OBJECTIVE:: The risk factor pattern underlying a parental history of myocardial infarction (MI) is incompletely understood. We examined whether a parental history of clinically verified early MI may promote development of insulin resistance, obesity and the metabolic syndrome (MetS). METHODS:: One hundred and seventy-four offspring to patients with clinically verified MI before 60 years of age i

Nuclear quadrupole resonance (NQR) is a radio frequency (RF) spectroscopic technique, allowing the detection of many high explosives and narcotics. In practice, NQR is restricted by the low signal-to-noise ratio of the observed signals, a problem further exacerbated by the presence of strong RF interference (RFI). The current literature focuses on the use of conventional, multiple-pulsed NQR (cNQR

Although brain tumors are classified and treated based upon their histology, the molecular factors involved in the development of various tumor types remain unknown. In this study, we show that the type and order of genetic events directs the development of gliomas, central nervous system primitive neuroectodermal tumors, and atypical teratoid/rhabdoid-like tumors from postnatal mouse neural stem/

Variants in the TCF7L2 gene (transcription factor 7-like 2) have shown strong association with type 2 diabetes with two defined risk haplotypes, HapA and HapB(T2D). TCF7L2 may play a role in both glucose homeostasis and adipogenesis. Our aim was to characterize the TCF7L2 mRNA expression and regulation in human adipose tissue. We quantified TCF7L2 mRNA levels in cultured human adipocytes and in bi

Abstract in Italian Arthur Prior (1914-1969) si è occupato di temi che spaziano dalla logica formale all'etica, ed ha fornito contributi di grandissima importanza soprattutto nell'ambito della logica modale, della metafisica, e della filosofia del tempo. E' considerato il padre della logica temporale e il precursore della contemporanea logica ibrida, è stato un precursore della semantica a mondi p

Quantitative magnetic resonance imaging (MRI)-based biomarkers, which capture physiological and functional tumor processes, were evaluated as imaging surrogates of early tumor response following chemoradiotherapy in glioma patients. A multiparametric extension of a voxel-based analysis, referred as the parametric response map (PRM), was applied to quantitative MRI maps to test the predictive poten

Objectives: Sonoclot was used in this study to monitor low molecular weight heparin (LMWH) during haemodialysis. Material and Methods: Two different intravenous doses (standard / half-dose) of dalteparin were studied in eight patients. Blood was sampled for coagulation analyses with Sonoclot, thrombin-antithrombin (TAT) and anti-Xa. A visual fibrin deposition score (VFS) in the venous drip chamber

Dynamics of commercial fish stocks are generally associated with fishing pressure and climate variability. Due to short time series, past studies of the relationships between fish stock dynamics and climate have mainly been restricted to the last few decades. Here we analyzed a century-long time series of plaice, cod and haddock from the Skagerrak-Kattegat, to assess the long-term influence of cli

Artikeln diskuterar en väsentligen nordamerikansk tanketradition som explicit eller implicit framställer den centrala antika filosofiska frågan – ”hur bör jag leva?” – som sin frågehorisont, och som gör det såväl teoretiskt, empiriskt som normativt. Det handlar om sociologer och andra samhällsvetare, men också om litteraturvetare och kulturkritiker, essäister och skönlitterära författare. ArtikelnThe article describes and analyses an essentially American intellectual tradition which explicitly or implicitly poses the central question of Hellenistic and Roman philosophy – ”how should I live?” – as its main theme and concern, and which discusses the matter theoretically, empirically, and normatively. The tradition includes sociologists and other social scientists, but also cultural theorists