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Structural insights into eukaryotic aquaporin regulation

Aquaporin-mediated water transport across cellular membranes is an ancient, ubiquitous mechanism within cell biology. This family of integral membrane proteins includes both water selective pores (aquaporins) and transport facilitators of other small molecules such as glycerol and urea (aquaglyceroporins). Eukaryotic aquaporins are frequently regulated post-translationally by gating, whereby the r

Sustainability framings of accommodation sharing

The existing research often overlooks the fact that accommodation sharing is not a homogeneous sector but comprises rental, reciprocal and free platforms. This paper aims to compare sustainability narratives held by operators and users of the three platform types with the narratives identified in the literature. First, drawing on framing theory, environmental, economic and social framings of accom

Technology Management: a cross-disciplinary master program with a focus on Leadership

Leadership is important. Management is important. However, leadership and management is not the same thing, in fact they are fundamentally different. In a cross disciplinary master programme named Technology Management at Lund University, Sweden, the students are given opportunities to study and learn management, however, what makes the program unique is its profound focus on leadership. The Techn

On using games for practicing entrepreneurial mindset

Today, innovation and entrepreneurship are key words for many universities, as it constitutes an important part of most universities’ public and scientific outreach task. Universities are striving to increase the number of innovations and entrepreneurs generated by the university. Teaching and learning entrepreneurship is therefore of importance and schools, colleges and universities can play an i

Stabilities of Platinum(II) Chloro and Bromo Complexes and Kinetics for Anation of the Tetraaquaplatinum(II) ion by Halides and Thiocyanate

The anations of Pt(H2O)42+ and PtX(H2O)3+ (to trans-PtX(H2O)2) by X− = Cl−, Br−, I− and SCN− and the anation of trans-PtX2(H2O)2) by X− = Cl−, Br− and I− have been studied at 25 °C and 1.00 M perchlorate medium using both stopped-flow and conventional spectrophotometry. For large excess of X−, PtX42− is formed according to the mechanism in Figure 1. The results indicate an entering ligand order ofThe anations of Pt(H2O)42+ and PtX(H2O)3+ (to trans-PtX(H2O)2) by X− = Cl−, Br−, I− and SCN− and the anation of trans-PtX2(H2O)2) by X− = Cl−, Br− and I− have been studied at 25 °C and 1.00 M perchlorate medium using both stopped-flow and conventional spectrophotometry. For large excess of X−, PtX42− is formed according to the mechanism in Figure 1. The results indicate an entering ligand order of

EVERREST prospective study : A 6-year prospective study to define the clinical and biological characteristics of pregnancies affected by severe early onset fetal growth restriction

Background: Fetal growth restriction (FGR) is a serious obstetric condition for which there is currently no treatment. The EVERREST Prospective Study has been designed to characterise the natural history of pregnancies affected by severe early onset FGR and establish a well phenotyped bio-bank. The findings will provide up-to-date information for clinicians and patients and inform the design and c

Tracer particles in two-dimensional elastic networks diffuse logarithmically slow

Several experiments on tagged molecules or particles in living systems suggest that they move anomalously slow - their mean squared displacement (MSD) increase slower than linearly with time. Leading models aimed at understanding these experiments predict that the MSD grows as a power law with a growth exponent that is smaller than unity. However, in some experiments the growth is so slow (fitted

Leading chiral logarithms for the nucleon mass

We give a short introduction to the calculation of the leading chiral logarithms, and present the results of the recent evaluation of the LLog series for the nucleon mass within the heavy baryon theory. The presented results are the first example of LLog calculation in the nucleon ChPT. We also discuss some regularities observed in the leading logarithmical series for nucleon mass.

Sex-specific outcomes with addition of defibrillation to resynchronisation therapy in patients with heart failure

Objective Among primary prevention patients with heart failure receiving cardiac resynchronisation therapy (CRT), the impact of additional implantable cardioverter defibrillator (ICD) treatment on outcomes and its interaction with sex remains uncertain. We aim to assess whether the addition of the ICD functionality to CRT devices offers a more pronounced survival benefit in men compared with women

Lieb–Thirring Inequalities for Finite and Infinite Gap Jacobi Matrices

We establish Lieb–Thirring power bounds on discrete eigenvalues of Jacobi operators for Schatten class perturbations under very general assumptions. Our results apply, in particular, to perturbations of reflectionless Jacobi operators with finite gap and Cantor-type essential spectrum.

Time-Continuous Quasi-Monte Carlo Ray Tracing

Domain-continuous visibility determination algorithms have proved to be very efficient at reducing noise otherwise prevalent in stochastic sampling. Even though they come with an increased overhead in terms of geometrical tests and visibility information management, their analytical nature provides such a rich integral that the pay-off is often worth it. This paper presents a time-continuous, prim

Berättelsen om spegelbilden : det höviska och det narrativa begäret

Detta är en monografi som förenar den filologiska disciplinens traditionella infallsvinklar (textedition, översättning, litterära och lingvistiska analyser) med modern litteraturteori. Boken ingår i Ellerströms akademiska serie Eureka och innehåller en kritisk textedition av den fornfranska berättelsen Li Lais de l’ombre av Jean Renart (962 verser). Texten är etablerad med utgångspunkt i ett av de

På lavexkursion längs Indalsälven.

Sveriges Lichenologiska Förening (SLF) gör årligen två exkursioner, där den höstliga ofta går till den norra halvan av landet. Den 12-13 september 2015 exkurerade vi längs den jämtländska delen av Indals-älven.

Iconic photographs and the ebb and flow of empathic response to humanitarian disasters

The power of visual imagery is well known, enshrined in such familiar sayings as "seeing is believing" and "a picture is worth a thousand words." Iconic photos stir our emotions and transform our perspectives about life and the world in which we live. On September 2, 2015, photographs of a young Syrian child, Aylan Kurdi, lying face-down on a Turkish beach, filled the front pages of newspapers wor

Gαolf mutation allows parsing the role of cAMP-dependent and extracellular signal-regulated kinase-dependent signaling in l-3,4-dihydroxyphenylalanine-induced dyskinesia

Although l-3,4-dihydroxyphenylalanine (l-DOPA) remains the reference treatment of Parkinson's disease, its long-term beneficial effects are hindered by l-DOPA-induced dyskinesia (LID). In the dopamine (DA)-denervated striatum, l-DOPA activates DA D1 receptor (D1R) signaling, including cAMP-dependent protein kinase A (PKA) and extracellular signal-regulated kinase (ERK), two responses associated wi

Convulsant doses of a dopamine D1 receptor agonist result in erk-dependent increases in Zif268 and Arc/Arg3.1 expression in mouse dentate gyrus

Activation of dopamine D1 receptors (D1Rs) has been shown to induce epileptiform activity. We studied the molecular changes occurring in the hippocampus in response to the administration of the D1-type receptor agonist, SKF 81297. SKF 81297 at 2.5 and 5.0 mg/kg induced behavioural seizures. Electrophysiological recordings in the dentate gyrus revealed the presence of epileptiform discharges peakin

Extracellular signal-regulated kinase activation is required for consolidation and reconsolidation of memory at an early stage of ontogenesis

The ability to form long-term memories exists very early during ontogeny; however, the properties of early memory processes, brain structures involved and underlying cellular mechanisms are poorly defined. Here, we examine the role of extracellular signal-regulated kinase (ERK), a member of the mitogen-activated protein kinase/ERK signaling cascade, which is crucial for adult memory, in the consol

KPIs as the interface between scheduling and control

The integration of scheduling and control has been discussed in the past. While constructing an integrated plant model that may still seem out of reach, scheduling and control systems are increasingly more intertwined. We argue that they are in fact already integrated and give the example of two key performance indicators (KPIs) that are defined in the recent international standard ISO 22400. The