In this study we examined the involvement of the focal adhesion-associated proteins p125FAK and paxillin as substrates for bradykinin (BK)-stimulated tyrosine phosphorylation in Swiss 3T3 cells and the potential role of protein kinase C and Ca2+ in these events. BK (1 UM) stimulated tyrosine phosphorylation of p125FAK and paxillin. In addition, BK also increased the phosphotyrosine content of the

Bradykinin exhibits proliferative influences in several types of cells; however, in the present study, bradykinin did not promote DNA synthesis but actually inhibited the DNA synthesis induced by epidermal growth factor (EGF) and platelet-derived growth factor (PDGF) in human gingival fibroblasts (HGF). This dose-dependent inhibitory effect was a specific intracellular interaction in that increas

γ-Aminobutyric acid (GABA) increases the rate of 36Cl- efflux from preloaded rat hippocampal slices in a dose-dependent manner (EC50: 400 μM). This action has the pharmacological specificity expected of activation of GABA receptor in that it is mimicked by the agonists muscimol and 3-aminopropanesulfonic acid, and blocked by the antagonists bicuculline and picrotoxinin. GABA uptake inhibitors, nip

Unlike the anesthetic barbiturate pentobarbital and the anxiolytic pyrazolopyridine etazolate, which enhance [3H]diazepam binding to rat brain membranes, the anticonvulsant barbiturates phenobarbital and metharbital, and also chlormethiazole, at therapeutic concentrations (10-1000 μM), do not stimulate [3H]diazepam binding, but instead block the enhancement by both pentobarbital and etazolate. The

Ground removal during the mineral extraction in mine galleries provokes permanent changes in ground compacting during mine exploitation and after mine closure. In extreme cases, the loss of cohesion in ground layer over mines causes surface subsidence and eventually the emergence of flooded areas on the surface. Mining companies are obligated to the surveillance and mending of damages caused by th

The compound Y 3 R u2−x was synthesized from the elements and the structure was solved from single crystal synchrotron data. The high quality of the data allowed the determination of the incommensurate ordering of the compound, previously reported as disordered, with respect to the second subsystem. The compound crystallizes in the super space group X-3(00γ)0 with the q-vector axial along c*, q

The new version of the MadGraph/MadEvent (MG/ME) MC generator is introduced by emphasizing its easy-to-use way of incorporating new models and generating events. As an application, a study of t t production in various scenarios beyond the standard model is presented.

We present the predictions at next-to-leading order (NLO) in the strong coupling for the single-top cross section in the t channel at the Tevatron and the LHC. Our calculation starts from the 2→3 Born amplitude gq→tb̄q′, keeping the b-quark mass nonzero. A comparison is performed with a traditional NLO calculation of this channel based on the 2→2 Born process with a bottom quark in the initial sta

In this talk we give an overview of the existing codes that aim for the automation of the subtraction terms in next-to-leading order calculations in perturbative QCD.

Heading towards a full automation of next-to-leading order (NLO) QCD corrections, one important ingredient is the analytical integration over the one-particle phase space of the unresolved particle that is necessary when adding the subtraction terms to the virtual corrections. We present the implementation of these integrated dipoles in the MadGraph framework. The result is a package that allows a

AbstractPURPOSE: To determine whether the presence of one or more cilioretinal arteries, a distinct element of the pattern of fundus vessels, is genetically programmed, influenced by environmental factors, or the result of random mechanisms of vascular development. METHODS: The fundi of 112 pairs of healthy monozygotic and dizygotic twins were examined using digital fundus photography and visual a

Particle-assisted III-V semiconductor nanowire growth and applications thereof have been studied extensively. However, the stability of nanowires in contact with the particle and the particle chemical composition as a function of temperature remain largely unknown. In this work, we use in situ transmission electron microscopy to investigate the interface between a Au-Ga particle and the top facet

N-methyl-D-aspartate-receptors are implicated in several neuropathological conditions including epilepsy. As a model of complex partial seizures, rapid hippocampal kindling was chosen to investigate changes in the expression of messenger RNAs encoding the N-methyl-D-aspartate-receptor subunits NR1, NR2A and NR2B both during and in the period immediately following the induction of the kindled state

For s∈ ℝ the weighted Besov space on the unit ball Bd of ℂd is defined by (Formula presented.). Here Rs is a power of the radial derivative operator (Formula presented.), V denotes Lebesgue measure, and ω is a radial weight function not supported on any ball of radius < 1. Our results imply that for all such weights ω and ν, every bounded column multiplication operator (Formula presented.) induces

This study presents a comprehensive analysis of farmers' income in Sweden. The results indicate that farm households in Sweden do well from a standard-of-living perspective, but that farming is still a low-paid occupation from a return-on-skills perspective. Nevertheless, farm earnings increased faster over the study period than earnings in the general population, owing equally to higher farm earn

Background: Perioperative fluid overload has been reported to increase complications after a variety of operative procedures. This study was conducted to investigate the incidence of fluid retention after pancreatic resection and its association with postoperative complications. Methods: Data from 1174 patients undergoing pancreatoduodenectomy between 2010 and 2016 were collected from the Swedish