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Abstract Work on the design, synthesis, and biological evaluation of galectin inhibitors is presented. The most significant results relate to the development of galactose-based arginine “tweezers” and taloside-based galectin inhibitors. The galectins are a β-galactoside binding protein family. They are involved in cancer and inflammation, thus comprising interesting pharmaceutical targets. Galact

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Roman glass from indigenous sites is a key source material for studying the impact of Rome on Iron Age Scotland, but it has never been properly studied. This work fills that gap. This study is based on the Roman glass vessels found on non-Roman/native sites north of Hadrian’s Wall, dated mainly to the Roman Iron Age (AD 10-400 AD). These often-overlooked broken sherds of glass are shown to be pa

Popular Abstract in Swedish Syftet med denna avhandling var att undersöka olika aspekter på intersubjektivitet, metakognitiv utveckling och mellanmänsklig förståelse. Mer precist var syftet att undersöka hur några specifika teorier – mentaliseringsteorin, teorin om primär intersubjektivitet, samt interaktionsteorin – beskriver vilken roll intersubjektivitet har att spela i denna utveckling. De förThe aim of the thesis was to examine different aspects of the role of intersubjectivity in metacognitive development and in social understanding. More specifically, it investigates how different theoretical frameworks, such as mentalization theory, the theory of primary intersubjectivity, and interaction theory describe the developmental role of intersubjectivity. The suggestions these theories ma

Popular Abstract in Swedish Lera-vatten-systemet finns i stort sett överallt i vår omgivning. Syftet med denna avhandling är att identifiera och undersöka egenskaper hos leror som är av betydelse för deras inbördes växelverkan. Leror är sammansatta av två eller tre molekylära lager och får därför en relativt komplex fördelning av elektrostatiska laddningar. Denna fördelning förändras med olika betClays are the world’s most widely used natural material, however, little is known regarding the microstructure as well as the forces involved in clay-water interactions, and their influence on the swelling properties. The utilization of clay platelets is nowadays a key in a number of biological and industrial applications e.g. nuclear waste management. Bentonites from different natural sources an

We study deterministic algorithms for gossiping problem in ad hoc radio networks. The gossiping problem is a communication task in which each node of the network possesses a unique single message that is to be communicated to all other nodes in the network. The efficiency of a communication algorithm in radio networks is very often expressed in terms of: max-eccentricity D, max-indegree Δ, and siz

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A very large majority of the current product development process models put forward in textbooks present a homogenous structure, what Ulrich & Eppinger [1] call the market-pull model, presented as a generic one, while other possible product development process models are merely seen as variants. This paper focuses on the task clarification and derived activities (mainly the systematic search f

We present a PropBank semantic role labeling system for English that is integrated with a dependency parser. To tackle the problem of joint syntactic-semantic analysis, the system relies on a syntactic and a semantic subcomponent. The syntactic model is a projective parser using pseudo-projective transformations, and the semantic model uses global inference mechanisms on top of a pipeline of class