Brain structure and function are intimately linked, however this association remains poorly understood and the complexity of this relationship has remained understudied. Healthy aging is characterised by heterogenous levels of structural integrity changes that influence functional network dynamics. Here, we use the multilayer brain network analysis on structural (diffusion weighted imaging) and fu

OBJECTIVE: Diffusion tensor imaging (DTI) along the perivascular space (ALPS) (DTI-ALPS)-by calculating the ALPS index, a ratio accentuating water diffusion in the perivascular space-has been proposed as a noninvasive, indirect MRI method for assessing glymphatic function. The main aim of this study was to investigate whether DTI-ALPS would reveal glymphatic dysfunction in idiopathic normal pressu

Det är mycket rörelse på AI-fronten nu – både rättsligt, tekniskt och politiskt. Stefan Larsson, jurist och docent i teknik och social förändring vid Lunds universitet, placerar in EU-lagstiftarens AI-förordning i en både global och svensk kontext. Han beskriver processen bakom lagstiftningen, de etiska och principiella grunderna, och hur EU-lagstiftaren hanterar AI-innovationernas explosionsartad

Efficient recycling and upcycling strategies to retain the material in the economy and away from the ecosystems are important to achieve a sustainable plastic system. Poly(butylene adipate-co-terephthalate) (PBAT) is a biodegradable polyester that has gained considerable interest for various applications. Here, we report a study on enzymatic depolymerization of PBAT, recovery and purification

Compositional heterogeneity is commonly observed in mixed bromide/iodide perovskite photoabsorbers, typically with minimal effects on charge carrier recombination and photovoltaic performance. Consistently, it has so far received very limited attention in bromide/chloride-mixed perovskites, which hold particular significance for blue light-emitting diodes. Here, we uncover that even a minor degree

Conceptual design studies performed with reduced-order approaches allow feasibility and sizing considerations of air-breathing engines to be configured at an affordable computational cost. The present study is devoted to exploring the design space of a dual-mode ramjet engine operating in scramjet mode by means of reduced-order analysis to assess the effects of propulsive system design configurati

The spatial distribution of muscle fibre activity is of interest in guiding therapy and assessing recovery of motor function following injuries of the peripheral or central nervous system. This paper presents a new method for stable estimation of motor unit territory centres from high-density surface electromyography (HDsEMG). This completely automatic process applies principal component compressi

Metals are significant contributors to water pollution, posing serious threats to human health. This study aims to assess the carcinogenic and non-carcinogenic health risks associated with metals in Isfahan drinking water. Eighty water samples were randomly collected from the city's distribution network between January and March 2020–2021. Inductively coupled plasma Optical Emission Spectrometry w

We present property probes, a mechanism for helping a developer explore partial program analysis results in terms of the source program interactively while the program is edited. A node locator data structure is introduced that maps between source code spans and program representation nodes, and that helps identify probed nodes in a robust way, after modifications to the source code. We have devel

Background: The clinical meaningfulness of the effects of recently approved disease-modifying treatments (DMT) in Alzheimer’s disease is under debate. Available evidence is limited to short-term effects on clinical rating scales which may be difficult to interpret and have limited intrinsic meaning to patients. The main value of DMTs accrues over the long term as they are expected to cause a delay

Purpose: To examine associations of prenatal biomarkers of pesticide exposure with birth size measures and length of gestation among newborns from the Infants' Environmental Health (ISA) birth cohort, Costa Rica. Methods: We included 386 singleton liveborn newborns with data on birth size measures, length of gestation, and maternal urinary biomarkers of chlorpyrifos, synthetic pyrethroids, mancoze

INTRODUCTION: Parkinson's disease (PD) is the second most common neurodegenerative disorder, increasing both in terms of prevalence and incidence. To date, only symptomatic treatment is available, highlighting the need to increase knowledge on disease etiology in order to develop new therapeutic strategies. Hemizygosity for the gene Engrailed-1 ( En1), encoding a conserved transcription factor ess

Fe(II) N-heterocyclic carbene (NHC) complexes have emerged over the last decade as a promising class of light-harvesting complexes for a variety of photochemical applications relying on the presence of high-energy excited states of mainly charge-transfer character with excited state lifetimes of tens of picoseconds or longer. Recent spectroscopic investigations have significantly refined the under

n Charity in Saudi Arabia, Nora Derbal challenges the existing literature on Saudi Arabia’s civil society, giving space and voice to some of its more underappreciated actors. The book includes a mix of personal experiences, ethnographic observation, and detailed descriptions of four civil society organizations (CSOs) and their evolution from 2009 to 2020. In the aftermath of the 2009 flood in Jedd

In this work we computed the phase diagram as a function of temperature and doping for a system of lead adatoms allocated periodically on a silicon (111) surface. This Si(111):Pb material is characterized by a strong and long-ranged Coulomb interaction, a relatively large value of the spin-orbit coupling, and a structural phase transition that occurs at low temperature. In order to describe the co

The combined challenge of climate change and population aging requires novel solutions that enhance the resilience of building energy systems and secure indoor comfort for vulnerable occupants in extreme weather conditions. This research investigates the performance of a newly developed Energy Management (EM) system based on Collective Intelligence (CI) and Reinforcement Learning (RL), called CIRL

Out of hospital cardiac arrest (OHCA) outcomes can be improved by strengthening the chain of survival, namely prompt cardiopulmonary resuscitation (CPR) and automated external defibrillator (AED). However, provision of bystander CPR and AED use remains low due to individual patient factors ranging from lack of education to socioeconomic barriers and due to lack of resources such as limited availab

Though new targeted therapies for colorectal cancer, which progresses from local intestinal tumors to metastatic disease, are being developed, tumor specificity remains an important problem, and side effects a major concern. Here, we show that the protein-fatty acid complex BAMLET (bovine alpha-lactalbumin made lethal to tumor cells) can act as a peroral treatment for colorectal cancer. ApcMin/+ m

The changing nature of the migration phenomenon has influenced the Moroccan context in a different way and has transformed it into a transit and destination country for sub-Saharan migrants. This chapter analyses the evolution of migration trends in Morocco, considering the relation between migration and development in more marginalised areas of the country, such as the Rif region. Moreover, it co