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Several approaches to treat laminin alpha 2 chain-deficient congenital muscular dystrophy (MDC1A) in mouse models have been undertaken. Most have shown promising results in young animals. However, older animals have only been characterized to some extent. Herein we analyze the lifespan of laminin alpha 2 chain deficient mice with transgenic overexpression of laminin alpha 1 chain. Further outcome

Digital assessments of caput succedaneum are subjective; however, caput succedaneum can also be expressed as ultrasound measured skin-skull distance (SSD). In this study, we aimed to compare the clinical and ultrasound assessment of caput succedaneum (caput) in nulliparous women in the first stage of labour. Furthermore, we aimed to investigate the repeatability of ultrasound measurements. We obse

This paper deals with geographical and organizational patterns of knowledge flows in the media industry of southern Sweden, an industry that is characterized by a strong ?symbolic? knowledge base. The aim is to address the question of the local versus the non-local as the prime arena for knowledge exchange, and to examine the organizational patterns of knowledge sourcing with specific attention pa

Access to a quiet side in one's dwelling is thought to compensate for higher noise levels at the most exposed façade. It has also been indicated that noise from combined traffic sources causes more noise annoyance than equal average levels from either road traffic or railway noise separately.

Production of heavy photons (Drell-Yan), gauge bosons, Higgs bosons, and heavy flavors, which is treated within the QCD parton model as a result of hard parton-parton collision, can be considered a bremsstrahlung process in the target rest frame. In this review, we discuss the basic features of the diffractive channels of these processes in the framework of color dipole approach. The main observat

To explore the catalytic properties of cobalt oxide at the atomic level, we have studied the interaction of CO and O-2 with well-ordered Co3O4(111) thin films using scanning tunneling microscopy (STM), high-resolution X-ray photoelectron spectroscopy (HR-XPS), infrared reflection absorption spectroscopy (IRAS), and temperature-programmed desorption spectroscopy (TPD) under ultrahigh vacuum (UHV) c

We propose a method of reducing the switching noise in the substrate of an integrated circuit. The main idea is to design the digital circuits to obtain a periodic supply current with the same period as the clock. This property locates the frequency components of the switching noise above the clock frequency. Differential return-to-zero signaling is used to reduce the data-dependency of the curren

Amide hydrogen exchange (HX) is widely used in protein biophysics even though our ignorance about the HX mechanism makes data interpretation imprecise. Notably, the open exchange-competent conformational state has not been identified. Based on analysis of an ultralong molecular dynamics trajectory of the protein BPTI, we propose that the open (O) states for amides that exchange by subglobal fluctu

Detailed knowledge on habitat requirements is a key to successful conservation actions. The marbled jewel beetle Poecilonota variolosa (Buprestidae) has a wide global distribution but populations are often scarce and typically fragmented. In Sweden it is monophagous on aspen Populus tremula and is classified as near threatened on the Swedish Red List due to its rapid population decline. This study

The effect of disperse phase volume fraction on the turbulence in a scale model of a high-pressure homogenizer was studied experimentally. Velocity fields of the continuous phase were measured using particle image velocimetry. Refractive index matching combined with digital filtering enabled measurement with disperse phase present. Geometry and physical properties were carefully scaled in order to

CUB and Sushi multiple domains 1 (CSMD1) is a transmembrane protein containing 15 consecutive complement control protein (CCP) domains, which are characteristic for complement inhibitors. We expressed a membrane-bound fragment of human CSMD1 composed of the 15 C-terminal CCP domains and demonstrated that it inhibits deposition of C3b by the classical pathway on the surface of Chinese hamster ovary

ABSTRACT Background: The prescription of antidepressants in nursing homes has increased markedly since the introduction of SSRIs, while at the same time depressive symptoms often go unrecognized and untreated. The aim of this study was to examine whether depression among residents in nursing homes is treated adequately. Methods: A sample of 429 participants from 11 Swedish nursing homes was select

International Relations (IR) research is constantly undergoing change, both in reaction to real changes in international politics and to new patterns of and trends in cooperation and conflict, as well as to methodological innovations within the academy. In general the discipline of IR has paid extensive attention to the definition and dynamics of conflict, while in comparison fewer efforts have be

We describe the new microsporidium Hamiltosporidium tvaerminnensis gen. et sp. nov. with an emphasis on its ultrastructural characteristics and phylogenetic position as inferred from the sequence data of SSU rDNA, alpha-and beta-tubulin. This parasite was previously identified as Octosporea bayeri Jirovec, 1936 and has become a model system to study the ecology, epidemiology, evolution and genomic

Purpose This study aims to report the clinical outcome of computer-assisted fundoplication (CAF) in children. Methods As our center changed policy to using computer-assisted surgery only, a prospectively studied cohort of 40 children underwent CAF, during the period from January 2006 through May 2013. The collected data include patient demographics and postoperative complications as well as medica

Pore formation and pore closure in poly(D,L-lactide-co-glycolide)-based drug delivery systems are two important processes as they control the release of the encapsulated drug. The phenomenon pore closure was investigated by studying the effects of the pH and the temperature of the release medium, and the properties of the polymer. Poly(D,L-lactide-co-glycolide) (PLG) films were subjected to a pore

To determine the frequency of each American College of Rheumatology (ACR) criterion met at time of enrollment, and the increase in each of the criteria over 5 years.

In this article, researchers evaluate the empirical performance of the Mincer earnings equation, which has been the benchmark model for assessment of wage profiles since 1974. The analysis concerns workers in the manufacturing industry in three countries before 1900. The Mincer equation must be adjusted with respect to functional form in order to capture the wage profiles of past industrial worker

The origin and biological role of dynamic motions of folded enzymes is not yet fully understood. In this study, we examine the molecular determinants for the dynamic motions within the beta-barrel of superoxide dismutase 1 (SOD1), which previously were implicated in allosteric regulation of protein maturation and also pathological misfolding in the neurodegenerative disease amyotrophic lateral scl

Classically, Parkinson's disease (PD) is linked to dopamine neuron death in the substantia nigra pars compacta. Intracytoplasmic protein inclusions named Lewy bodies, and corresponding Lewy neurites found in neuronal processes, are also key features of the degenerative process in the substantia nigra. The molecular mechanisms by which substantia nigra dopamine neurons die and whether the Lewy path