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Hierarchical Clustering and Trajectory Analyses Reveal Viremia-Independent B-Cell Perturbations in HIV-2 Infection

Time to AIDS in HIV-2 infection is approximately twice as long compared to in HIV-1 infection. Despite reduced viremia, HIV-2-infected individuals display signs of chronic immune activation. In HIV-1-infected individuals, B-cell hyperactivation is driven by continuous antigen exposure. However, the contribution of viremia to B-cell perturbations in HIV-2-infected individuals remains largely unexpl

Insights into source/sink controls on wood formation and photosynthesis from a stem chilling experiment in mature red maple

Whether sources or sinks control wood growth remains debated with a paucity of evidence from mature trees in natural settings. Here, we altered carbon supply rate in stems of mature red maples (Acer rubrum) within the growing season by restricting phloem transport using stem chilling; thereby increasing carbon supply above and decreasing carbon supply below the restrictions, respectively. Chilling

Distriktssköterskan inom barnhälsovården - En systematisk litteraturstudie om distriktssköterskans perspektiv av bemötande med barn och familj

Bakgrund: Barnhälsovården följer de globala målen enligt Socialstyrelsen (2014) om att främja barnets hälsa som medfört att det har blivit mer inriktat på hälsovård. I sjuksköterskans arbete är det betydelsefullt att involvera familjen för att skapa ett gott bemötande, vilket leder till bättre samverkan i mötet. Syfte: Syfte med studien var att beskriva bemötande av barn och familj utifrån distrik

Distriktssköterskan inom barnhälsovården - En systematisk litteraturstudie om distriktssköterskans perspektiv av bemötande med barn och familj

Bakgrund: Barnhälsovården följer de globala målen enligt Socialstyrelsen (2014) om att främja barnets hälsa som medfört att det har blivit mer inriktat på hälsovård. I sjuksköterskans arbete är det betydelsefullt att involvera familjen för att skapa ett gott bemötande, vilket leder till bättre samverkan i mötet. Syfte: Syfte med studien var att beskriva bemötande av barn och familj utifrån distrik

The evolution of predator avoidance in cephalopods : A case of brain over brawn?

Predation is a major evolutionary driver of animal adaptation. However, understanding of anti-predator evolution is biased toward vertebrate taxa. Cephalopoda, a class in the invertebrate phylum Mollusca, are known for their diverse anti-predator strategies, characterised by their behavioural flexibility. While ancestral cephalopods were protected by a hard outer shell, extant cephalopods have gre

MSCs interaction with the host lung microenvironment : An overlooked aspect?

Mesenchymal stromal cells (MSCs) were identified more than 50 years ago, and research advances have promoted the translation of pre-clinical studies into clinical settings in several diseases. However, we are only starting to uncover the local factors that regulate cell phenotype, cell function, and cell viability across tissues following administration in different diseases. Advances in pre-clini

The mosaic oat genome gives insights into a uniquely healthy cereal crop

Cultivated oat (Avena sativa L.) is an allohexaploid (AACCDD, 2n = 6x = 42) thought to have been domesticated more than 3,000 years ago while growing as a weed in wheat, emmer and barley fields in Anatolia1,2. Oat has a low carbon footprint, substantial health benefits and the potential to replace animal-based food products. However, the lack of a fully annotated reference genome has hampered effo

Genome-Wide Association Study of Salt Tolerance-Related Traits during Germination and Seedling Development in an Intermedium-Spike Barley Collection

Increased salinity is one of the major consequences of climatic change affecting global crop production. The early stages in the barley (Hordeum vulgare L.) life cycle are considered the most critical phases due to their contributions to final crop yield. Particularly, the germination and seedling development are sensitive to numerous environmental stresses, especially soil salinity. In this study

Causal analysis of plasma IL-8 on carotid intima media thickness, a measure of subclinical atherosclerosis

BACKGROUND: We investigated the causality of IL-8 on carotid intima-media thickness (c-IMT), a measure of sub-clinical atherosclerosis.METHODS: The IMPROVE is a multicenter European study (n = 3,711). The association of plasma IL-8 with c-IMT (mm) was estimated by quantile regression. Genotyping was performed using the Illumina CardioMetabo and Immuno chips. Replication was attempted in three inde

Jihadi Kitsch: The Promesse de Bonheur of Islamist Terrorism

Elaborating on conceptualizations of kitsch in the realm of art and sociology in the context of ISIS propaganda and culture, this article introduces the concept of jihadi kitsch. Kitsch is characterized by a compulsion to escape from the banality of daily reality and lack of coherent meaning in modern society through, in the words of the philosopher and sociologist Theodor Adorno, a self-made and Elaborating on conceptualizations of kitsch in the realm of art and sociology in the context of ISIS propaganda and culture, this article introduces the concept of jihadi kitsch. Kitsch is characterized by a compulsion to escape from the banality of daily reality and lack of coherent meaning in modern society through, in the words of the philosopher and sociologist Theodor Adorno, a self-made and

Diagnostic Dosimetry

Diagnostic nuclear medicine, more recently also named functional molecular imaging, deals with medical procedures performed to help diagnose a variety of diseases. The procedures are based on the use of tracer amounts of radioactive material, where a radionuclide is attached to a ligand with specific affinity to a physiological, metabolic, or receptor-specific process. To balance the benefit of a

Handbook of Nuclear Medicine and Molecular Imaging for Physicists : Modelling, Dosimetry and Radiation Protection, Volume II

Mathematical modelling is an important part of nuclear medicine. Therefore, several chapters of this book have been dedicated towards describing this topic. In these chapters, an emphasis has been put on describing the mathematical modelling of the radiation transport of photons and electrons, as well as on the transportation of radiopharmaceuticals between different organs and compartments. It al

Effects of Levodopa-Carbidopa Intestinal Gel on Dyskinesia and Non-Motor Symptoms Including Sleep : Results from a Meta-Analysis with 24-Month Follow-Up

Background: In advanced Parkinson's disease (PD), dyskinesias and non-motor symptoms such as sleep dysfunction can significantly impair quality of life, and high-quality management is an unmet need. Objective: To analyze changes in dyskinesia and non-motor symptoms (including sleep) among studies with levodopa-carbidopa intestinal gel (LCIG) in patients with advanced PD. Methods: A comprehensive l

Transmogrification or Forvandling? : The Translations of Ovid’s Metamorphoses by Ted Hughes and Otto Steen Due

Within a decade appeared two appraised translations of the Latin poet Ovid's Metamorphoses: the English Tales from Ovid by Ted Hughes, and the Danish Ovids forvandlinger by Otto Steen Due. Though in general true to Ovid's text, the two translations are markedly different, reflecting different traditions and different aims. Whereas Hughes centres on stories and their symbolic value, Due is more ben

Relation between perinatal outcome and gestational duration in term primiparous pregnancies stratified by body mass index

Introduction: There is growing evidence that induction of labor at 41 completed weeks improves neonatal outcome, at least among primiparous women. This study was performed to investigate whether maternal body mass index (BMI) should be considered when deciding on timing of intervention in term pregnancies. Material and methods: The study design was a historical cohort study using data from the Swe