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Older men with low serum estradiol and high serum SHBG have an increased risk of fractures
Osteoporosis-related fractures constitute a major health concern not only in women but also in men. To study the predictive role of serum sex steroids for fracture risk in men, serum sex steroids were analyzed by the specific gas chromatography-mass-spectrometry technique at baseline in older men (n = 2639; mean, 75 yr of age) of the prospective population-based MrOS Sweden cohort. Fractures occur
The hormone-sensitive lipase C-60G gene polymorphism is associated with abdominal obesity
Removal of endocrine-disrupting compounds from water using macroporous molecularly imprinted cryogels in a moving-bed reactor.
Highly efficient removal of endocrine-disrupting compounds (EDCs) such as 17beta-estradiol (E2), 4-nonylphenol (NP) and atrazine from water was achieved using a novel macroporous adsorption medium. The medium consisted of a macroporous poly(vinyl alcohol) (PVA) cryogel with molecularly imprinted polymer (MIP) particles embedded in it. The MIP was prepared using E2, NP and atrazine as templates. Th
Unstable flow theory and modeling
We use linear stability analysis to develop a theory which can predict traffic flow behavior for the unstable flow regime of concentrations. The equilibrium solution of the kinetic equation of Prigogine and Herman is used to obtain closed form models of traffic flow, when viewed under asymptotic (Chapman-Enskog) limit expansions, since it can produce reasonable flows for the whole range of concent
Complex spectra in fusion plasmas
The need for quantitative evaluation of complex line emission spectra as observed in hot fusion plasmas initiated a challenging development of sophisticated interpretation tools based on integrating advanced atomic modelling with detailed treatment of the plasma environment. The successful merging of the two worlds has led to routine diagnostic procedures which have contributed enormously to the u
Patient-reported swollen and tender 28-joint counts accurately represent RA disease activity and can be used to calculate DAS28 on a group level
The association between retinopathy, nephropathy, cardiovascular disease and long-term metabolic control in type 1 diabetes mellitus: a 5 year follow-up study of 442 adult patients in routine care
The aim of the present study was to examine mean HbA1c and blood pressure levels during a 5 year period in 442 type 1 adult diabetic patients in relation to the incidence and progression of retinopathy, nephropathy and to cardiovascular morbidity and mortality. The study showed, that in patients under routine care at a diabetic unit with four visits to the out-patient clinic per year, the intraind
Earth System governmentality Reflections on science in the Anthropocene
This paper examines Earth System Science as a novel approach to global environmental change research. Drawing upon Michel Foucault's governmentality concept, the paper opens up the Earth System metaphor to political analysis and asks what it does to our understanding of nature and society as a governable domain. We trace the scientific practices that have produced the Earth System as a thinkable a
Study of water dynamics and distances in paramagnetic solids by variable-temperature two-dimensional H-2 NMR spectroscopy
A recently proposed two-dimensional H-2 NMR experiment is used to measure the H-2 (spin I=1) quadrupolar and paramagnetic shift anisotropy interactions in powdered CuCl2 center dot 2D(2)O as a function of temperature. The principal components of the quadrupolar and paramagnetic shift anisotropy tensors and the Euler angles describing the orientations of the tensors in the molecular frame are deter
Lack of systemic anaphylaxis and aeroallergen-induced airway plasma extravasation in allergic immunoglobulin-deficient mice
BACKGROUND: In Ig-deficient mice allergen challenge-induced pulmonary late phase inflammation is at least as pronounced as in wild-type animals. This study investigates immediate hypersensitivity responses in these mice. METHODS: To examine the acute plasma extravasation response in airway tissue, immunized Ig-deficient and wild-type mice and sham-immunized wild-type controls were subjected to 15
General Protocols for the Synthesis of C(2)-Symmetric and Asymmetric 2,8-Disubstituted Analogues of Tröger's Base via Efficient Bromine-Lithium Exchanges of 2,8-Dibromo-6H,12H-5,11-methanodibenzo[b,f][1,5]diazocine.
Methods for facile synthesis of symmetric and unsymmetric functionalized analogues of Tröger's base were developed with use of 2,8-dibromo-6H,12H-5,11-methanodibenzo[b,f][1,5]diazocine (2) as the starting material. C(2)-symmetric 2,8-disubstituted analogues of Tröger's base (4a-f) were synthesized via double bromine-lithium exchange of 2 followed by quench with electrophiles. Desymmetrization via
Binding of antibodies to concanavalin A-modified monolithic cryogel
Binding of human immunoglobulin-G (IgG) from aqueous solutions and human plasma to concanavalin A (Con A) immobilized poly(acrylamide-allyl glycidyl ether) [poly(AAm-AGE)] monolithic cryogel has been studied. Poly(AAm-AGE) cryogel was prepared by bulk polymerization which proceeds in aqueous solution of monomers frozen inside a column (cryo-polymerization). After thawing, the monolithic cryogel co
Fixation of fractures of the femoral neck - Reply
Influence of the alkali metal salt on the properties of solid electrolytes derived from a Lewis acidic polyether
A polyether containing Lewis acidic boron atoms in its branched chain architecture was synthesised by a condensation reaction of boron trioxide, triethylene glycol monomethyl ether and poly(ethylene glycol), the latter having a molecular weight of 300 g/mol. Electrolytes based on this polymer and several different alkali metal salts were prepared and investigated. The state of the ions in the elec
Antibody responses against B-cell epitopes of the hypervariable region 1 of hepatitis C virus in self-limiting and chronic human hepatitis C followed-up using consensus peptides
A rare collection of serum samples from patients with hepatitis C virus (HCV) infection followed up from the onset of clinical symptoms was acquired. RNA corresponding to the hypervariable region 1 (HVR1) of E2 protein of HCV isolated from nine patients was reverse-transcribed, amplified, sequenced, and HVR1 amino acid sequences were deduced. These sequences and a selection of HVR1 amino acid sequ
Imperatives in health care. Implications for social welfare and medical technology
Sprouting of bladder nerves into cystoplastic cecal segment in the rat.
Incorporation of bowel into the bladder (enterocystoplasty) has been widely used to increase bladder capacity. It has been reported by others that the response of smooth muscle from the cystoplastic segment of the intestine shifts from that of the intestine (relaxation to α-agonists and ATP) to that of the bladder (contraction to α-agonists and ATP). This suggests a functional integration of the i
Novel nanoelectronic device applications based on the nonlinearity of three-terminal ballistic junctions
Nanometer-scale electron devices containing three-terminal ballistic junctions are fabricated by electron-beam lithography on InP/InGaAs two-dimensional electron gas materials. Based on the intrinsic nonlinearity of the devices, frequency mixer, phase detector and RS flip-flop memory functioning at room temperature are successfully achieved. The devices have simple structure layout and small size,
First records of Microptila Ris (Trichoptera: Hydroptilidae) from Japan, with description of a new species
Microptila orienthula, sp. n. from Japan is described and illustrated based on adults of both sexes. The new species represents the first finding of Microptila in the Eastern Palaearctic Region, and it appears to be more closely related to Oriental species of Microptila than to the two Western Palaearctic species. The finding of a new species with affinities to the Oriental species as far northeas
