The recent demostration that neurons for transplantation can be generated from stem cells and that the adult brain produces new neurons in response to stroke has raised hope for the development of a stem cell therapy for patients affected with this disorder. In this review we propose a road map to the clinic and describe the different scientific tasks that need to be accomplished to move stem cell

The avian circadian and visual systems are integrally related and together influence many aspects of birds' behavior and physiology. Certainly, light cycles and their visual perception are the major zeitgebers for circadian rhythms, but do circadian rhythms affect vision? To assess whether visual func-tion is regulated on a circadian basis, flash-evoked electroretinograms (ERGs) and vision-evoked

A Swedish family with two generations suffering from presenile dementia with an unusually severe Alzheimer encephalopathy was first reported in 1946. The hypothesis that the disease was inherited through a dominant gene is strongly supported by the follow-up 50years later of three additional generations and molecular genetic findings of a novel presenilin-1 gene mutation in the family. The pedigre

A relativistic extension is made of methods by which intermediate coupling amplitudes are deduced from measured energy levels and combined with measured lifetimes to obtain transition probabilities within a multiplet between two pure configurations. A procedure for incorporating the relativistic j-dependence of the radial transition integral into the empirical data reduction is presented and appli

Objective-Recent studies failed to show long-term benefit with low-molecular weight heparins (LMWH) in unstable coronary heart disease. A previous study of vascular effects of the cytostatic agent 5-fluorouracil (5-FU) showed that dalteparin prevented thrombosis induced by 5-FU but endothelial damage was not ameliorated and was present also in animals treated with dalteparin only. This study inves

A purified 75-kDa myrosinase and a crude rapeseed myrosinase fraction were used as antigens to produce mouse anti-myrosinase monoclonal antibodies. The 75-kDa myrosinase was also used to produce a polyclonal rabbit antiserum. The antiserum and one monoclonal antibody reacted with three distinct rapeseed polypeptides of 75, 70 and 65 kDa (M75, M70 and M65, respectively). A second set of monoclonal

Following a brief account of the main events in the life of Rāmānuja according to traditional hagiographical works, the article examines the fundamental exegetical, epistemological, ontological and soteriological positions of this medieval thinker. These views are contrasted mainly with those of the greatly influential Śaṅkara some centuries earlier, particularly with respect to the conflict betwe

The hydration (or solvation) of the lithium, sodium, fluoride, and chloride ions are investigated using a combined quantum chemical statistical mechanical model. Radial distribution functions and the distribution of coordination numbers are reported and compared with other recent studies. An algorithm to investigate the geometry of the first solvation shell is proposed and applied to the four hydr

Denna rapport utgör andra delen av en undersökning om sjukgymnastutbildningen vid Lunds universitet. I en tidigare alumnundersökning har sjukgymnaster med 4-5 års yrkeserfarenhet uttalet sig om hur utbildningen motsvarar yrkeslivets krav (Höglund, Nilsson Lindström 2003). För att vidga arbetslivsperspektivet består denna andra del av en avnämarundersökning av presumtiva arbetsgivare som statliga m

Popular Abstract in Swedish Innovation är ryggraden i en fungerande marknadsekonomi. Det är genom innovationer som nationer, industrisektorer och företag konkurrerar. Det sker mycket både internationellt och nationellt som påverkar den svenska byggsektorn, vilket både ställer krav och skapar möjlighet för sektorn att förändras. Forskning kring innovationer i byggandet har mött ett ökat intresse deInnovation and development are the backbone of a thriving market economy. It is through innovations of various kinds that nations, industries and companies compete. Many actions in areas internationally and nationally will affect the construction sector. Research into construction innovation has attracted increasing interest. There have been studies ranging from how national research policies supp

Interactions of adenosine 3':5'-cyclic monophosphate (cAMP) and N-6,2'-O-dibutyryl-adenosine 3':5'-cyclic monophosphate (dbcAMP) with a lipid layer composed of monoolein-based preparation and dioleoyl phosphatidylcholine ( DOPC) were investigated by small-angle X-ray diffraction (SAXD) and Raman spectroscopy. The reversed hexagonal (H-II) MO/DOPC/H2O phase of 65:15:20 wt.% composition was selected

Bacillus subtilis ferrochelatase (EC 4.99.1.1), the final enzyme in protoheme IX biosynthesis, was produced with an inducible T7 RNA polymerase expression system in Escherichia coli and purified from the soluble cell fraction. It was crystallized from polyethylene glycol solution using the microseeding technique. The crystals diffract to a minimum Bragg spacing of 2.1 A. The space group is P4(2) w

Even before the discovery of X-rays in 1895 attempts were being made to classify the joint destruction that occurs in hemophilic arthropathy. The advent of radiography added impetus to the search for the optimum classification system. Subsequent attempts have included advanced imaging methods, especially magnetic resonance imaging (MRI). Because of its high spatial resolution and ability to Visual

Background and Purpose-We have previously shown that delivery of brain-derived neurotrophic factor (BDNF) through direct intrahippocampal gene transduction with a viral vector suppresses the formation of new dentate granule cells triggered by global forebrain ischemia. Here, we investigated whether inhibition of endogenous BDNF alters ischemia-induced neurogenesis in the dentate gyrus. Methods-Rat