein digestion with subsequent peptide mapping using tandem mass spectrometry with information dependent acquisition
A platform for rapid on-line protein digestion of protein mixtures for direct infusion to a mass spectrometer is presented. A mixture of protein A, staphylococcal enterotoxin B and cytochrome c was used as a model mixture injected on a gel filtration column and a trypsin reactor which were connected in series to a micro liquid chromatography (mu LC) system. The peptides in the column eluate were a
Erythropoietin treatment in metastatic breast cancer--effects on Hb, quality of life and need for transfusion.
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Byggnadsmaterialforskning vid LTH : Del 3. Praktikfall
Analysis of effector pathways in arthritis
Rheumatoid arthritis (RA) is a multifactorial, polygenic autoimmune disease. For effective treatment and control of RA, understanding of disease pathways and identification of genes involved are essential. Animal models are efficient tools to identify such pathogenic mechanisms and genes underlying the disease process. In the present study, collagen antibody induced arthritis (CAIA), a mouse model
ICPD@ten: is reproductive health under fire?
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Strategy-proof voting on the full preference domain
In analyses of strategy-proof voting, two results feature prominently: the dictatorial characterization contained in the Gibbard-Satterthwaite theorem and the voting by committees characterization in the Barbera-Sonnenschein-Zhou theorem. The two theorems are based on voting procedures defined on the domain of strict preferences. In the present study, we derive corresponding results for voting sch
A Nonlinearity with Adjustable Phaseshift
Rättens utveckling i den globala byn
Hittills har rättssociologi nästan uteslutande studerat rättens funktioner, utveckling och förändring inom dem samhälleliga ramar som inrättats i enlighet med den traditionella nationalstatens grundprinciper. Under de senare decennierna har det emellertid vuxit fram en omfattande metanationell verksamhet med sin egen utvecklingsmekanism och rationalitet, som i sitt verkningssätt tycks vara oberoen
Von den Nachbarn lernen? Deregulierung und Re-Regulierung in den Niederlanden und
Reactions to awareness of activated protein C resistance carriership: a descriptive study of 270 women.
Background. Around 25 million Caucasian women are carriers of the FV Leiden mutation that causes activated protein C (APC) resistance. This is a heritable condition with a lifelong increased risk of venous thromboembolism. We performed this study to investigate women's reactions to their awareness of being APC-resistant and the consequences of this awareness. Methods. All APC-resistant women (n =
Hushållskunder på energimarknaden
Man kan identifiera fem stora kundsegment på energimarknaden nämligen hushåll i småhuslägenheter, hushåll i flerbostadshusen lägenheter, fastighetsägare till flerbostadshus, unga hushåll samt medelålders och äldre hushåll. Jämfört med energiföretagens andra kundsegment inom exempelvis industri, handel, service eller myndigheter är hushållssegmenten oorganiserade. De innehåller många hushåll med be
Utveckling av miljöredovisning i svenska börsbolag : praxis, begrepp, orsaker
Before 1990 environmental reporting in Sweden was a marginal and unsystematic activity undertaken by a small number of large companies in high-profile industries. The 1990's have witnessed a dramatic increase in environmental reporting practice, and today a large number of companies in almost all industries annually report considerable amounts of environmental information. Increasingly, companies
Complexes between activated protein C and protein C inhibitor measured with a new method: comparison of performance with other markers of hypercoagulability in the diagnosis of deep vein thrombosis
A first clinical evaluation has been made of the performance of a newly devised immunofluorometric assay for measuring plasma concentrations of activated protein C (APC) in complex with protein C inhibitor (PCI). The method was compared with testing for other markers of hypercoagulability in a case-control study comprising 123 patients with clinical suspicion of deep vein thrombosis (DVT). The dia
Lund contributions to the Eight international congress of Slavists in Zagreb - Ljubljana
Validation of the Rheumatoid and Arthritis Outcome Score (RAOS) for the lower extremity
BACKGROUND: Patients with inflammatory joint diseases tend due to new treatments to be more physically active; something not taken into account by currently used outcome measures. The Rheumatoid and Arthritis Outcome Score (RAOS) is an adaptation of the Knee injury and Osteoarthritis Outcome Score (KOOS) and evaluates functional limitations of importance to physically active people with inflammato
Structure of reduced and oxidized manganese superoxide dismutase: A combined computational and experimental approach
Manganese superoxide dismutases catalyze the disproportionation of the superoxide radical anion to molecular oxygen and hydrogen peroxide. Recently, atomic-resolution crystal structures of the reduced and oxidized enzymes have been reported. They show an active site with the manganese ion bound to one aspartate, three histidine residues, and a solvent molecule. In this paper, we combine crystallog