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Cerebral ischemia that develops after subarachnoid hemorrhage (SAH) carries high morbidity and mortality. Inflammatory mediators are involved in the development of cerebral ischemia through activation of the mitogen-activated protein kinase pathway. We hypothesized that blockade of the MAPkinase/ERK (MEK)/extracellular signal-regulated kinase (ERK) pathway upstream with a specific raf inhibitor wo

Parnetti L, Chiasserini D, Andreasson U, Ohlson M, Hüls C, Zetterberg H, Minthon L, Wallin ÅK, Andreasen N, Talesa VN, Blennow K. Changes in CSF acetyl- and butyrylcholinesterase activity after long-term treatment with AChE inhibitors in Alzheimer's disease.Acta Neurol Scand: DOI: 10.1111/j.1600-0404.2010.01435.x. © 2010 John Wiley & Sons A/S. Objectives - To measure cerebrospinal fluid (CSF)

Until 4 decades ago, the rates of stroke in low- and middle-income countries were considerably lower than those in more economically robust countries. In the intervening years, however, the rates of stroke in places such as southern India and rural South Africa have approximately doubled, whereas stroke rates in more economically developed nations have decreased. What is far more striking is that

BACKGROUND: Cyclin A1 is a cell cycle regulator that has been implicated in the progression of prostate cancer. Its role in invasion and metastasis of this disease has not been characterized. METHODS: Immunohistochemistry and cDNA microarray analyses were used to assess protein and mRNA expression of cyclin A1 and proteins with roles in metastasis, including vascular endothelial growth factor (VEG

The faculty opposition of Stig Lundbergs licentiate thesis concerning the so-called Eskilstuna sarcophagi. The long dating-sequence of the stones and their unclear social origin aggravate their use in describing the state formation process. The author proposes a little dirrefent interpretaion than Lundberg.

The paper introduces a peer-to-peer system called P2PRIV (peer-to-peer direct and anonymous distribution overlay). Basic novel features of P2PRIV are: (i) a peer-to-peer parallel content exchange architecture, and (ii) separation of the anonymization process from the transport function. These features allow a considerable saving of service time while preserving high degree of anonymity. In the pap

Apolipoprotein M (apoM) is predominantly associated with HDL. In this study, it was investigated whether apoM's uncleaved signal peptide is necessary for the protein's ability to associate with lipoproteins. ApoM with a cleavable signal peptide, Q22A, was expressed, together with wild-type apoM, in HEK293 cells. On size-exclusion chromatography, the elution profile of wild-type apoM was similar to

The Lake Poopo basin, located on the Bolivian Altiplano, is extremely vulnerable to environmental degradation. The basin displays extreme spatial and temporal variations of water resources and rapidly decreasing water quality due to anthropogenic and natural pollution. The region’s population lives in extreme poverty, and the authorities’ efforts to manage the water resources efficiently have been

Pragma-dialectical argumentation theory has received criticism from epistemological argumentation theorists. While the former emphasizes argumentation as aimed at resolving differences of opinion through adequate procedures, the latter emphasizes that argumentation is aimed at reaching a justified conclusion of the argumentation. In this paper pragma-dialectics is analyzed and two objections consi

In this paper, we propose a preemptive test scheduling technique (a test can be interrupted and later resumed) for core-based systems with the objective to minimize the test application time. We make use of reconfigurable core test wrappers in order to increase the flexibility in the scheduling process. The advantage with such a wrapper is that it is not limited to a single TAM (test access mechan

OBJECTIVES: Acute superior mesenteric artery (SMA) occlusion can be diagnosed in an early phase by computed tomography (CT) angiography, which is also a prerequisite for endovascular intervention. However, the issue of development of postoperative permanent renal failure due to contrast-induced nephropathy has not been evaluated. DESIGN: Retrospective MATERIALS: A total of 55 patients with acute S

This article aims to contribute to the understanding concerning the introduction of crisis psychotherapy in the 1970s in psychiatric clinics in Sweden. The article discusses how this psychotherapy became central in the work of the clinics in supporting patients to well-being and inner growth. The ambition was that patients in an acute crisis-situation would be offered care immediately, aiming at a