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A recombinant Baeyer-Villiger monooxygenase, BVMO4 from Dietzia sp. D5 has been previously reported. The enzyme exhibited good thermostability and was active with a wide range of cyclic ketone substrates but catalysed poorly the conversion of cyclohexanone to caprolactone. The present work focuses on protein engineering of BVMO4 to improve the conversion of cyclohexanone. Thus, a structural model

Purpose: The objective was to assess the reliability level of mini-plate fixation used in fracture mandibles in order to evaluate the structure stability in both convalescence and healing periods. Methods: In the convalescence period, the failure scenario is measured by the relative displacement between two fracture surfaces which should not exceed an acceptable value in order to obtain a good sta

The present numerical study aims to assess the performance of an Eulerian Stochastic Field (ESF) model in simulating spray flames produced by three fuel injectors with different nozzle diameters of 100 μm, 180 μm and 363 μm. A comparison to the measurements shows that although the simulated ignition delay times are consistently overestimated, the relative differences remain below 28%. Furthermore,

Deoxyadenosine kinase from Dictyostelium discoideum (DddAK) phosphorylates its natural substrate (2’-deoxyadenosine, dAdo) as well as the arabinosyladenine analogues vidarabine (araA) and fludarabine (F-araA) to their corresponding 5’-monophosphates. DddAK has been here immobilized by ionic interaction on an aminated epoxy-functionalized support (SepabeadsTM EC-EP), and cross-linked with oxidized

In this work, a carbon felt electrode (CFE) was modified with a multiwalled carbon nanotube-gold-platinum (MWCNT-Au-Pt) hybrid nanomaterial and integrated with an osmium redox polymer (OsRP, [Os(2, 2’-bipyridine)2(poly-vinylimidazole)10Cl]Cl) and Gluconobacter oxydans DSM 2343 (G. oxydans) cells. The developed electrode was used as the bioanode in a 5.0 mM K3Fe(CN)6mediator containing phosphate bu

Hydrogen, carbon, and oxygen are common unintentional impurities of Al(x)Ga(1−x)N crystals. This impurity structure and its interplay with Mg impurities in Al(x)Ga(1−x)N semiconductors are relevant to develop the p-type nitride crystals for various devices (e.g, LEDs, transistors, gas sensors) but are still unclear. Here we have investigated Mg-doped Al0.5Ga0.5N before and after postgrowth anneali

IntroductionThis contribution presents recent research results on segmental andsuprasegmental cues to word-internal and sentence-level structure. InSwedish, prosody is tightly connected to morphological and syntacticstructure. For example, every word stem is pronounced with either a low or ahigh tone. The stem tone depends on what follows the stem. Thus, if asingular suffix is connected to the wor

In this thesis, acoustofluidics has been used to process blood samples as a sample preparation step prior to biomarker detection. This is often required as the large amount of blood cells otherwise can interfere with the detection method. Acoustofluidics means moving particles or cells with acoustic forces within microfluidic channels. Ultrasound is used to create a standing wave between the chann

Över 30 år av forskning inom tungjonsfysik, Quantum ChromoDymanics (QCD) och kosmologi har etablerat vår nuvarande syn på universums tidigare stadie: kort efter Big Bang var universum fyllt av ett mycket hett och kompakt medium bestående av fria kvarkar och gluoner, den så kallade Kvarkgluon plasman (Quark--Gluon Plasma, QGP). Detta medium expanderade snabbt, och kyldes ner tills beståndsdelarnas This study reports on identified hadron production as a function of event multiplicity (dNch/dη) and transverse spherocity (SO) in proton-proton collisions at √s = 7 and 13 TeV measured with the ALICE detector at the LHC. The particle spectra and their ratios measured in high-multiplicity events show signatures of an expanding medium. Integrated particle yields as a function of multiplicity measur

In this thesis, we model stochastic processes in time and space. We focus on the processes whose covariance structure is either changing over the time span, or depends on the location in space. We develop models that appropriately describe and analyze such data behaviors in various different fields including finance, economics and engineering. This thesis begins with an introductory section which

This paper provides exact analysis of a model for sustainable control of a one-warehouse-N-retailer inventory system with time based shipment consolidation. The model is motivated by discussions with industry, and involves the possibility to reserve intermodal transportation capacity in combination with truck transports available on demand. Inventories are reviewed continuously while shipments fro

Objective: The individual enabling and support (IES) model was effective in gaining competitive employment for people with affective disorders compared with traditional vocational rehabilitation (TVR) services in a randomized controlled trial in a Swedish setting. The object of this study is to perform a cost-effectiveness analysis of IES comparing to TVR. Methods: We considered the costs of inter

Aim: Target temperature management (TTM) at 32-36 °C is recommended in unconscious survivors of cardiac arrest. This study reports awakening in the TTM-trial. Our predefined hypotheses were that time until awakening correlates with long-term neurological outcome and is not affected by level of TTM. Methods: Post-hoc analysis of time until awakening after cardiac arrest, its association with long-t

Background: Person-centred care (PCC) is considered a key component of effective illness management and high-quality care. However, the PCC concept is underdeveloped in outpatient care. In rheumatology, PCC is considered an unmet need and its further development and evaluation is of high priority. The aim of the present study was to conceptualize and operationalize PCC, in order to develop an inst