Objectives: To evaluate the discrimination, calibration, and net benefit performance of the Prostate Cancer Prevention Trial Risk Calculator (PCPTRC) across five European randomized study of screening for prostate cancer (ERSPC), 1 United Kingdom, 1 Austrian, and 3 US biopsy cohorts. Methods: PCPTRC risks were calculated for 25,733 biopsies using prostate-specific antigen (PSA), digital rectal exa

Background: Head computed tomography (CT) is a guideline recommended method to predict functional outcome after cardiac arrest (CA), but standardized criteria for evaluation are lacking. To date, no prospective trial has systematically validated methods for diagnosing hypoxic-ischaemic encephalopathy (HIE) on CT after CA. We present a protocol for validation of pre-specified radiological criteria

In the transition to more sustainable travel behaviour, there is a need to reduce car mileage for all sorts of trips including everyday leisure trips for social and recreational purposes. In this case study, qualitative interviews were conducted to improve and deepen the understanding of transport mode choice for such trips. The analyses of factors affecting mode choice for everyday leisure purpos

Background: Menière’s disease is an idiopathic disorder characterized by recurrent episodes of vertigo lasting more than 20 min, unilateral sensorineural hearing loss, and tinnitus. If vertigo attacks occur frequently, the patient is usually severely incapacitated. Currently, there is no consensus on the treatment of Menière’s disease. The evidence regarding most treatment options is sparse due to

Objective: To determine the relation between concentrations of prostate specific antigen at age 60 and subsequent diagnosis of clinically relevant prostate cancer in an unscreened population to evaluate whether screening for prostate cancer and chemoprevention could be stratified by risk. Design: Case-control study with 1:3 matching nested within a highly representative population based cohort stu

The concept of resource recovery, particularly from waste has recently gained much attention and popularity. The aim of this study was to quantify the potential economic and environmental benefits of recovering nutrients and energy from faecal sludge (FS). The empirical data were collected from three unplanned settlements of Dar es Salaam City at Keko, Kipawa and Manzese. Two scenarios were develo

Objectives. To design protocols for specific and quantitative immunohistochemical detection of human kallikrein 2 (hK2) using lanthanide chelate-labeled monoclonal antibodies (Mabs) and time-resolved fluorescence imaging. Methods. Anti-prostate-specific antigen (PSA) Mabs were tested in microtiterplate assays for their ability to prevent PSA from cross-reacting with the anti-hK2 Mab 6H10. Europium

Today most architecture being built has a lifespan somewhere between 60 to 120 years. In some cases less, in a few cases more. Construction of buildings is a huge consumer of both energy and resources. In the architectural field environmental sustainability are keywords in the design process. Yet, the lifespans of buildings are not being discussed to any great length. The average human life expect

Purpose: Finasteride has been shown to reduce the incidence of prostate cancer. Yet the use of finasteride remains low, likely because of the risk of adverse effects. We sought to determine whether prostate-specific antigen (PSA) levels could identify a high-risk subgroup for which the benefits of finasteride treatment outweigh the potential harms. Patients and Methods: Raw data from the Prostate

Pop is increasingly assimilating the compositional practices of hip- hop and EDM (electronic dance music). This shift is driven by a new generation of Digital Audio Workstations (DAWs). These are less based on a recording studio logic and more a combination of controlling loops and the networked logic of ubiquitous computing (ubicomp) culture. Via new media theory, this article discusses how the p

Syftet med detta projekt har varit att analysera förutsättningarna för cykling i tätorter av olika storlek. En central del i detta arbete var att tillämpa och utvärdera den GIS-baserade GTCmodellen för beräkning av geografisk tillgänglighet för cykling i kommuner och tätorter av olika storlek (Robertson m.fl., 2018). Projektet har genomförts i samarbete med elva kommuner av olika storlek och struk

Surface plasmon resonance, i.e. detection of changes in refractive index on a surface, was used in a biosensor to evaluate the dissociation/association rate and affinity constants of human monoclonal IgG and IgM antibodies and Tab fragments. The results showed that an observed difference in affinity constants between intact and fragmented IgG anti-tetanus antibody was related to approximately 10-f

The nasal route is a convenient and simple way to administer peptides to humans. Absorption of the drug, however, requires passage of the substance through the nasal mucosa. This is a possible site of enzymatic degradation of the peptide. It is shown that rabbit nasal mucosa homogenates rapidly degrade the synthetic anti-diuretic hormone analogue desamino1,D-arginine8-vasopressin in vitro. The met

Prostate-specific antigen (PSA) dynamics have been proposed to predict outcome in men with prostate cancer. We assessed the value of PSA velocity (PSAV) and PSA doubling time (PSADT) for predicting prostate cancer-specific mortality (PCSM) in men with clinically localized prostate cancer undergoing conservative management or early hormonal therapy. From 1990 to 1996, 2,333 patients were identified

Prostate-specific antigen (PSA) has been the main drive for early detection of prostate cancer (PCa), including in population-based screening as in the European Randomised Study for Screening of Prostate Cancer (ERSPC). The specificity of PSA to indicate men with biopsy detectable prostate cancer can be improved by adding information obtained by new biomarkers, such as PSA isoforms. This improveme

BACKGROUND. Protein gene product 9.5 (PGP 9.5) has been considered to be a neuronal marker, but it is also present in extraneuronal tissues, e.g., the human mammary gland and rat epididymis. Its presence and distribution in the developing and adult male human genital tract have been unknown. METHODS. Immunohistochemical reactions were performed on human embryonic and postnatal specimens of the mal

This paper examines how Foreign Direct Investment (FDI) affects Economic Growth and Total Factor Productivity (TFP) for recipient countries in Latin America. The study investigates whether FDI generates positive spillover effects, leading to a higher increase in TFP than domestic investments. According to the Schumpeterian model increasing in TFP would lead to a higher economic growth rate (Lucas,

The genes being studied here are plant Flavin-containing monooxygenase (FMO’s) which are enzymes that place molecular oxygen on heteroatoms such as nitrogen, and sulfur with the help of cofactors such as NAD(P)H and FAD. Plant FMOs are divided into three major clades: N-hydroxylating, S-hydroxylating and YUCCA. The YUCCA family is conserved in all plants, and performs oxidative decarboxylation of