Fusion genes are potent driver mutations in cancer. In this study, we delineate the fusion gene landscape in a consecutive series of 195 paediatric B-cell precursor acute lymphoblastic leukaemia (BCP ALL). Using RNA sequencing, we find in-frame fusion genes in 127 (65%) cases, including 27 novel fusions. We describe a subtype characterized by recurrent IGH-DUX4 or ERG-DUX4 fusions, representing 4%

How are we to understand the perplexing and sometimes even counter-intuitive position of Denmark in relation to Justice and Home Affairs (JHA)? In this article, we attempt to go behind the many myths and misunderstandings involved and analyse the consequences of the Danish opt-out from EU cooperation in Justice and Home Affairs. Symbolically, the opt-out plays a major role for large parts of the D

We investigate the mechanisms of knowledge governance and show that the actual economic benefits stemming from knowledge externalities depend on the characteristics of (a) the sources of such externalities, (b) the context in which spillovers take place, (c) the potential users of the externalities. In the Italian experience of 1950-1994, state owned enterprises (SOE) have been one of the most eff

It is estimated that there are over a million pornographic sites on the Internet, with as many as 10,000 added every week. In addition to having a major financial impact, adult pornography is strongly as- sociated with various types of violence against women, especially sexual assault. Some studies have found that the contribution of pornography to woman abuse in dating, marriage, and during or af

Background and purpose — Randomized trials have found that treating spinal burst fractures with reduction and posterior fixation is adequate without the use of bone grafting for definitive fusion. Restitution of intervertebral mobility of such an unfused segment after fracture healing may unload the adjacent parts of the spine and reduce the risk of degeneration of these segments. We used radioste

Background Transcatheter aortic valve replacement (TAVR) has become an established therapeutic option for patients with symptomatic, severe aortic valve stenosis (AS) who are ineligible or at high risk for conventional valvular surgery. In Northwestern Europe, the TAVR technology is also increasingly used to treat patients with an intermediate risk profile. Methods and results The study was design

Creating bimodal grain size distribution in crystalline materials is an effective strategy to improve structural efficiency. Present investigation demonstrates that further control over topology through the formation of bimodal 'harmonic' structure simultaneously increases average values of strength and ductility, reduces the variation of corresponding properties, and thwarts the localization of p

The 19th century was a period of great transformations for Italy. Political unification was achieved in 1861 while economic unification was still far off. Ever since, Italian industrialization has been unbalanced, as the pre-existing gap between Northern and Southern economic development has widened. In this context, the creation of the Italian national market has been a highly debated topic. Orig

The overall aim of this thesis is to develop knowledge of teaching and learning sustainable development in global–local contexts. The research field is global learning for sustainable development (GLSD). Phenomenographic approach and contextual analysis were used as methods of analysis, and data was collected by Semi-structured interviews at secondary and upper secondary schools in Sweden.In Study

This chapter explores gay and lesbian police officers’ stories of marginalization and the limits of inclusive diversity policies in the Swedish police. The analysis aims to go beyond the level of policy and formal training and consider mechanisms of exclusion and marginalization on the level of personal stories based on lived experience. Drawing on an interview study of gay and lesbian police offi

This paper presents results from time-optimal path tracking for industrial robots. More specifically, three subproblems are studied and experimentally evaluated. The first is a contact-force control approach for determining the geometric robot motion, such that the tool centre point of the robot is moved according to the specification. The second problem is off-line solution of the optimisation pr

Objective: The aim of this study was to compare the outcome of immediate versus delayed radical prostatectomy (RP) in men with low-grade prostate cancer. Materials and methods: The study included a nationwide population-based cohort in the National Prostate Cancer Register of Sweden, of 7608 men with clinically localized, biopsy Gleason score 6 prostate cancer who underwent immediate or delayed RP

This paper presents a method for modeling and control of a piezo-actuated high-dynamic compensation mechanism (HDCM) for usage together with an industrial robot during a machining operation, such as milling in aluminum. The spindle is attached to the compensation mechanism and the robot holds the workpiece. Due to the inherent resonant character of mechanical constructions of this type, and the no