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Quantitative Time-Resolved Fluorescence Imaging of Androgen Receptor and Prostate-Specific Antigen in Prostate Tissue Sections
Androgen receptor (AR) and prostate-specific antigen (PSA) are expressed in the prostate and are involved in prostate cancer (PCa). The aim of this study was to develop reliable protocols for reproducible quantification of AR and PSA in benign and malignant prostate tissue using time-resolved fluorescence (TRF) imaging techniques. AR and PSA were detected with TRF in tissue microarrays from 91 PCa
Changes in expression of genes representing key biologic processes after neoadjuvant chemotherapy in breast cancer, and prognostic implications in residual disease
Purpose: The primary aim was to derive evidence for or against the clinical importance of several biologic processes in patients treated with neoadjuvant chemotherapy (NAC) by assessing expression of selected genes with prior implications in prognosis or treatment resistance. The secondary aim was to determine the prognostic impact in residual disease of the genes' expression. Experimental Design:
A Self-Reconfiguring IEEE 1687 Network for Fault Monitoring
Efficient handling of faults during operation is highly dependent on the interval (latency) from the time embedded instruments detect errors to the time when the fault manager localizes the errors. In this paper, we propose a self-reconfiguring IEEE 1687 network in which all instruments that have detected errors are automatically included in the scan path. To enable self-reconfiguration, we propos
Towards Grading Gleason Score using Generically Trained Deep convolutional Neural Networks
We developed an automatic algorithm with the purpose to assist pathologists to report Gleason score on malignant prostatic adenocarcinoma specimen. In order to detect and classify the cancerous tissue, a deep convolutional neural network that had been pre-trained on a large set of photographic images was used. A specific aim was to support intuitive interaction with the result, to let pathologists
Practical Applications Summary: Regime-Based versus Static Asset Allocation: Letting the Data Speak
Regime shifts present a big challenge to traditional strategic asset allocation. This article investigates whether regimebased asset allocation can effectively respond to changes in financial regimes at the portfolio level, in an effort to provide better long-term results than more static approaches can offer. The authors center their regime-based approach around a regime-switching model with time
Multiplex cytokine analyses in patients with rheumatoid arthritis require use of agents blocking heterophilic antibody activity
Objectives: Heterophilic antibodies, such as rheumatoid factor (RF), are known to interfere with enzyme-linked immunosorbent assays (ELISAs). Treatment of rheumatoid arthritis (RA) with tumour necrosis factor (TNF)-α blockers is well established. The aims of this study were to develop a protocol for blocking the interaction of present heterophilic antibodies and to validate this procedure by evalu
Fetal scalp blood lactate during second stage of labor : determination of reference values and impact of obstetrical interventions
Objective: To determine the reference interval of fetal scalp blood lactate during second stage of labor. Material: Two hundred and fifty-three women in first stage of labor with a reassuring CTG were asked for permission to sample fetal scalp blood during second stage. Results: In cases with reassuring CTG and five minute Apgar score ≥9, the mean lactate value (±2 SD) was 2.5 mmol/L (lower limit
Hip fracture, mortality risk, and cause of death over two decades
Summary: Men and women with hip fracture have higher short-term mortality. This study investigated mortality risk over two decades post-fracture; excess mortality remained high in women up to 10 years and in men up to 20 years. Cardiovascular disease (CVD) and pneumonia were leading causes of death with a long-term doubling of risk. Introduction: Hip fractures are associated with increased mortali
Gestational diabetes : what’s up?
Health Care Students’ Attitudes Towards Working with Sexual Health in Their Professional Roles : Survey of Students at Nursing, Physiotherapy and Occupational Therapy Programmes
The aim of this study was to explore differences and similarities in health care students’ attitudes towards working with and communicating with patients about sexual health issues in their future professions. The aim was also to explore whether the students’ gender, age and future professions were influencing factors and whether there was a change in attitude depending on educational levels, gend
Seeing through the interface : Poly(ε-Caprolactone) surface modification of poly(glycerol-co-sebacic acid) membranes in adult porcine retinal explants
The purpose of this study was to investigate the adhesion properties and tissue reactions in an in vitro model of nanofabricated membranes emulating the vitreous cortex. Electrospinning was performed for either 5, 10 or 15 min to create various thicknesses of poly(ε-caprolactone) (PCL) fibre mats on a poly(glycerol-co-sebacic acid) (PGS) surface. These were fused with adult porcine retinal explant
Validering av svenska melanom-registret visar liten felregistrering : Inkomplett för 4 procent av patienterna vid sentinel node-diagnostik
Registers of quality can be used to ensure that health care recommendations are followed, to verify the logistics of care and serve as a basis for research when population based data are needed. Validation of quality is important and is the fundament of accurate interpretation of collected data. In the present validation of sentinel node biopsy (SN) for malignant melanoma in Southern Sweden during
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Objective: The main goal of this research was to assess the seroprevalence of antibodies against measles, rubella, mumps, hepatitis B and all three poliovirus serotypes among children in the Quindio Department, Colombia. Methods: Blood samples were obtained from 170 healthy children aged 5-9 years from nine municipalities in Quindio. The presence of serum IgG antibodies against measles, rubella, m
Introduction : Performativity in Literature. The Lund–Nanjing Seminars
The seventeen papers were originally discussed in joint seminars in Lund and Nanjing in the beginning of 2014, and presented at a conference in Stockholm in October 2014.
Screening for Prostate Cancer Starting at Age 50-54 Years. A Population-based Cohort Study
Background: Current prostate cancer screening guidelines conflict with respect to the age at which to initiate screening. Objective: To evaluate the effect of prostate-specific antigen (PSA) screening versus zero screening, starting at age 50-54 yr, on prostate cancer mortality. Design, setting, and participants: This is a population-based cohort study comparing 3479 men aged 50 yr through 54 yr r
Practical Aspects of Performance Theory in Literary Studies
Adipose-derived Stem Cells Counteract Urethral Stricture Formation in Rats
Background: A medical treatment for urethral stricture (US) is not yet available. Objective: To evaluate if local injection of human adipose tissue-derived stem cells (hADSC) prevents urethral fibrosis in a rat model of US. Design, setting, and participants: Male rats were divided into three groups: sham, US, and hADSC (n = 12 each). Sham rats received a vehicle injection in the urethral wall. US
Novel engineered peptides of a phage lysin as effective antimicrobials against multidrug-resistant Acinetobacter baumannii
Acinetobacter baumannii is a Gram-negative bacterial pathogen responsible for a range of nosocomial infections. The recent rise and spread of multidrug-resistant A. baumannii clones has fueled a search for alternative therapies, including bacteriophage endolysins with potent antibacterial activities. A common feature of these lysins is the presence of a highly positively charged C-terminal domain