Data-driven studies on the dynamics of reconstructed protein-protein interaction (PPI) networks facilitate investigation and identification of proteins important for particular processes or diseases and reduces time and costs of experimental verification. Modeling the dynamics of very large PPI networks is computationally costly.

Background Leaf-cutting ants live in symbiosis with a fungus that they rear for food by providing it with live plant material. Until recently the fungus' main inferred function was to make otherwise inaccessible cell wall degradation products available to the ants, but new studies have shed doubt on this idea. To provide evidence for the cell wall degrading capacity of the attine ant symbiont, we

Glutamic acid decarboxylase 65 (GAD65) and autoantibodies specific for GAD65 (GADA) are associated with autoimmune diseases including Stiff Person Syndrome (SPS) and Type 1 diabetes (T1D). GADA is recognized as a biomarker of value for clinical diagnosis and prognostication in these diseases. Nonetheless, it remains medically interesting to develop sensitive and specific assays to detect GAD65 pre

This thesis is mainly concerned with the intersection between ideals and (maximal commutative) subrings of graded rings. The motivation for this investigation originates in the theory of C*-crossed product algebras associated to topological dynamical systems, where connections between intersection properties of ideals and maximal commutativity of certain subalgebras are well-known. In the last few

Background and purpose - The pathophysiology behind bis-phosphonate-associated atypical femoral fractures remains unclear. Histological findings at the fracture site itself may provide clues. Patients and methods - Between 2008 and 2013, we collected bone biopsies including the fracture line from 4 complete and 4 incomplete atypical femoral fractures. 7 female patients reported continuous bisphosp

Importance Active perinatal care increases survival of extremely preterm infants; however, improved survival might be associated with increased disability among survivors. Objective To determine neurodevelopmental outcome in extremely preterm children at 2.5 years (corrected age). Design, Setting, and Participants Population-based prospective cohort of consecutive extremely preterm infants born be

Insights into how exactly a fly powers and controls flight have been hindered by the need to unpick the dynamic complexity of the muscles involved. The wingbeats of insects are driven by two antagonistic groups of power muscles and the force is funneled to the wing via a very complex hinge mechanism. The hinge consists of several hardened and articulated cuticle elements called sclerites. This art

Objectives. To investigate survival, treatment escalation, effects of first-line single- and first-line combination therapy and prognostic markers in idiopathic- (IPAH), hereditary- (HPAH) and connective tissue disease-associated (CTD-PAH) pulmonary arterial hypertension (PAH). Design. Retrospective analysis of medical journals from PAH patients at Skane University Hospital 2000-2011. Results. 1-,

Efforts by the European Commission and by leading member states, to normatively frame the debate about trade - and thus rhetorically entrap other actors by references to previous commitments - are ubiquitous; and member states do take account of the potential effects of their actions, in terms of potential praise or shaming, and adapt their behaviour to the institutional setting. However, this hol

Gas in scattering media absorption spectroscopy (GASMAS) has been extensively studied and applied during recent years in, e.g., food packaging, human sinus monitoring, gas diffusion studies, and pharmaceutical tablet characterization. The focus has been on the evaluation of the gas absorption pathlength in porous media, which a priori is unknown due to heavy light scattering. In this paper, three

Dissolution rate measurements are important to understand the behaviour of drugs or drug formulations. Many methods for measuring dissolution rates are available and a good choice should be based on method limitations as well as drug characteristics. In the present study the rotating disc method was critically evaluated for dissolution rate measurements, using aspirin and benzoic acid as model sub

Retinopathy of prematurity (ROP) is a sight-threatening disease, requiring efficient screening and treatment. The present study aims to describe various aspects on treatment for ROP in Sweden.

The cover of the latest volume of the scientific flora Flora Nordica (2010) is illustrated with a picture of the mezereon plant, Daphne mezereum, taken from J. W. Palmstruch’s old Swedish flora Svensk botanik (1802). In his preface, Palmstruch states that the illustrations are most often depicted from nature, but ”sometimes borrowed, with or without improvements” from four quoted international wor

New types of knowledge, and new ways of organising the production of it, may emerge as knowledge producers respond to the challenges posed by a changing society. This paper focuses on the core knowledge of one such emerging field, namely, innovation studies. To explore the knowledge base of the field, a database of references in scholarly surveys of various aspects of innovation, published in "han