Dermatan sulfate (DS) chains are variants of chondroitin sulfate (CS) that are expressed in mammalian extracellular matrices and are particularly prevalent in skin. DS has been implicated in varied biological processes including wound repair, infection, cardiovascular disease, tumorigenesis, and fibrosis. The biological activities of DS have been attributed to its high content of IdoA(alpha 1-3)Ga

Popular Abstract in Swedish Primärt Sjögrens syndrom är en reumatisk systemsjukdom, som karaktäriseras av nedsatt funktion i vissa körtlar, framför allt i tårkörtlar och spottkörtlar. Detta orsakar huvudsymptomen ögon- och muntorrhet. Patienter med denna sjukdom har även besvär som inte är relaterade till dessa körtlar. Smärta i leder och muskler, extrem trötthet samt nedstämdhet är vanliga problePrimary Sjögren´s syndrome (primary SS) is a systemic autoimmune rheumatic disease characterized by lymphocytic infiltrations in the exocrine glands leading to classic dryness complaints such as dry eyes and dry mouth. Non-exocrine complaints also occur, e.g. fatigue, myalgia and arthralgia, as well as disturbed mood. The overall purpose of this work was, from a physiotherapeutic perspective, to i

OBJECTIVE: Limited data concerning serum lipids and lipoproteins are available on the effect of HRT in perimenopausal women, who commonly have marked bleeding disturbances and may have severe climacteric symptoms. Almost all previously published data have utilized a simplified form of lipoprotein analysis, which includes an estimation and not a determination of LDL cholesterol. To delineate the ro

We present an approach proving the integrability of the Camassa-Holm equation for initial data of small amplitude.

Purpose:To study survival in two groups of dysphagic patients - one group unable to elicit the pharyngeal stage of swallow (APS) and another group with pharyngeal swallow (WPS) - and to compare recommendations regarding nutrition and therapeutic strategies based on the therapeutic swallowing study. Material and Methods: In this retrospective study, the records of dysphagic patients who have under

Using time-resolved laser spectroscopy we have determined the hyperfine structure in the 3s2n p2P3/2 sequence of27Al (I=5/2). The magnetic-dipole interaction constants were found to scale withn*-2.85 (n* is the effective principal quantum number) in the investigated regionn=6–12. Significant quadrupole interaction constants were obtained forn=6–9. The measured radiative lifetimes forn=6–12 scale w

Transition metal polypyridine complexes are finding widespread applications within many areas of chemistry. For their light-induced processes, the generally accepted picture is that all function emanates from triplet states because the singlet states initially prepared by light absorption are depopulated via intersystem crossing on the 100-fs time scale, before they are significantly involved in c

In this work, a numerical study has been performed to simulate the unsteady fluid flow and heat transfer in a transonic high-pressure turbine stage. The main objective of this study is to understand the unsteady flow field and heat transfer in a single transonic turbine stage using an unsteady structured Navier-Stokes solver. For the time accurate computation, a fully implicit time discretization,

Rat bladder hypertrophy, induced by a partial ligation of the urethra, was used to study the accompanying changes of microvascular smooth muscle mechanics, pharmacology and morphology. A segment of a microarterial vessel to the bladder was taken from a defined anatomical location and studied in a wire myograph in vitro at the length for maximal isometric force development (Lmax). After 10 days of

A method for analysing the influence of profile errors upon load-sharing capabilities and mesh stiffness of spur gears is proposed. The analysis is based upon a static, two-dimensional finite element approach. The contacts between mating gear teeth are identified in the deformed state, and the nodal point density permits contact pressure distribution emulation for moderate to high load levels. In

Treatment of [Ru-3(CO)(10)(mu-dppm)] (4) [dppm = bis(diphenylphosphido)methane] with tetramethylthiourea at 66 degrees C gave the previously reported dihydrido triruthenium cluster [Ru-3(mu-H)(2)(mu(3)-S)(CO)(7)(mu-dppm)] (5) and the new compounds [Ru-3(mu(3)-S)(2)(CO)(7)(mu-dppm)] (6), [Ru-3(mu(3)-S)(CO)(7)(mu(3)-CO)(mu-dppm)] (7) and [Ru-3(mu 3-S)eta(I)-C(NMe2)(2)}(CO)(6)(mu(3)-CO)(mu-dppm)] (8)

We have shown that protein kinase C (PKC)epsilon, independently of the catalytic domain, induces outgrowth of cellular processes via its regulatory domain in both neural cells and fibroblasts. This was accompanied by stress fibre loss. Here, we have examined the role of the small GTPases, Rac1, and Cdc42, in these PKC-mediated morphological and cytoskeletal changes. Both constitutively active and

The Spaniard Alfonso, Bishop of Jaén, was commissioned by St. Bridget of Sweden to prepare an edition of her Revelationes (the Liber Celestis). The present book gives an account of Alfonso's life and critical editions of three writings by him.

We have investigated the effects of hilar denervation of rat liver upon the activity of hepatic lipase determined in tissue extracts. Denervated animals had an enzyme activity of 7.89 +/- 0.37 mU/mg protein, compared to 6.45 +/- 0.43 in sham-operated controls (mean +/- S.E.; P less than 0.05). We conclude that hepatic innervation may contribute to the regulation of hepatic lipase activity.

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Combined quantum chemical and molecular mechanics geometry optimisations have been performed on myoglobin without or with O(2) or CO bound to the haem group. The results show that the distal histidine residue is protonated on the N(varepsilon2) atom and forms a hydrogen bond to the haem ligand both in the O(2) and the CO complexes. We have also re-refined the crystal structure of CO-myoglobin by a

In light of the increased interest in small scale dosimetry, this paper presents a quantitative autoradiographic method for evaluation of heterogeneous activity distribution in tissues. This was studied in rat tissues after administration of 111In-chloride, -oxine, -tropolone, 111In-labeled homologous blood cells and 111In-anti-CEA-F(ab')2, using quantitative whole-body autoradiography. Quantifica