Background: The UICC TNM 7th edition introduced stage groups for anal cancer which in 2019 has not yet come into general use. The new TNM 8th edition from 2016 defines 7 sub-stages. Background data for these changes are lacking. We aimed to investigate whether the new classification for anal cancer reliably predict the prognosis in the different stages. Patients and methods: The Nordic Anal Cancer

The oral glucose tolerance test (OGTT) is used to diagnose gestational and other types of diabetes. We examined metabolite changes during an OGTT, and how a comprehensive diet and physical activity intervention may influence these changes in a population of overweight/obese Hispanic pregnant women. Integration of changes in metabolites during an OGTT may help us gain preliminary insights into how

There is an established link between birth parameters and risk of adult-onset cancers. The Developmental Origins of Health and Disease concept provides potential underlying mechanisms for such associations, including intrauterine exposure to endogenous hormones (androgens and estrogens), insulin-like growth factors, etc. However, there is conflicting evidence on the association between birth param

Tobaksrökning är som tur är på nedåtgående i de flesta länder. Ändå är tobaksodlingen fortfarande en stor industri och många hoppas på att hitta nya användningsområden för denna giftiga växt. Lars Olof Björn och Ingvar Kärnefelt berättar tobakens historia ur ett både botaniskt och mänskligt perspektiv.

Field studies were conducted during three years to determine the vertical (height level) and horizontal (distance from stand edge) distribution of flying Neodiprion sertifer (Geoffroy) males in a non-outbreak population. Sticky traps baited with synthetic female pheromone (25, 35, 75-diprionyl acetate) were used in a mature stand of Scots pine (Pinus sylvestris L.) in Central Europe (southern Bohe

Research into Alzheimer's disease is still hampered by a lack of fundamental understanding of the underlying mechanisms. While the aggregation of the amyloid β peptide (Aβ) into amyloid fibrils is highly implicated as a key factor in the disease, the molecular nature of its involvement has proven complex and elusive. This thesis and the work herein is part of an ongoing effort to map out the aggre

Background: Circulating levels of TNF alpha receptor 1 (TNFR1) and 2 (TNFR2) are associated with increased long-term mortality and impaired kidney function. Aim: To study association between circulating levels of TNFR1 and TNFR2 and short-term mortality in patients with diabetes and dyspnea. Population and methods: Patients aged ≥ 18 years seeking at emergency department (ED) during daytime on wee

Food security is one of the world’s greatest challenges. The current food system shows an entanglement across the globe which means that local farmers reliant on subsistence agriculture no longer operate in isolation of larger-scale processes within the global economy or the changing biophysical system of the planet. The persistently high number of undernourished people, volatile food prices, incr

We present multiband photometry covering ∼5° × 5° across ω Cen collected with the Dark Energy Camera on the 4 m Blanco telescope, combined with Hubble Space Telescope and Wide Field Imager data for the central regions. The unprecedented photometric accuracy and field coverage allows us to confirm the different spatial distribution of blue and red main-sequence stars, and of red giant branch (RGB)

Ett universitets värde bestäms delvis av kvaliteten på de samtal som förs där. Utifrån vad vi vet om kreativa processer kan man anta att bra samtal leder till bra idéer som i sin tur leder till god utveckling på längre sikt.Men vilka förutsättningar krävs för att det goda samtalet ska kunna komma till stånd? Hur påverkas våra samtal och därmed våra samarbeten i Corona-tider när i stort sett all ve

(Z, Z)-3, 9-cis-6, 7-Epoxyheptadecadiene, and (Z, Z)-6, 9-cis-3, 4-epoxyheptadecadiene were identified by gas chromatography/flame ionization detection-electroantennographic detection (GC/FID-EAD) and coupled gas chromatography-mass spectrometry (GC-MS) from abdominal tip extracts of Tephrina arenacearia (Lepidoptera: Geometridae), an alfalfa pest. In gas chromatography/flame ionization—single sen

The nature of variation in moth pheromone communication systems and its genetic control is critical for the evolution of these systems and for their role in mate‐finding and reproductive isolation. Significant additive genetic variance has been demonstrated in female pheromone production in monomorphic populations. However, corresponding variance in male pheromone response with respect to the blen

Statoil has implemented a structured approach for assessing the condition of the safety barriers on their processing facilities as a key measure to control and reduce major accident risk. The TTS (Teknisk Tilstand Sikkerhet, Norwegian for technical condition safety) methodology is developed with a strong focus on assessing the actual conditions of the technical safety barriers in place to manage m

Terrestrial ecosystem gross primary productivity (GPP) is the largest land-atmosphere carbon flux and the primary mechanism of photosynthetic fixation of atmospheric CO2 into plant biomass. Anomalous rainfall events have been shown to have a great impact on the global carbon cycle. However, less is known about the impact of these events on GPP, especially in Africa, where in situ observations are

AbstractThis thesis investigates the use of digital resources in education with a 1-1 computer to student ratio. Studies were performed with a sociocultural perspective and in the light of the theory of affordances. The two studies differ methodologically but the shared topic is teachers’ usage of digital resources. Previous studies have shown that using digital resources to promote collaboration,

The Kumamoto area includes 11 municipalities and a population of about one million. The area represents the largest total use of groundwater in Japan. The main recharging area for this groundwater used to be paddy fields for rice production located along the mid-stream section of the Shirakawa River. In the past few decades, the area of paddy fields has rapidly decreased due to the Japanese govern