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Breathlessness that persists despite treatment for the underlying conditions is debilitating. Identifying this discrete entity as a clinical syndrome should raise awareness amongst patients, clinicians, service providers, researchers and research funders.Using the Delphi method, questions and statements were generated via expert group consultations and one-to-one interviews (n=17). These were subs
Sponge city construction can improve cities’ ability to adapt to the environment change and the ability to cope with floods, and it can also prompt cities’ development to be more healthy and sustainable. However, the process itself of sponge city construction may also has impact on the environment especially in built-up areas, to reduce the impact, the rainwater landscape design needs to integrate
Amyloid plaques and neurofibrillary tangles (NFTs) in the brain are the neuropathological hallmarks of Alzheimer's disease (AD). Amyloid plaques are composed of β-amyloid peptides (Aβ), while NFTs contain hyperphosphorylated tau proteins. Patients with familial AD who have mutations in the amyloid precursor protein (APP) gene have either increased production of Aβ or generate more aggregation-pron
In this tutorial paper we first present some foundational results regarding the theory of positive systems. In particular, we present fundamental results regarding stability, positive realization and positive stabilization by means of state feedback. Special attention is also paid to the system performance in terms of disturbance attenuation. Under the asymptotic stability assumption, such perform
A performance-based approach is developed for adaptive robust control of linear systems with uncertain parameters. The dual control objective involves the disturbance attenuation and worst case identification of the unknown parameters. The proposed synthesis procedure relies on sufficient conditions, given in terms of suitable solutions of perturbed differential Riccati equations to exist. Althoug
Changes in the inlet morphology of choked coastal lagoons often restrict the water exchange with the sea, making them vulnerable to pollution release and eutrophication processes. In this study, the role of tides for the water exchange was investigated in a choked lagoon for critical scenarios during the low river flow season. Both an integrated and spatially distributed approach were employed usi
This article discussed the history of the position of the married woman in Dutch personal income tax law in its historical, juridical en social-cultural background. From 1892-1984 married women were in fact tax transparent in the Netherlands
A recent naturalistic epistemological account suggests that there are three nested basic forms of knowledge: procedural knowledge-how, conceptual knowledge-what, and propositional knowledge-that. These three knowledge-forms are grounded in cognitive neuroscience and are mapped to procedural, semantic, and episodic long-term memory respectively. This article investigates and integrates the neurosci
This paper argues that although solidarity was developed as a principle in EU law to enhance the unity and cooperation between the Member States, its viability at the transnational level remains ultimately a function of its efficacy at the micro level of EU citizens. The question at the core of this inquiry concerns, therefore, how micro and macro dimensions of solidarity are related to each otherThis paper argues that although solidarity was developed as a principle in EU law to enhance the unity and cooperation between the Member States, its viability at the transnational level remains ultimately a function of its efficacy at the micro level of EU citizens. The question at the core of this inquiry concerns, therefore, how micro and macro dimensions of solidarity are related to each other
In the Sustainable Development Goals era, there is a new awareness of the need for an integrated approach to healthcare interventions and a strong commitment to Universal Health Coverage. To achieve the goal of strengthening entire health systems, surgery, as a crosscutting treatment modality, is indispensable. For any health system strengthening exercise, baseline data and longitudinal monitoring
OBJECTIVE: To assess the value of arterial duplex ultrasound, which assesses the location and severity of arterial disease, in determining whether invasive vascular intervention is required.METHOD: A total of 166 consecutive diabetic patients presenting at a multidisciplinary foot clinic with severe peripheral vascular disease, with or without a foot ulcer, were included in this prospective study.
DN DEBATT 2/2. Även om regleringen av läkemedel i Sverige är effektiv, tyder mycket på att förekomsten av förfalskade läkemedel tilltar. Ett nytt EU-direktiv som träder i kraft nästa vecka ska förhindra spridning av förfalskade läkemedel. Det skapar förutsättningar för att spåra och stoppa farliga produkter, skriver forskaren Susanne Lundin.
The effects of extracellular calcium and magnesium on bile-salt-induced amylase release from rat pancreatic acini have been studied. The amylase releases caused by from 0.25 mM to 1.0 mM taurodeoxycholate (TDC) and by taurochenodeoxycholate (TCDC) at a concentration of more than 0.75 mM were reduced by ethylenediaminetetraacetic acid (EDTA) and increased by verapamil. EDTA and verapamil had no sig
Rat pancreatic juice was collected from female, anesthetized Sprague-Dawley rats (200–250 g) during basal secretion and after 45-min intravenous infusion for secretin or secretin with cholecystokinin (CCK). The volume of secretion was measured as well as activity of lipase and colipase. It was shown that the basal secretion of pancreatic juice gave a colipase/lipase (C/L) ratio of about 0.5. Stimu
The effects of verapamil on amylase release and Ca2+ fluxes from rat pancreatic acini have been studied. Verapamil at concentrations above 10 FM dose-dependently inhibited amylase release stimulated by carbachol, but enhanced the amylase release stimulated by cholecystokinin (CCK) and secretin. Verapamil had no significant effect on calcium uptake induced by carbachol or CCK, but significantly inh
